A study of nanometre aggregates formation mechanism and antipyretic effect in Bai-Hu-Tang, an ancient Chinese herbal decoction

Yang, Ping; Li, Yingpeng; Lü, Shaowa; Sun, Yali; Zhang, Wanmeng; Wu, Jialin; Liu, Ting; Li, Yongji

doi:10.1016/j.biopha.2020.109826

Cited by 13 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, nanoaggregates were identified in Bai–Hu–Tang (BHT), a TCM decoction applied as an antipyretic. BHT NPs are the main antipyretic components of BHT . Ge–Gen–Qin–Lian decoction (GQD) has been applied to the treatment of type 2 diabetes and intestinal inflammation. , Lin et al showed that GQD nanoaggregates can increase BA absorption and improve its antidiabetic effect.…”

Section: Applications Of Natural Phytochemical-based Nanostructuresmentioning

confidence: 99%

Review of Natural Phytochemical-Based Self-Assembled Nanostructures for Applications in Medicine

Zhu

Zhang

Wang

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

The role of nanomedicine in disease diagnosis and treatment is indispensable. The future of nanomedicine in the pharmaceutical field is promising owing to its specificity and potency. However, its function and ultimate efficiency in clinical applications are still unsatisfactory, which can be attributed to the toxicity of nanomaterials caused by their nondegradability and accumulation in the body. To overcome the obstacles associated with the synthesized materials, researchers have focused on natural phytochemicals with good biodegradability, biocompatibility, and self-assembly capability. The structural diversity and combinational therapeutic effects of natural phytochemicals have broadened their nanomedical applications. This Review summarizes natural phytochemical-based nanostructures, including steroids, terpenoids, alkaloids, flavonoids, quinones, and polysaccharides and highlights their enormous application potential in nanomedicines. Additionally, in this Review, we summarize recent advances in nanostructures based on natural phytochemicals and introduce representative examples for drug-delivery, imaging, and theranostic applications in nanomedicine. Finally, we discuss the challenges in the rational design, synthesis, and fabrication of natural phytochemical-based nanostructures and propose feasible solutions for problems that need to be overcome to enable clinical translation.

show abstract

Section: Applications Of Natural Phytochemical-based Nanostructuresmentioning

confidence: 99%

Review of Natural Phytochemical-Based Self-Assembled Nanostructures for Applications in Medicine

Zhu

Zhang

Wang

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Polysaccharide, one of the primary active ingredients in the TCM, showed high anti-oxidant and immune activity [ 30 ]. As a hydrophilic polymer, when we introduce hydrophobic groups into polysaccharides, it can self-assemble into nanoparticles under the influence of system hydrophobic interaction and temperature [ 20 ]. The hydrophilic polysaccharide chain exists outside the nano-particle, and the hydrophobic groups are wrapped in the inner core.…”

Section: Discussionmentioning

confidence: 99%

“…Research on decoction nano-scale particles has attracted more and more attention. These studies mainly revolve around chemical composition, structure characterization [ 18 , 19 ], formation mechanism [ 20 ], improving the bioavailability of co-existing compounds, and their pharmaceutics application [ 21 ]. Clarifying the role of nano-scale particles in decoction is of great innovative significance for revealing the material basis of TCMD.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Natural Nanoparticles in Naoluo Xintong Decoction and Their Brain Protection Research

et al. 2022

View full text Add to dashboard Cite

Currently, researchers use modern analytical techniques in a unique perspective of physical pharmacy to analyze the phase composition of traditional Chinese medicine (TCM) and have discovered that natural nanoparticles commonly exist in decoctions. This study aims to isolate and characterize the structure and composition of nanoparticles in Naoluo Xintong (NLXT) and investigate whether the brain protection effect of NLXT is closely related to NLXT-Nanoparticles (NLXT-NPs). Firstly, the dialysis-centrifugation method was used to separate the nanoparticles and then their size distribution, potential, and morphology were characterized. In addition, infrared spectroscopy and ultra-high performance liquid chromatography-quadrupole-time of flight-mass spectrometer (UPLC-Q-TOF-MS) technology were used to analyze the composition of nanoparticles. As for the pharmacodynamic experiment, Sprague Dawley (SD) rats were randomly divided into sham, Middle cerebral artery occlusion (MCAO) model, NLXT, NLXT with nanoparticles removing (NLXT-RN), NLXT-RN+Nanoparticles (NLXT-RN+NPs), and NLXT-NPs groups. After administration, the neurological function, histopathological changes, oxidative stress, and apoptosis level were measured. Our research showed that NLXT-NPs are mainly composed of polysaccharides, proteins, and saponins, with typical characteristics of two hundred-nanometer size and negatively loaded. NLXT can improve nerve function, reduce oxidative stress, and inhibit cell apoptosis. However, removing nanoparticles can significantly reduce the brain-protective effect of NLXT, which indicates that NLXT-NPs play an essential role in the efficacy of NLXT.

show abstract

“…On the other hand, Ca 2+ , Mg 2+ , and Zn 2+ act as zeta-potential regulators that are adsorbed in the supramolecules to regulate the stability of the structure. There are many saponins in Glycyrrhizae , such as glycyrrhizic acid and glycyrrhetinic acid, which are important surface-active substances that can improve the solubility of mangiferin and neomangiferin and regulate the stability of the supramolecules [ 19 , 39 ]. An efficacy test showed that the antipyretic effect on rabbits and the effect of reducing the level of inflammatory factors in the serum were better for supramolecules than for the components in true-solution phase because of supramolecules was easily ingested by cells and targeted the brain and lungs, indicating that the supramolecules are key to the antipyretic mechanism of the Baihu decoction [ 40 ].…”

Section: Study Of the Supramolecules Of Traditional Chinese Medicine ...mentioning

confidence: 99%

Study on Supramolecules in Traditional Chinese Medicine Decoction

et al. 2022

View full text Add to dashboard Cite

With the application of the concept of supramolecular chemistry to various fields, a large number of supramolecules have been discovered. The chemical components of traditional Chinese medicine have various sources and unique structures. During the high-temperature boiling process, various active components form supramolecules due to complex interactions. The supramolecular structure in a traditional Chinese medicine decoction can not only be used as a drug carrier to promote the absorption and distribution of medicinal components but may also have biological activities superior to those of single active ingredients or their physical mixtures. By summarizing the relevant research results over recent years, this paper introduces the research progress regarding supramolecules in various decoctions, laying a foundation for further research into supramolecules in traditional Chinese medicine decoctions, and provides a new perspective for revealing the compatibility mechanisms of traditional Chinese medicine, guiding clinical medications, and developing new nanometers materials.

show abstract

A study of nanometre aggregates formation mechanism and antipyretic effect in Bai-Hu-Tang, an ancient Chinese herbal decoction

Cited by 13 publications

References 22 publications

Review of Natural Phytochemical-Based Self-Assembled Nanostructures for Applications in Medicine

Review of Natural Phytochemical-Based Self-Assembled Nanostructures for Applications in Medicine

Isolation and Characterization of Natural Nanoparticles in Naoluo Xintong Decoction and Their Brain Protection Research

Study on Supramolecules in Traditional Chinese Medicine Decoction

Contact Info

Product

Resources

About