A study of microemboli monitoring of atherosclerotic thrombotic cerebral infarction and artery stenosis

Abstract

ABSTRACT. This study aimed to assess the relationship between the recurrence and prognosis of patients with acute middle cerebral artery infarction, atherosclerotic brain infarction, and the existence of microemboli. We continuously enrolled patients with acute atherosclerotic thrombotic cerebral infarction artery stenosis. We performed transcranial Doppler color ultrasound micro emboli monitoring, color Doppler ultrasound carotid artery tests, intracranial Microemboli monitoring study and carotid artery magnetic resonance angiography, impairment evaluation of nerve function, and registration of stroke recurrence and stroke mortality. Of the 49 patients enrolled in the study, 123 main arteries presented atherosclerotic stenosis or formed plaques, and 33 patients had symptomatic stenosis. Patients with symptomatic stenosis have a higher incidence of microemboli than patients with asymptomatic stenosis (P = 0.009). The microembolus-positive rate increased in patients with unstable plaques (P = 0.001). Patients who were microembolus-negative were more likely to show a neural function deficient NIHSS (National Institutes of Stroke Scale) score improvement than patients who were microembolus-positive at one week (P = 0.026). However, we found no significant difference between mRS (modified rankin scale) score (P = 0.319), relapse, and death (P = 0.179). The rate of microembolus-positivity increased in patients with atherosclerotic thrombotic cerebral infarction and unstable plaques. Patients who were microembolus-negative were more likely to show an improvement of neural function deficiency than patients with microembolus-positivity at one week (P = 0.026).

Transcranial Doppler and Microemboli Detection: Relationships to Symptomatic Status and Histopathology Findings

“…Our finding of no difference between symptomatic and asymptomatic status differ from others (Salem, et al 2011, Siebler, et al 1994, Sun, et al 2014, Tegos, et al 2001) in which microemboli were more prevalent in symptomatic patients. Our findings also differ from others (Sitzer, et al 1995) in that we did not see any macroscopic nor microscopic differences in plaque between the symptomatic and asymptomatic groups.…”

RETRACTED ARTICLE: Effects of BDNF-Transfected BMSCs on Neural Functional Recovery and Synaptophysin Expression in Rats with Cerebral Infarction

“…In the MR imaging, T2-weighted images showed high signal of infarcted tissue in the model group. MR imaging has always been a useful tool in monitoring development of CI [18]. Meanwhile, TTC staining of brain tissues showed visible white infarcted tissue at the left side rat brain arteries in the model group.…”

Transcranial Doppler Ultrasound Detection of Microemboli as a Predictor of Cerebral Events in Patients with Symptomatic and Asymptomatic Carotid Disease: A Systematic Review and Meta-Analysis

“…Nineteen studies, with a total of 5570 individual patients, reported stroke as an outcome along with data for TCD recording of microembolic signals (7)(8)(9)(10)13,16,(18)(19)(20)23,(27)(28)(29)(30)(31)(32)(33)(34). The sensitivity and specificity were 73.14 (95% CI 48.16 to 88.86) and 70.27 (95% CI 58.61 to 79.78)* respectively.…”