A study of potential drug-drug interactions among critically ill patients at a tertiary care hospital

Gupta, Manjeeta; Chincholkar, Aparna S.; Wagh, Ranjit J.; Maheshwari, Nidhi; Siddiqui, Waseem

doi:10.18203/2319-2003.ijbcp20161899

Cited by 6 publications

(18 citation statements)

References 12 publications

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“…Our study showed a high prevalence of pDDI (81.2%) along with the presence of polypharmacy and the majority of pDDI were clinically relevant (75.08%) which was almost similar to the studies done by Hamidy et al 14 Valizade et al 15 Gupta et al 16 in critically ill patients stressing to the need for increased awareness about the pDDI in health care providers. The reason may be due to the increased number of drugs prescribed per patients with the average number being 7.95±3.07.…”

Section: Discussionsupporting

confidence: 89%

Prevalence of Potential Drug-Drug Interactions in the Intensive Care Unit of a Tertiary Care Hospital: A Cross-Sectional Study

Acharya¹,

Ragam²,

Holla³

et al. 2019

JYP

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Objective: To analyze the various Potential Drug-Drug Interactions in ICU patients with the ultimate goal of raising awareness among clinicians on safe medication usage. Materials and Methods: This was a Cross-sectional study conducted at a tertiary care hospital. The medical records of the patients admitted to the ICU of the hospital from January 2017 to June 2017 formed material for the study, were analyzed using the database from Lexicomp ® Solutions android mobile application for Potential Drug-Drug Interactions. Results: Among the 176 patients,81.39% had Potential Drug-Drug Interactions, with cardiovascular drugs (22.6%) being the majority group followed by respiratory drugs (17. 97%). Among these 73.2% of the interactions were clinically relevant with the majority being moderate (72.26%) in severity with fair (72.6%) documentation and belonging to Category C (61.080%) in risk rating. The pharmacodynamics type of interactions was more (59.31%) than pharmacokinetic type (36.13%). Conclusion: The high prevalence of Potential Drug-Drug in the ICU setting emphasizes the need for effective medication management and pharmacological consultation to reduce the adverse effect and improve the therapeutic outcome in these patients.This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Section: Discussionsupporting

confidence: 89%

Prevalence of Potential Drug-Drug Interactions in the Intensive Care Unit of a Tertiary Care Hospital: A Cross-Sectional Study

Acharya¹,

Ragam²,

Holla³

et al. 2019

JYP

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“…4 Our study had male preponderance (60%) which was similar to a study conducted by Manjeeta Gupta et al (67.2%). 13 Majority of the drugs were administered by parenteral route (61.5%) which is similar to a study conducted by Lima et al (62.3%).…”

Section: Discussionsupporting

confidence: 83%

“…A study by Manjeeta Gupta et al reported a similar result, about 60.26% of pDDI belonged to category C while 14.41% and 3.93% belonged to category D and X respectively. 13 Our study showed that occurrence of pDDI was directly proportional to the number of drugs administered. This is in accordance with the study conducted by Reis et al which concluded that there is association between pDDI and the number of drugs used.…”

Section: Discussionmentioning

confidence: 62%

“…4 A study by Manjeeta Gupta et al showed a similar result, about 60% of the observed pDDI were of moderate in nature. 13 According to the Lexicomp drug interact risk scale of pDDI, in this study, category C was the most common 67% which required monitoring of therapy, followed by Category B (17%), D (14%) and X (2%). A study by Manjeeta Gupta et al reported a similar result, about 60.26% of pDDI belonged to category C while 14.41% and 3.93% belonged to category D and X respectively.…”

Section: Discussionmentioning

confidence: 64%

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A prospective observational study to evaluate potential drug-drug interactions in patients admitted in intensive care unit, at BRIMS tertiary care hospital in Bidar, India

