A study of lipid profile in non-diabetic chronic kidney disease

Ganta, Veeren; Yalamanchi, Radha Priya; Kc, Mahanta; Sahu, Biswajit; Raghvendar, Kota; Anusha, G.; Bachu, Bharadwaj; Reddy, C. Raghavendra

doi:10.18203/2349-3933.ijam20163732

Cited by 12 publications

(17 citation statements)

References 11 publications

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“…In CKD Registry of India 2007 8 , the percentages of male cases were 68.9 and female cases were 31.1. Similar results to current study were seen in studies by Abraham et al 11 and Ganta et al 12 The mean eGFR calculated by the CKD-EPI equation 1 19 showing results similar to our study. On basis of severity grades 62% of cases were in G5 grade and 34% of cases were in G4 grade as shown in Table 3.…”

Section: Discussionsupporting

confidence: 93%

“…These findings indicate a rise in serum total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins and a fall in high density lipoproteins in CKD with fall in eGFR. Similar changes in lipid profile were seen by Machnur and Chandrashekar, 15 Patel and Sirajwala, 9 Ganta V et al, 12 Attman, Samuelsson and Alaupovic, 16 Mannangi et al and Wang et al, 17 Paul and Kurien 18 in separate studies showed significant inverse correlation between triglyceride and GFR and significant positive correlation between high density lipoprotein and GFR (p= < 0.001). Table 7 depicted that comparing Mean ± S.D.…”

Section: Discussionsupporting

confidence: 60%

“…In CKD Registry India 2007, 50.3% cases were in G5 and 24% were in G4. In study by Ganta et al, 12 45.71% cases were in G5 and 37.14 % were in G4. These findings were similar to that in our study.…”

Section: Discussionmentioning

confidence: 86%

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Dyslipidaemia in CKD Patients and Its Correlation With Severity of Renal Dysfunction

Mohanty¹,

Acharya²,

Thatoi³

et al. 2018

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BACKGROUND Chronic kidney disease (CKD) is a significant global health problem with significant morbidity and mortality. Dyslipidaemia along with an abnormal apolipoprotein profile and composition is a common complication associated with the decline in eGFR in CKD. The association between abnormal lipid profile and severity of CKD has rarely been studied in a general population, especially in Indian setup and may have a future prognostic and management implication in patients with CKD. Aims and Objectives-To study the pattern of lipid abnormalities in CKD patients and to correlate with severity of renal dysfunction. MATERIALS AND METHODSA descriptive comparative study was done using 50 cases of CKD of > 15 years age, along with 30 age and sex matched controls excluding confounding factors like diabetes, HTN, thyroid abnormalities, heart diseases, infection, inflammatory diseases, smoking, alcoholism etc. History, general and systemic examination, routine blood parameters, ECG, USG abdomen pelvis, serum total cholesterol, LDL, HDL, VLDL and triglycerides were done. The eGFR was calculated according to the CKD-EPI equation. Statistical analysis was done using student's t-test, ANOVA, Bonferroni test, Mann-Whitney U test, Chi-square test and Pearson's correlation. P value < 0.05 was considered as statistically significant. RESULTSThe lipid profile in cases were TC: 184.96 ± 24.85 mg/dL; TGL: 148.10 ± 32.71 mg/dL; HDL: 32.38 ± 5.78 mg/dL; LDL: 122.82 ± 24.76 mg/dL; VLDL: 29.68 ± 6.54 mg/dL. Correlation between eGFR shows a significant negative correlation with TC (p= 0.007), TGL (p= 0.002), LDL (p= 0.000) and VLDL (p= 0.002) and positive correlation with HDL (p= 0.000). Comparison of lipid profile with grades of eGFR shows significant association with TGL (f= 3.804, p= 0.004), HDL (f= 18.099, p= 0.000), LDL (f= 3.793, p=0.004) and VLDL (f= 3.631, p= 0.005), but not with TC (f= 2.194, p= 0.064). CONCLUSIONIn CKD depending on severity there is a rise in TC, TGL, LDL, VLDL and a fall in HDL depending on severity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 60%

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Dyslipidaemia in CKD Patients and Its Correlation With Severity of Renal Dysfunction

Mohanty¹,

Acharya²,

Thatoi³

et al. 2018

jemds

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“…There was no statistical difference in lipid profile between A2 and A3 staging. (p value>0.05) Similar reports were revealed by Gantaet al 22 Present study showed positive correlation of lipid profile with HDL i.e. with decreasing GFR, HDL level was falling while total cholesterol, triglyceride, LDL and VLDL were showing negative correlation with decreasing GFR, their value increased.…”

Section: Discussionsupporting

confidence: 89%

A Study of Lipid Profile and Staging in Non-Diabetic Chronic Kidney Disease

Lahariya¹

2018

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“…Our study also demonstrated a higher proportion of male subjects diagnosed with CKD similar to previous Indian study. 2 91 patients showed dyslipidaemia constituting 67.91% of the patients. In other studies, Ashar Alam et al, which looked at the prevalence and risk factors of kidney disease in urban Karachi, 350 patients were studied, of which, 91.4% were nondiabetic showed that 54.3% patients had dyslipidaemia.…”

Section: Discussionmentioning

confidence: 98%