A study of oxidative stress induced by two polybrominated diphenyl ethers in the rotifer Brachionus plicatilis

Zhang, Jing; Wang, You; Sun, Kai-Ming; Fang, Kuan; Tang, Xuexi

doi:10.1016/j.marpolbul.2016.10.032

Cited by 35 publications

(8 citation statements)

References 42 publications

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“…Relative to the controls, the ROS levels were 1.99, 2.03, 2.68, 3.36, 4.24, and 5.14 times greater than that of the controls when P. tricornutum was exposed to 0.2, 0.3, 0.4, 0.5, 0.6, and 0.7 mg L − 1 BDE-15, respectively. The data were consistent with that reported by (Liu et al, 2020), who found that levels of ROS in P. tricornutum increased with increasing the concentrations of BDE-47, and the excessive ROS could lead to chloroplast membrane damage to aggravate the growth inhibition via a feedback loop; and by (Zhang et al, 2016), who observed that both BDE-47 and BDE-209 could induce the formation of ROS in the rotifer ovary, which was positively correlated with their concentrations. In addition, excessive ROS were reported to induce lipid peroxidation leading to the disruption of cell membrane, protein oxidation resulting in imbalance of enzymatic activities, nucleic acid oxidation followed by genetic mutation, and developmental toxicity (Saleh et al, 2016).…”

Section: Effects Of Bde-15 On Ros Level and Mda Contentsupporting

confidence: 91%

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Dong

Gao

Qian

et al. 2021

Preprint

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In this work, Phaeodactylum tricornutum was used to investigate the toxicity of 4,4'-dibromodiphenyl ether (BDE-15). Results showed that BDE-15 inhibited the photosynthetic activity and growth of P. tricornutum significantly with 24, 48, 72, and 96 h EC50 values of 1.03, 0.44, 0.41, and 0.42 mg L-1, respectively, indicating that it was a highly toxic substance. Moreover, BDE-15 could cause cell deformation, and a series of physiological, biochemical, and molecular changes in the cells. Under the exposure of BDE-15, contents of chlorophyll a and soluble protein decreased significantly, but reactive oxygen species (ROS) were accumulated in the algal cells, which may cause or intensify the peroxidation of membrane lipids. For alleviating the toxicity of excessive ROS, activities of antioxidant enzymes increased dramatically when this diatom was exposed to BDE-15. Thus, it is concluded that the overproduction of ROS may be regarded as one of the major factors in BDE-15 toxicity.

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Section: Effects Of Bde-15 On Ros Level and Mda Contentsupporting

confidence: 91%

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Dong

Gao

Qian

et al. 2021

Preprint

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“…Cells present a variety of defense mechanisms to neutralize the oxidative damage; antioxidant enzymes SOD and CAT constitute the first line of defense against the toxic effects of superoxide radicals (Zhang, Wang, Sun, Fang, & Tang, 2016). In spinosad-treated Sf9 cells, we observed a significant decrease in SOD and CAT activities (Figure 1(B,C)).…”

Section: Discussionmentioning

confidence: 75%

Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells

Yang

Gao

et al. 2017

Food and Agricultural Immunology

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Spinosad, a neurotoxic insecticide, is widely used for crop protection. In order to elucidate the effects of spinosad on oxidative stress and genotoxicity in Sf9 cells, the levels of lipid peroxidation, the activity of antioxidative enzymes, and DNA damage were measured. The results showed that spinosad caused a time-dependent increase in the formation of malondialdehyde and decrease in the activity of superoxide dismutase and catalase. Further studies confirmed that spinosad induced 8-oxoguanine accumulation in Sf9 cells, which is accompanied by increased expression of DNA repair enzymes (OGG1 and MTH1). The neutral comet assay revealed that spinosad induced significant timerelated increases of DNA double-strand breaks in Sf9 cells. Our results indicate that spinosad effectively induced oxidative stress and DNA damage in Sf9 cells. ARTICLE HISTORY

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“…A dominant PBDE congener in the environment, BDE-209 has been shown to cause oxidative stress in human erythrocytes, rats, earthworms, rotifers, goldfish, etc. (Feng et al, 2013;Milovanovic et al, 2015;Hu et al, 2016;Zhang et al, 2016a;Chi et al, 2017). Few studies have concerned on the oxidative stress caused by BDE-209 in marine bivalves, and should be supplemented.…”

Section: Effects Of Bde-209 On the Antioxidant Systemmentioning

confidence: 99%

“…Oxidative stress is a known pathway of pollutant toxicity, and studies have shown that BDE-209 can stimulate the production of reactive oxygen species (ROS), leading to oxidative stress (Milovanovic et al, 2015;Zhang et al, 2016a). The antioxidant system can scavenge ROS and protect the body from oxidative damage using enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx).…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of decabromodiphenyl ether affects the antioxidant system in the clam Mactra veneriformis

Zhu

Yang

et al. 2019

Environmental Toxicology and Pharmacology

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Antioxidant enzymes play vital roles against oxidative stress induced by decabromodiphenyl ether (BDE-209), being widespread in marine environment. However, the effect of BDE-209 on antioxidant enzymes remains poorly understood in marine bivalves. In this study, the clams Mactra veneriformis were exposed to 0.1, 1, and 10 μg/L BDE-209 for 7 days and then maintained in clean seawater for 3 days as the depuration. The bioaccumulation of BDE-209 and the effects on superoxide dismutase, catalase, and glutathione peroxidase were investigated. BDE-209 accumulation was concentration-dependent and decreased by 36%-52% after recovery. Malondialdehyde contents increased in a time-and dose-dependent manner. mRNA expression and activity of antioxidant enzymes changed with different patterns and recovered after depuration. These results suggested that antioxidant systems were triggered to protect the clams from oxidative damage caused by BDE-209. Thus, this research is helpful in elucidating the effect of BDE-209 on antioxidant system in marine bivalves.

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A study of oxidative stress induced by two polybrominated diphenyl ethers in the rotifer Brachionus plicatilis

Cited by 35 publications

References 42 publications

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Growth Inhibition and Oxidative Stress Caused by 4,4'-dibromodiphenyl Ether (BDE-15) on a Marine Diatom Phaeodactylum Tricornutum

Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells

Bioaccumulation of decabromodiphenyl ether affects the antioxidant system in the clam Mactra veneriformis

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