A Study of New Cytodiagnosis Report Format for Liquid-based Oral Cytology in Squamous Cell Carcinoma

Suzuki, Taiki; Kikuchi, Takayoshi; Yoshida, Yoshifumi; Sato, Kazumichi; Takano, Nobuo; Tanaka, Yoïchi; Nomura, Takeshi

doi:10.15214/jsodom.31.187

Cited by 7 publications

(7 citation statements)

References 5 publications

(7 reference statements)

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“…The diagnostic criteria of the JSCC take this point into account, but further examination of the diagnostic criteria is probably necessary in the future [ 8 ]. Suzuki et al reported that false-negative cytology was more likely to occur in cases where the exposed cell area for diagnosis was very small or where very limited growth was observed [ 14 ]. Because it was difficult to collect basal or parabasal-like atypical cells, cells useful for cytodiagnosis were not sampled, thus leading to false-negative results.…”

Section: Discussionmentioning

confidence: 99%

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

et al. 2020

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Background This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. Methods Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. Results Of NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. Conclusions LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings.

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Section: Discussionmentioning

confidence: 99%

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

et al. 2020

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“…A feature of the new criteria is the emphasis on the presence of high‐brightness OG‐stained atypical cells. And, preliminary studies for oral cancer of each clinical types have shown that the new criteria have high sensitivity and specificity 13,14 …”

Section: Discussionmentioning

confidence: 99%

“…Especially in lesions where LG atypical cells do not appear, high‐brightness Orange‐G (OG)‐stained atypical cells are important for diagnosis. According to the new criteria, the diagnostic accuracy was improved by separately evaluating LG and OG cell variants 13,14 . The feature of this new criteria reflects the cancerization form of the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

New oral cytodiagnostic criteria predict change to oral epithelial dysplasia (OED) and cancerization

Suzuki

Isaka

Hiraga

et al. 2021

Oral Science International

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Objectives The purpose of this retrospective observational study was to evaluate the specificity of the new oral cytodiagnostic criteria and whether the new criteria predict change to oral epithelial dysplasia (OED) and cancerization for leukoplakia and oral lichen planus (OLP). Study design Fifty‐three cases of leukoplakia without OED and 126 cases of OLP were included in this study. Liquid‐based cytology (LBC) was performed just before biopsy. We evaluated the specificity of the new oral cytodiagnostic criteria and the rates of change to OED and cancerization for each cytodiagnosis in leukoplakia and OLP. Results One hundred and seventy patients were negative for intraepithelial lesion or malignancy (NILM), seven had low‐grade squamous intraepithelial lesions (LSILs), and two were indefinite for neoplasia (IFN). The specificity was 95% and the rates of OED change and cancerization in the observation period were 3.4% and 1.7%. In leukoplakia, there was a significant difference in the rates of change to OED and cancerization between negative for intraepithelial lesion or malignancy (NILM) and LSIL (odds ratio: 12.9; 95% CI: 1.72‐96.73). Conclusions The new oral cytodiagnostic criteria have high specificity for oral mucosal lesions. And, it was suggested that the cases diagnosed with LSIL using new criteria have a high possibility of change to OED or cancerization in leukoplakia.

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“…The diagnostic criteria of the JSCC take this point into account, but further examination of the diagnostic criteria is probably necessary in the future. [8] Suzuki et al reported that false-negative cytology was more likely to occur in cases where the exposed cell area for diagnosis was very small or where very limited growth was observed [14]. Because it was di cult to collect basal or parabasal-like atypical cells, cells useful for cytodiagnosis were not sampled, thus leading to falsenegative results.…”

Section: Discussionmentioning

confidence: 99%

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

Sukegawa

Ono

Nakano

et al. 2020

Preprint

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BackgroundThis study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods.MethodsHistological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results.ResultsOf NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%.ConclusionsLBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings.

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A Study of New Cytodiagnosis Report Format for Liquid-based Oral Cytology in Squamous Cell Carcinoma

Cited by 7 publications

References 5 publications

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

New oral cytodiagnostic criteria predict change to oral epithelial dysplasia (OED) and cancerization

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

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