A study of morbidity and drug utilization pattern in indoor patients of high risk pregnancy at tertiary care hospital

Patel, Kamlesh; Joshi, Harsh; Patel, Varsha J.

doi:10.5455/2320-1770.ijrcog20130922

Cited by 8 publications

(10 citation statements)

References 27 publications

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“…Our results are in accordance with previous Indian studies though some other studies report lower use of iron and folic acid during pregnancy. 8,14,17,18 The use of other drugs such as antihypertensive drugs, gastrointestinal drugs, uterine relaxants, antiepileptic drugs, hormones were largely problem oriented (Table 2) and is in accordance with earlier studies. 14 …”

Section: Discussionsupporting

confidence: 76%

“…Similar results have been reported by previous studies. 14 Most of the women attending this hospital come from lower socioeconomic class. High prevalence of poor nutritional status, vitamin and mineral deficiencies in this class warrants prophylactic use of vitamins and minerals.…”

Section: Discussionmentioning

confidence: 99%

“…Our finding largely conforms to previous studies. 14 For some of the medicinal products used in study population US-FDA pregnancy category was not available. Some of these products like arginine, essential amino acids, lactobacilli, disodium citrate though are not known to be harmful, specific safety data would be useful.…”

Section: Us-fda Pregnancy-drug Categoriesmentioning

confidence: 99%

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A study of drug utilization in indoor patients of high-risk pregnancy in a tertiary care hospital

Gaidhankar

Pore

Deokate

et al. 2016

Int J Basic Clin Pharmacol

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Background: High-risk pregnancy is an important determinant of drug use during pregnancy. The aim of study was to evaluate drug use pattern according to WHO core-drug prescribing indicators and US-FDA pregnancy category in indoor patients of high-risk pregnancy. Methods: It was a prospective, observational study. All high-risk pregnant women admitted to tertiary care hospital and willing to give consent were included. The data was collected from 290 patients over 12 months. The data was analysed to evaluate drug utilization according to WHO core drug use indicators and in relation to US-FDA pregnancy risk category. Results: The study found that 74.82% of women were between 20-30 years of age and were admitted during third trimester of pregnancy. The most commonly prescribed drug class was vitamins and minerals prescribed in 82.75% patients. Average number of drugs per encounter was 6.4. Percentage of drugs prescribed by generic name and from essential drug list was 73.07% and 77.07% respectively. Percentage of encounters with an antibiotic and an injection prescribed was 29.31% and 65.17% respectively. The prescription of drugs belonging to US-FDA pregnancy drug categories A, B and C were 92.06%, 86.55% and 4.82% respectively. Conclusions: Overall, the principles of rational prescribing were followed according to the various drug use indicators mentioned by the WHO and US FDA pregnancy risk category. Further studies are required to find out specific drug or drug therapy related problems and plan targeted interventions to improve drug use.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Us-fda Pregnancy-drug Categoriesmentioning

confidence: 99%

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A study of drug utilization in indoor patients of high-risk pregnancy in a tertiary care hospital

Gaidhankar

Pore

Deokate

et al. 2016

Int J Basic Clin Pharmacol

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“…These drugs were the least utilized from FDA pregnancy risk category drugs which was in line with that of the study conducted in Brazil (1.85%) [28] and in Coastal town, India (3.13%) [33] where medications used for pregnant women were from this category. A study conducted in Addis Ababa [34] had a higher value than this finding whereas a study conducted in Ahmedabad, India revealed that there was no drug used from this category [35]. In category D, there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of these drug in pregnant women despite potential risks [21].…”

Section: Discussionmentioning

confidence: 99%

Drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia: Consideration of toxicological perspectives

2018

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ObjectiveThis study is aimed to investigate drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia from March 1 to April 20, 2018.ResultA total of 369 pregnant women medical records were reviewed. The mean age of pregnant women was 24.34 (± 4.48) years and the majority of them were within the age of 18-25 years. About three-fourths (n = 277, 75.1%) of them were urban residents. Besides, 314 (85.1%) women had taken at least one drug with a total of 377 drugs prescribed. From which, supplemental drugs accounted majority of the drug therapy (84.88%) whereas non-supplemental drugs (15.12%) were used by 41 pregnant women during the review period. According to Food and Drug Administration FDA pregnancy risk classification, 320 (84.88%) drugs were prescribed from category A; 33 (8.75%) drugs were from category B; 19 (5.04%) drugs were from category C and 5 (1.33%) drugs were from category D. There was no drug prescribed from category X. As this result indicated, there is a decrease in the prevalence of drug use from Category A to X as the possibility of potential risk to fetus might outweigh the potential benefit to the mother. Some drugs were utilized from category D for treatment of chronic illnesses.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3966-5) contains supplementary material, which is available to authorized users.

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“…High prevalence of poor nutritional status, vitamin and mineral deficiencies in this class warrants prophylactic use of vitamins and minerals. 10 Accordingly most commonly used medications (in 100% of women) in the present study were iron, folic acid, calcium and multivitamin B complex (Table 5). Our results are in accordance with previous Indian studies.…”

Section: Discussionmentioning

confidence: 71%

A Study of drug utilization and clinical outcomes in indoor patients of hypertensive disorders of pregnancy

Gaidhankar

Ramanand

Kadam

et al. 2017

Int J Basic Clin Pharmacol

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INTRODUCTIONHypertension is one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality.Globally hypertensive disorders of pregnancy complicate approximately 5-10 % of pregnancies.1 Incidence of hypertensive disorders in India is found to be 10.08. 2According to The American College of Obstetricians and Gynaecologists (ACOG) practice bulletins, hypertensive disorders of pregnancy are classified as chronic hypertension, preeclampsia-eclampsia, preeclampsia superimposed upon chronic hypertension and gestational hypertension. Methods: This prospective, observational study in a tertiary care hospital was conducted in 150 pregnant women with hypertensive disorders of pregnancy from January 2014 and December 2014 who fulfilled the inclusion criteria. Antepartum and intrapartum care and the maternal and perinatal outcome were noted. The data was analyzed to evaluate clinical outcome and drug utilization according to WHO core drug use indicators. Results: Gestational hypertension was most common among hypertensive disorders of pregnancy seen in 62/150 (41.3%) women. The most common symptom was headache (48%) while sign noted was edema (69%). A total of 66% women had preterm delivery and 42% babies weighed less than 2.5 kg. Average number of drugs per encounter was 9.7. Percentage of drugs prescribed by generic name and from essential drug list was 64% and 79% respectively. The most commonly used drugs were vitamins and minerals prescribed in 100% patients followed by antihypertensive drugs (92%). The most common antihypertensive used were calcium channel blockers and anticonvulsant was magnesium sulphate. Conclusions: There was increased maternal and perinatal morbidity and operative intervention among pregnant women with hypertensive disorders of pregnancy. Most of the drugs were used appropriately and were in accordance with standard guidelines. The important problems identified were inappropriate use of antimicrobials, use of sublingual nifedipine and use of brand names in 1/4th of prescriptions.

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A study of morbidity and drug utilization pattern in indoor patients of high risk pregnancy at tertiary care hospital

Cited by 8 publications

References 27 publications

A study of drug utilization in indoor patients of high-risk pregnancy in a tertiary care hospital

A study of drug utilization in indoor patients of high-risk pregnancy in a tertiary care hospital

Drug utilization pattern among pregnant women attending maternal and child health clinic of tertiary hospital in eastern Ethiopia: Consideration of toxicological perspectives

A Study of drug utilization and clinical outcomes in indoor patients of hypertensive disorders of pregnancy

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