A Study of Intestinal Absorption in Dogs Following Massive Small Intestinal Resection and Insertion of an Antiperistaltic Segment

Stahlgren, LeRoy H.; Umana, Guillermo; Roy, Robert H.; Donnelly, Joseph E.

doi:10.1097/00000658-196209000-00015

Cited by 76 publications

(8 citation statements)

References 12 publications

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“…The relationship of small bowel transit time to absorption of fat, protein, and carbohydrates has not been thoroughly studied. Stahlgren in 1958 produced diarrhea, steatorrhea, and weight loss in dogs with ileal resection (20). The surgical placement of a short antiperistaltic segment to delay small bowel transit eliminated diarrhea, produced weight gain, and diminished steatorrhea.…”

Section: Resultsmentioning

confidence: 99%

Bile salt malabsorption in regional ileitis, ileal resection, and mannitol-induced diarrhea

Meihoff¹,

Kern²

1968

J. Clin. Invest.

185

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A B S T R A C T Fecal bile salt excretion was studied in healthy volunteers, patients with regional ileitis, and patients with ileal resection. 10 ,uc of carboxyl-14C-cholic acid was given orally. Stools and urine were collected daily for 5-10 days, the bile salts extracted, and the radioactivity assayed. Urinary excretion was negligible. All patients with ileal resection excreted bile salts in the feces significantly faster than controls, and five of the six excreted 50%o of the radioactivity within 24 hr.Their mean intestinal transit time was 5.6 hr compared to 26 hr for the controls. Two of the three patients with regional ileitis excreted bile salts almost as rapidly as patients with ileal resection. Vitamin B12 absorption was also defective in those patients, but the intestinal transit time was not decreased.To study the effect of rapid intestinal transit on bile salt excretion, four of the control subjects were given orally 1200 ml of 10% mannitol for 7 days, and the labeled cholic acid excretion rate was again studied. The mean intestinal transit time was markedly shortened, mild steatorrhea developed, and the fecal bile salt excretion rate increased slightly.It is concluded that ileal resection and ileal disease are major factors and rapid intestinal

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Section: Resultsmentioning

confidence: 99%

Bile salt malabsorption in regional ileitis, ileal resection, and mannitol-induced diarrhea

Meihoff¹,

Kern²

1968

J. Clin. Invest.

185

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“…She recovered fo llowing the reversal of a 7.5 cm segment of jejunum. Subsequently, Srahlgren (9) demonstrated that the fecal output of fat and, to a lesser degree, nitrogen, decreased with the insertion of an antiperistaltic segment in the jeju num of dogs. Us ing 3 co 4 cm paired proximal and distal reversed segments, Keller ( 10) proposed that the mechanism by which intestinal reversal worked was a prolongation of intestina l transit with an increase 111 the contact time of mucosaand luminalcontents.…”

Section: Slowing Intestinalmentioning

confidence: 99%

Short Bowel Syndrome: Surgical Therapy

Buie¹,

Thurston²,

Fedorak³

1990

Canadian Journal of Gastroenterology

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Many surgical solutions to short bowel syndrome have been proposed; h owever, none has proven robe uniformly successful. Some of these solutions, combined with optimal medical management, may represent the patient's only hope for survival without parenteral nutrition. Most forms of surgical therapy are supportive and aim at controll ing three basic pathophysiological defects: decreased intestinal transit time, gastric hypersecretion, and reduced functional mucosa! surface area. Conservative resection and, thus, prevention of short bowel synd rome rema ins the best form of treatment at present. In the fu ture, small bowel transplantation may prove to be an important advance in therapy; however, this remains largely experimental due to continued problems with rejection. Can

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“…Einerseits [5,23,36,40,42,45]. Dies wurde auch am h{enschen anl/il31ich einer gelaparotomie, 3 Jahre naeh an%iperi-staltischer D/inndarmzwischenschaltung, beobachtet [29].…”

Section: Literaturiibersiehtunclassified

Operative Versuche zur Verz�gerung der Darmpassage nach ausgedehnten Resektionen

Schima

1969

Arch. f. klin. Chir

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A Study of Intestinal Absorption in Dogs Following Massive Small Intestinal Resection and Insertion of an Antiperistaltic Segment

Cited by 76 publications

References 12 publications

Bile salt malabsorption in regional ileitis, ileal resection, and mannitol-induced diarrhea

Bile salt malabsorption in regional ileitis, ileal resection, and mannitol-induced diarrhea

Short Bowel Syndrome: Surgical Therapy

Operative Versuche zur Verz�gerung der Darmpassage nach ausgedehnten Resektionen

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