“A Study of Position Related Changes in Uroflowmetric Parameters Before & After Treatment in Patients with Benign Prostatic Hyperplasia and Study of Revised Modified Luts Questionnaire in These Patients”

Abstract

Objective: The aim of this study was to compare the uroflowmetric parameters in 3 different voiding positions before initial treatment for LUTS, compare position specific uroflowmetric parameters before & after treatment & to compare IPSS/AUA symptom index with study questionnaire(PGIMER questionnaire) before & after treatment for LUTS. Material & methods: In total , 91 patients with symptomatic BPH were enrolled in this prospective controlled trial. The IPSS/AUA score was > 7/35 & QOL was >2/6. Patients were divided into 2 groups i.e. one who did not receive any medical treatment for BPH & others who were treated with alpha blockers. But the drug was discontinued for atleast 15d before taking baseline measurements. The participants were asked to fill the IPSS/AUA questionnaire & study questionnaire(which we have named as PGIMER Questionnaire) on 2 occasions i.e. before starting treatment & 6W after treatment. Uroflowmetry & post void residual urine was checked in all 3 positions i.e. standing, sitting & squatting position both before & 6W after treatment. Results: In total, 91 patients were studied. There was no significant difference(p>0.005) in uroflowmetric parameters in various voiding positions both before & after treatment. Before treatment, strong correlation was found between IPSS voiding with PGIMER questionnaire voiding & moderate correlation between IPSS storage & PGIMER questionnaire storage symptom score. QOL in IPSS was moderately correlated with PGIMER questionnaire. After treatment, IPSS voiding score was strongly correlated with PGIMER voiding score & weakly correlation of IPSS storage & PGIMER questionnaire storage was found. QOL in IPSS was weakly correlated with PGIMER questionnaire. Conclusion: There was no significant difference in uroflowmetric parameters in different voiding positions. Alpha blockers significantly improved the patient's symptom score & global QOL index. The PGIMER questionnaire showed significant correlation with IPSS questionnaire.