Singh

Swetha

2018

Int J Basic Clin Pharmacol

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Background: Drug interaction occurs when presence of one drug affects the activity of another when, both are co-administered. 6-30% of adverse events (AEs) with significant hospitalizations or death are by drug-drug interactions(DDI). There is increased possibility to prevent the potential drug-drug interactions (pDDIs), if their prevalence and pattern are determined accurately before their occurrence. Hence this study aimed to evaluate the prevalence of pDDIs in ICU patients at BRIMS tertiary care hospital, Bidar.Methods: This prospective observational study included 30 patients admitted in ICU of BRIMS hospital for >24hrs of either gender, aged >18yrs. The study was conducted for a period of 3 months. Data was collected from the case records of patients on the predesigned proforma. Potential drug-drug interactions were classified based on their severity and the risk of Potential drug-drug interactions was estimated by Lexicomp, inc.version; 3.0.1.drug interact android mobile application.Results: Out of 35 patients admitted in the ICU, 30 cases were included in the study. The mean age of study population was 56.3years. The study population was exposed to a total of 330 medicines during the hospital stay with an average of 11.7 drugs per patient. The prevalence of pDDI was 93.3% (28) with an average of 9.75 pDDI per patient. According to Lexicomp drug interact android mobile application majority (63%) of pDDI were found to be moderate in their severity, 67% belonged to type C risk.Conclusions: The study showed higher prevalence of pDDI among ICU patients due to the complexity of the pharmacotherapies administered.

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“…2 The abovementioned risk factors are associated with patients in ICU settings thus they are at greater risk for experiencing pDDIs. 3 A study done in ICU showed that risk of a pDDI increases by approximately 6% per day. 3 Often pDDIs go unnoticed in these patients as their symptoms due to disease mask the symptoms caused by pDDIs.…”

Section: Introductionmentioning

confidence: 99%

Identification and Assessment of Potential Drug–Drug Interactions in Intensive Care Unit Patients

Wagh

Godbole

Deshmukh

et al. 2019

Indian Journal of Critical Care Medicine

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Context Intensive care unit (ICU) patients suffer from various comorbidities and usually receive complex pharmacotherapy which increases the risk of drug-drug interactions (DDIs). Aim To identify and assess potential DDIs (pDDIs) in ICU patients. Settings and design A prospective observational study conducted in ICU of a tertiary care hospital for a period of 6 months. Materials and methods Patient information was noted in the data collection form and pDDIs were assessed using Micromedex®database. Statistical analysis used Chi-square test was used to find correlation of pDDIs with patient parameters. p value was calculated keeping the significance level 0.05. Results Total 400 subjects were included; having an average age of 55.99 ± 15.62 years with a higher percentage of males (61.75%). About 305 (76.25%) patients were found with pDDIs, showing an average of 2.93 pDDIs/patient. The findings of this study were as follows: Total interactions = 1171, contraindicated = 6 (1%), major = 715 (61%), moderate = 428 (36%), and minor = 22 (2%) pDDIs. Further, majority of pDDIs had onset of action “not specified” documentation “fair” and probable mechanism “pharmacodynamic” in nature. Significant association of occurrence of pDDIs was found with number of drugs prescribed to patients in ICU. Conclusion This study demonstrated a high prevalence of pDDI in ICU due to the complexity of pharmacotherapy which showed major pDDIs as the most evident (61%) while contraindicated were 1%. Further studies are needed to better explore this area which may help in realizing the goal of good clinical practice and may offer a methodology to further increase drug safety. Key messages “Monitoring and assessment of DDIs is needed for better patient care”. How to cite this article Wagh BR, Godbole DD, et al. Identification and Assessment of Potential Drug-Drug Interactions in Intensive Care Unit Patients. Indian J Crit Care Med 2019;23(4):170-174.

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A study of potential drug-drug interactions among critically ill patients at a tertiary care hospital

Cited by 6 publications

References 12 publications

Prevalence of Potential Drug-Drug Interactions in the Intensive Care Unit of a Tertiary Care Hospital: A Cross-Sectional Study

Prevalence of Potential Drug-Drug Interactions in the Intensive Care Unit of a Tertiary Care Hospital: A Cross-Sectional Study

A prospective observational study to evaluate potential drug-drug interactions in patients admitted in intensive care unit, at BRIMS tertiary care hospital in Bidar, India

Identification and Assessment of Potential Drug–Drug Interactions in Intensive Care Unit Patients

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