A Study of Plasma Apolipoprotein A-1 and Apolipoprotein B Levels in Patients with Coronary Artery Disease

Background Lipoprotein a Lp a contains apolipoprotein a , a structural homologue of plasminogen that competes with it for binding sites. It also acts by increasing plasminogen activator inhibitor-1 expression. The objective of this study was to evaluate the relationship between Lp a levels and the restenosis rate following successful coronary stent placement. Methods The study included 306 patients who underwent coronary stent placement and follow-up coronary angiogram at Chonnam National University Hospital from August 1996 to June 2000. The restenosis rate was analyzed according to the level of Lp a Group I with high Lp a n 77, Lp a 36 mg/dL, 58.9 8.8 years, female 35.1% and Group II with low Lp a n 229, Lp a 36 mg/dL, 57.7 9.8 years, female 18.8% . Results 1 There were no significant differences in the risk factors of atherosclerosis, clinical diagnosis, the number of involved coronary arteries, left ventricular function, and angiographic lesion characteristics by American College of Cardiology/American Heart Association classification or Thrombolysis In Myocardial Infarction flow in the two groups. 2 The angiographic restenosis rates did not differ between the two groups group I 33.8%, group II 35.4% . Conclusion Plasma Lp a levels are not related with the angiographic restenosis rate following coronary stent placement. Korean Circulation J 2001 ; 30 5 : 476-483 KEY WORDS Coronary·Artery·Stents·Restenosis·Lipoprotein a . 서 론 477 대상 및 방법 대 상 방 법

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The Effects of Lipoprotein(a) on Coronary Stent Restenosis

Rhew

Jeong

Hong

et al. 2001

Korean Circ J

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Concordance/Discordance between Apolipoprotein B Levels and the Cholesterol Indexes

Hwang

Kim

et al. 2005

Korean Circ J

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Background and Objectives：Apolipoprotein B (Apo-B) has been reported to be a better predictor of the coronary artery disease (CAD) than the cholesterol indexes. The aim of this study was to examine the concordance/discordance between the apolipoprotein B levels and the cholesterol indexes, and to assess the factors affecting the discordance. Subjects and Methods：A total of 11,816 participants (6,965 men and 4,851 women) were enrolled in this study from all the individuals who participated in medical screening examinations at the health promotion center in Kangbuk Samsung Hospital from January to December 2002. All the participants had no history of coronary artery disease. We assessed the concordance between the biochemical parameters of the atherogenic indexes, and we evaluated the factors affecting the discordance. Results：Despite the fact that the Apo-B and the various cholesterol indexes were highly correlated, the concordance rate was merely 47-56%. Multinomial logistic regression analysis showed the possibility of an increased risk for the group of discordance in whom Apo-B level was disproportionately higher than LDL cholesterol in the elderly, the smokers, the men and the people having a larger waist circumference, a lower total cholesterol level, a higher triglyceride level and a higher HDL-C level. Conclusion：The measurement of apo B, along with the measurement of the standard lipid profile, could be a great help in evaluating the CAD risk and for aiding in the treatment of dyslipidemia in the elderly, the smokers, men and the people having a larger waist circumference, a lower total cholesterol level, a higher triglyceride level and a higher HDL-C level.

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A Study of Plasma Apolipoprotein A-1 and Apolipoprotein B Levels in Patients with Coronary Artery Disease

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The Effects of Lipoprotein(a) on Coronary Stent Restenosis

The Effects of Lipoprotein(a) on Coronary Stent Restenosis

Concordance/Discordance between Apolipoprotein B Levels and the Cholesterol Indexes

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