A study of P300 in melancholic depression—Correlation with psychotic features

Santosh, Paramala; Malhotra, Savita; Raghunathan, Murugeshachetty; Mehra, Y. N.

doi:10.1016/0006-3223(94)90046-9

Cited by 51 publications

(29 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have shown a reduction in amplitude (Gangadhar et al 1993;Roschke and Wagner 2003), but others have failed to find a reduced P3b amplitude (Hansenne et al 1994). P300 amplitude was reduced in bipolar psychotic disorder (Muir et al 1991), and in depressed patients (Bange and Bathien 1998;Salisbury et al 1998Salisbury et al , 1999Santosh et al 1994).…”

Section: Introductionmentioning

confidence: 93%

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Sokhadze

Tasman

Tamas

et al. 2010

Appl Psychophysiol Biofeedback

View full text Add to dashboard Cite

There appears to be a significant disconnect between symptomatic and functional recovery in bipolar disorder (BD). Some evidence points to interepisode cognitive dysfunction. We tested the hypothesis that some of this dysfunction was related to emotional reactivity in euthymic bipolar subjects may effect cognitive processing. A modification of emotional gender categorization oddball task was used. The target was gender (probability 25%) of faces with negative, positive, and neutral emotional expression. The experiment had 720 trials (3 blocks × 240 trials each). Each stimulus was presented for 150 ms, and the EEG/ERP responses were recorded for 1,000 ms. The inter-trial interval was varied in 1,100-1,500 ms range to avoid expectancy effects. Task took about 35 min to complete. There were 9 BD and 9 control subjects matched for age and gender. Reaction time (RT) was globally slower in BD subjects. The centro-parietal amplitudes at N170 and N200, and P200 and P300 were generally smaller in the BD group compared to controls. Latency was shorter to neutral and negative targets in BD. Frontal P200 amplitude was higher to emotional negative facial non-targets in BD subjects. The frontal N200 in response to positive facial emotion was less negative in BD subjects. The frontal P300 of BD subjects was lower to emotionally neutral targets. ERP responses to facial emotion in BD subjects varied significantly from normal controls. These variations are consistent with the common depressive symptomology seen in long term studies of bipolar subjects.

show abstract

Section: Introductionmentioning

confidence: 93%

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Sokhadze

Tasman

Tamas

et al. 2010

Appl Psychophysiol Biofeedback

View full text Add to dashboard Cite

show abstract

“…All together, the reductionist approach of a positive/negative dichotomy has led to some heterogeneous conclusions. Results of a more syndromal approach were findings of a smaller P300 in melancholic patients with psychotic features, i.e., hallucinations and/ or delusions [42] . A recent study [43] found that patients with a delusional misidentification syndrome showed less excessive reduction of left prefrontal P300 amplitude but prolonged latency in the central midline region as opposed to schizophrenics without delusional misidentification syndrome.…”

Section: Findings Of Imaging and Neurophysiological Studiesmentioning

confidence: 99%

Theories of Delusional Disorders

2007

View full text Add to dashboard Cite

Delusional syndromes can occur in a number of psychiatric, neurological or other disorders. They can also be caused by neurotoxic agents (e.g., heavy metals) as well as substance addiction. There are several hypotheses on the underlying cognitive or emotional processes associated with organic factors of delusional disorders, depending on the patient groups examined and the methods used. The aim of this paper is to provide a comprehensive review and critical assessment of the various, rather heterogeneous theories in this field.

show abstract

“…Lack of this correlation is a consistent finding in major depression rated by Ham-D 14,17,22,[25][26][27][28]34 or Beck Depression Inventory. 23 An exception is provided by Gangadhar et al 21 Although Ham-D is included in several previous ERP-studies, only few of them have investigated its items separately to study their correlation to P300 in depression.…”

Section: Discussionmentioning

confidence: 89%

“…19,20 This amplitude reduction also is observed in major depression [16][17][18]21,22 and bipolar disorder, 18 but to a lesser degree than in schizophrenia, and in some studies 14,23,24 no significant differences in P300 are found between depressed patients and the control group. Psychotic symptoms, such as hallucinations and delusions, correlate negatively with P300 amplitude in severe depression, and the decreased P300 differentiates this state from a depression without these symptoms [24][25][26] ; a history of suicide attempts have been noted to have a similar relationship with P300 amplitude in depression. 27 Prolongation of P300 latency is an infrequent finding, but it has been connected to schizophrenia, [16][17][18]20 bipolar disorder, 18 and major depression.…”

mentioning

confidence: 90%

Enhanced Attention-dependent Auditory Processing by Electroconvulsive Therapy in Psychotic Depression

Nurminen

Valkonen‐Korhonen²,

Mervaala³

et al. 2005

The Journal of ECT

View full text Add to dashboard Cite

There is a lack of knowledge about the effect of electroconvulsive therapy (ECT) on auditory event-related potentials (ERPs) in severe psychotic depression. The aim of this study was to investigate both the effect of ECT on attention-dependent ERP (P300) and the correlation of P300 values with depression level. We recorded the auditory ERPs of 23 patients expressing psychotic symptoms and fulfilling the DSM-III-R criteria for treatment-resistant severe major depressive episode before and a week after successful bitemporal ECT. The clinical status was assessed with Hamilton (Ham-D) and Montgomery and Asberg (MADRS) depression scales. ECT was clinically very effective with these scales. On the level of auditory processing, ECT increased P300 amplitude with no significant effect on latency. Small amplitudes over the left hemisphere before treatment were associated with bigger Ham-D-score decrement. ECT produces a significant increase in brain activity at the level of attention-dependent auditory processing in severe depression. The change in electrical responses seems to represent a largely independent variable from the clinical assessment scales, even if the recovery rate was remarkable, because the change in overall symptom scores did not correlate with the P300 changes.

show abstract

A study of P300 in melancholic depression—Correlation with psychotic features

Cited by 51 publications

References 26 publications

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients

Theories of Delusional Disorders

Enhanced Attention-dependent Auditory Processing by Electroconvulsive Therapy in Psychotic Depression

Contact Info

Product

Resources

About