A Study of Irregular Antibodies in 200 Multi - Transfused Patients

Pimpaldara, Rakesh P.; Patel, Amol; Patel, Jitendra; Patel, Snehal G.; Pandya, Aarti; Wadhwani, Sangita

doi:10.14260/jemds/2015/1825

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…The specificity of most alloantibodies detected in this study was against the D system (77.8%), which is similar to previous reports of Thakral and coworkers (61%), Hmida and coworkers (59%), and Dhawan and coworkers (52%) . The transfusion of blood matched for D could prevent alloimmunization resulting in a significant difference in the alloimmunization rates . In our study anti‐D developed in 28.6% of all D– alloimmunized patients, followed by anti‐C, anti‐c, anti‐E, and anti‐Fya in 11.8% of alloimmunized patients.…”

Section: Discussionsupporting

confidence: 91%

“…12 The transfusion of blood matched for D could prevent alloimmunization resulting in a significant difference in the alloimmunization rates. 21,22 In our study anti-D developed in 28.6% of all D-alloimmunized patients, followed by anti-C, anti-c, anti-E, and anti-Fya in 11.8% of alloimmunized patients. The high rate of anti-D in D-patients in our study is likely related to transfusions of units with weak D antigens, as it is not mandatory in Egypt to test apparently D-donors for weak D. Hussein and Teruya 23 demonstrated an anti-D incidence of 63.5% in Egyptian D-children with thalassemia who received units for which weak D was not tested.…”

Section: Discussionsupporting

confidence: 50%

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Study of red blood cell alloimmunization risk factors in multiply transfused thalassemia patients: role in improving thalassemia transfusion practice in Fayoum, Egypt

et al. 2016

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The study reemphasizes the need for cost-effective strategy for thalassemia transfusion practice in developing countries. Red blood cell antigen typing before transfusion and issue of antigen-matched or antigen-negative blood can be made available to alloimmunized multiply transfused patients. Early institution of transfusion therapy after diagnosis is another means of decreasing alloimmunization.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 50%

Study of red blood cell alloimmunization risk factors in multiply transfused thalassemia patients: role in improving thalassemia transfusion practice in Fayoum, Egypt

et al. 2016

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“…[ 4 ] and Philip et al . [ 12 ] also observed significant association between gender and alloantibody formation. This finding is in concordance with our study.…”

Section: Discussionmentioning

confidence: 95%

“…Rate of alloimmunization was in concordance with the study done by Pimpaldara et al . [ 12 ] in which rate of alloimmunization was 7%.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of red cell alloimmunization in multi transfused patients at a Tertiary care teaching hospital

Handa

Kukar

Maharishi³

et al. 2020

J Family Med Prim Care

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Background: Red blood cell (RBC) alloimmunization is an immune response against foreign RBC antigens; this generally occurs after sensitization due to multiple blood transfusions and pregnancies. Antibody detection plays a critical role in transfusion medicine as it can detect irregular or unexpected antibodies. This study was done to know the frequency and specificity of unexpected red cell antibodies in the multitransfused patients. Materials and Methods: This prospective study was done in the Department of Immuno-Haematology and Blood Transfusion. Antibody screening of 100 multitransfused patients with initial negative antibody screen was carried out prior to compatibility testing and followed for a period of 12 months for each transfusion. Depending on the results, patients were given corresponding antigen-negative blood units. Results: In this study, the rate of alloimmunization was 7%. Total number of samples that were positive for irregular alloantibodies were 4 of 54 cases of thalassemia, that is, 7.4%, whereas 3 of 40, that is, 7.5%, cases of solid malignancies developed alloantibodies. None of the patients of chronic kidney disease formed any alloantibody. Anti-K antibody was the most frequent antibody detected in 3 of 7, that is, 42.8% patients. Anti-E was the second most frequent antibody observed in 2 of 7, that is, 28.57%. However, anti-c and anti-M were detected in one each of 7, that is, in 14.28% each. Conclusion: It is concluded here that red cell alloimmunization should not be overlooked in multitransfused patients. To avoid the effects of alloimmunization, routine RBC antibody screening at set time intervals after transfusion should be performed.

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Study of the Frequency and Specificity of Red Cell Antibodies in Patients with Hemoglobinopathies

Wilson

Masry

El-Ghamrawy

et al. 2023

Indian J Hematol Blood Transfus

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Patients with thalassemia and sickle cell disease (SCD) require blood transfusions as part of their supportive care. However, one of the most serious side effects of this treatment is the risk of red cell alloimmunization. The goal of this study was to assess the prevalence and Specificity of red cell alloimmunization in Egyptian thalassemia and sickle cell anaemia patients. This study included 200 multi transfused Egyptian patients, one hundred and forty patients with transfusion dependent thalassaemia and sixty patients with sickle cell anaemia, who were attending the Paediatric Children Hospital-Cairo University at the period from March 2019 to October 2019. Alloantibody identification was made by Diamed- ID microtyping system. In the studied groups both thalassemia and sickle patients, the prevalence of alloimmunization was 22/200 (11%) patients. The two most often alloantibodies were, antibodies against Kell antigen (37%) and against E antigen (30%). The prevalence of alloimmunization was more in females in comparison to males, but it did not reach statistical significance and patients with thalassemia major had higher alloimmunization rates than other studied groups but was not statistically significant. In the D negative patients in the research group, alloimmunization demonstrated a statistically significant difference (p = 0.01). Age, gender, age of transfusion onset and splenectomy were not contributing factors to the antibody presence in the group of patients being investigated. Before receiving blood transfusions, extended red blood cell phenotyping should be thought of as a crucial procedure for hemoglobinopathies patients who would likely have several transfusions. It is advised that haemoglobinopathies patients in Egypt be checked through phenotyping of RBC units for Kell and all Rh antigens to be phenotyped before starting transfusion in these patients which is also standard of care for these patients presently.

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A Study of Irregular Antibodies in 200 Multi - Transfused Patients

Cited by 6 publications

References 11 publications

Study of red blood cell alloimmunization risk factors in multiply transfused thalassemia patients: role in improving thalassemia transfusion practice in Fayoum, Egypt

Study of red blood cell alloimmunization risk factors in multiply transfused thalassemia patients: role in improving thalassemia transfusion practice in Fayoum, Egypt

Analysis of red cell alloimmunization in multi transfused patients at a Tertiary care teaching hospital

Study of the Frequency and Specificity of Red Cell Antibodies in Patients with Hemoglobinopathies

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