A study of neonatal hyperbilirubinemia in a tertiary care hospital

Context: Jaundice is a common problem and the most common risk factor for hospitalization during the neonatal period. Objective: The prevention of neonatal hyperbilirubinemia would not be possible without identifying its predisposing risk factors. The present systematic review study aims to determine the risk factors of neonatal jaundice. Data Sources: Databases including Science Direct, Cochrane Library, Web of Science (ISI), PubMed, and Google Scholar were searched to identify all eligible papers concerning the risk factors of neonatal hyperbilirubinemia. Study Selection: This systematic review was performed to review the causes and risk factors of neonatal hyperbilirubinemia. Finally, 18 articles were defined as eligible for further review. Data Extraction: The keywords included neonates, jaundice, hyperbilirubinemia, and risk factors. The inclusion criteria were studies determining jaundice risk factors, while papers with only published abstracts were excluded. Results: A total of 18 eligible articles (3 retrospective, 4 prospective, 10 cross-sectional, and 1 historical cohort) out of 421 retrieved articles were included in this review. The etiologic causes for neonatal jaundice were ABO incompatibility (24.6%), infection (including UTI and sepsis) (13.7%), G6PD deficiency (9.4%), Rh incompatibility (7%), and cephalohematoma (2.9%), while, known predisposing factors for neonatal jaundice included unknown (33.2%), low birth weight (30.9%), hyperbilirubinemia in siblings (22.7%), prematurity (20.1%), and infant of diabetic mother (6.7%). Conclusion: According to our review with considering the studies, the etiologic causes for neonatal jaundice are ABO incompatibility, infection (including UTI and sepsis), G6PD deficiency, Rh incompatibility, and cephalohematoma. While, known predisposing factors for neonatal jaundice include low birth weight, hyperbilirubinemia in siblings, prematurity, and infant of diabetic mother.

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“…Summary of studies on the causes and risk factors of neonatal jaundice(7,12,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) …”

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confidence: 99%

Risk Factors and Causes of Neonatal Hyperbilirubinemia: A Systematic Review Study

et al. 2020

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“…These both are noted as a significant risk factors in many studies. 9,19 Sepsis noted as a cause of neonatal jaundice in 7.94% babies and many studies also noted sepsis as a significant risk factor for jaundice 20 . Cephalhematoma (2.06%), hemolytic anemia (2.06%), G6PD deficiency (0.59%), hypothyroidism (0.29%) were least common causes noted in our study.…”

Section: Discussionmentioning

confidence: 99%

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2019

MIJOPED

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Background: Neonatal hyperbilirubinemia It may be physiological or pathological. Neonatal hyperbilirubinemia is a common condition requiring inpatient treatment and monitoring, and many times requires readmission to hospital. Estimated incidence of jaundice in neonates is 60% to 84% of late term and term infants. Present study was undertaken to study clinical profile of neonates with jaundice at our tertiary care center. Material and Methods: This prospective, observational study was conducted in neonates with jaundice admitted in NICU or neonatology ward during study period, with serum bilirubin more than 10 mg/dL. Results: During study period 340 newborns were considered for present study. 159 newborns (47 %) developed jaundice after 72 hours of birth. Only 14 % developed jaundice within 24 hours of birth. 56 % babies were male as compared to 44% female babies. Babies delivered at more than 37 weeks gestational age (70 %) were most common, while only 7% babies were delivered between 28-32 weeks gestational age. 2500-4000 gm birthweight babies were 66 %, while 28% babies had birthweight less than 2500 gm. Incidence of neonatal jaundice was 58%, 31% and 10% in vaginal delivery, caesarean section, instrumental delivery respectively. Physiological jaundice (36.17%), prematurity (13.53%), breast feeding (12.65%), idiopathic (12.35 %), were most common causes noted in our study. Conclusion: Male gender, 2500-4000 gm birthweight, vaginal delivery, physiological jaundice, prematurity were common causes associated with neonatal jaundice in our study. Parental counselling and monitoring of baby is most important in management of neonatal jaundice.

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“…Physiologic jaundice appears on the second and third days after birth and reaches its peak of 5 -6 mg/dL on the second to fourth days. After this, its level gradually de-creases to less than 2 mg/dL on the fifth day (3)(4)(5)(6). Jaundice is a common clinical problem during the neonatal period and can damage the neonate's brain in severe cases.…”

Section: Contextmentioning

confidence: 99%

Effect of Natural Products on Jaundice in Iranian Neonates

Fakhri

Farhadi

Mousavinasab

et al. 2019

Jundishapur J Nat Pharm Prod

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Context: Neonatal jaundice is the most common clinical problem in preterm and term neonates, and phototherapy is the most frequent treatment method for this condition. Researchers have long held that the use of natural products, especially medicinal plants, can reduce the incidence of neonatal jaundice, and in turn, the use of phototherapy in the treatment of neonatal jaundice in some countries including Iran. Objective: We aimed to carry out a systematic review on the effects of natural products on jaundice in Iranian neonates. Data Sources: Articles evaluating the effect of natural products on jaundice in Iranian neonates until the end of 2017 were searched using Google Scholar and IranMedex, SID, Magiran, IranDoc, Medlib, ScienceDirect, PubMed, Scopus, Cochrane, Embase, Web of Science, and Medline databases. Study Selection: Studies evaluating the effect of natural products on neonatal jaundice were included in the study. Studies were selected from the databases by screening titles, keywords and abstracts. Hence, all the articles which had the keywords in their titles, keywords or abstracts were selected. The inclusion criteria included: carrying out the study in Iran, being performed on neonates and using a natural product (herbal or non-herbal) to reduce neonatal jaundice. The articles that did not meet these criteria were excluded. Data Extraction: The ideal reporting items for systematic review and meta-analysis (PRISMA) checklist was used to evaluate the quality of the articles. Finally, a checklist was designed by the researchers to collect the data. The items of the checklist were the name of the first author of article, study objective, study setting, age, weight, number and gender of the neonates included, name, dose and frequency of the use of the natural product, route of delivery, and method of using the natural product (such as oral/nonoral). Results: The number of neonates enrolled in the 21 included studies was 2237. The effect of natural products on preventing neonatal jaundice was not statistically significant, but in some studies, the use of natural products in combination with phototherapy was found to be effective in the treatment of neonatal jaundice. Conclusions: The use of natural products for the prevention and treatment of neonatal jaundice requires further studies, but the usage of natural products such as medicinal plants like Cotoneaster with phototherapy could be possibly effective in reducing the duration of phototherapy and hospitalization.

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A study of neonatal hyperbilirubinemia in a tertiary care hospital

Cited by 18 publications

References 17 publications

Risk Factors and Causes of Neonatal Hyperbilirubinemia: A Systematic Review Study

Risk Factors and Causes of Neonatal Hyperbilirubinemia: A Systematic Review Study

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Effect of Natural Products on Jaundice in Iranian Neonates

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