A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with Raltitrexed

Qiu, Cen; Li, Yueqi; Liang, Xin; Qi, Yiwen; Chen, Yiyang; Meng, Xiangjun; Zheng, Hua; Xu, Ye; Cai, Sanjun; Cai, Guoxiang; Liu, Jianwen

doi:10.1016/j.biopha.2017.04.053

Cited by 10 publications

(25 citation statements)

References 27 publications

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“…In this study, the effect of RTX was potentiated by hyperthermia, suggesting that hyperthermia combined with agents has the potential to control invasive carcinomatosis. With 42°C, RTX treatment further suppressed migration compared with 37°C, which was consistent with the previous report, partly due to the fact that hyperthermic perfusion facilitated the intracellular absorption of RTX and increased ROS generation.…”

Section: Discussionsupporting

confidence: 92%

“…The control groups received equal volumes of 0.9% saline solution. The perfusion with HIPEC was performed as previously reported . In short, the closed‐circuit fluid circulation was brought into effect with two perfusion catheters in the abdominal cavity of the mice.…”

Section: Methodsmentioning

confidence: 99%

“…The mice were then given intraperitoneal injection of saline (10 mL kg −1 ), or RTX (2 mg m −2 , 4 mg m −2 ), or HIPEC treatment. 27 Then, tumor progression continued to be monitored by an in vivo fluorescence imaging system weekly. After another 3 weeks, the mice were killed.…”

Section: Hipec Further Suppresses Tumormentioning

confidence: 99%

“…We previously discovered that HIPEC therapy further provoked apoptosis in nude mice with PC by promoting intracellular absorption of agents. 27 Intracellular ROS may be another key event in mediating cell cycle arrest and apoptosis. In this study, we measured the ROS generation to discover whether hyperthermia increased the efficacy by inducing oxidative stress effect.…”

Section: Hyperthermia Induced Production Of Ros In Hct116 Cellsmentioning

confidence: 99%

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17‐allylamino‐17‐demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species‐induced cell death

Chen

Qiu

et al. 2018

J of Cellular Biochemistry

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Hyperthermia enhances the anticancer effects of thymidylate synthase (TYMS) inhibitors (raltitrexed, RTX) and improves the precise biochemical mechanisms partially through enhancement of intracellular drug absorption. Recent research focuses on the potential anticancer drug target Heat Shock Protein 90 (HSP90), which could increase the sensitivity of cancer cells to TYMS inhibitors; however, with different HSP90 inhibitors, several research studies finally showed a poor efficacy in preclinical or clinical research. Here, we showed that 17‐allylamino‐17‐demethoxygeldanamycin (17‐AAG, HSP90 inhibitor) affects the efficacy of chemotherapy through antioxidant activation–induced resistance. In this study, we found that RTX, alone or in combination with hyperthermia, triggers reactive oxygen species (ROS) exposure and thus induces cell death. Also, the addition of hyperthermia showed more ROS exposure and function. The pharmacologic inhibition of HSP90 reversed the effects of chemotherapeutical treatments, while the overexpression of HSP90 showed no relation with these effects, which demonstrated that dysregulation of HSP90 might have a significant impact on chemotherapeutic treatments. The addition of 17‐AAG increased the activation of antioxidant with increased antioxidant enzymes, thus affecting the RTX efficacy.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Hipec Further Suppresses Tumormentioning

confidence: 99%

Section: Hyperthermia Induced Production Of Ros In Hct116 Cellsmentioning

confidence: 99%

See 2 more Smart Citations

17‐allylamino‐17‐demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species‐induced cell death

Chen

Qiu

et al. 2018

J of Cellular Biochemistry

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“…However, its biological behavior does not mimic/replicate the human CRC and other solid tumors, leaving the peritoneum models a tool for evaluating nonsolid tumors like leukemia's and to assess pharmacologic responses, since peritoneal metastatic carcinoma has worse prognosis compared with other metastasis and the treatments available did not achieve/have not achieved a good rate of effectiveness yet …”

Section: What Type Of Crc Models Exist?mentioning

confidence: 99%

The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Oliveira

Abrantes

Tralhão

et al. 2020

Anim Models and Exp Med

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Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models. K E Y W O R D Scolorectal cancer, mouse model, orthotopic model

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Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells

Su,

Chen,

Yang

et al. 2024

International Journal of Hyperthermia

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A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with Raltitrexed

Cited by 10 publications

References 27 publications

17‐allylamino‐17‐demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species‐induced cell death

17‐allylamino‐17‐demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species‐induced cell death

The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells

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