A study of increased levels of soluble vascular cell adhesion molecule-1 (SVCAM-1) in the cerebrospinal fluid of patients with multiple sclerosis and systemic lupus erythematosus

Abstract

The concentration of soluble vascular cell adhesion molecules (sVCAM-1) of serum and cerebrospinal fluid (CSF) was measured in clinically selected multiple sclerosis (MS) and systemic lupus erythematosus (SLE) patients, using an ELISA assay. The mean sVCAM-1 concentration in the serum of SLE patients was higher than normal. The mean CSF sVCAM-1 concentration was increased in the MS as in the SLE group. On analysis, the data suggests that there are some similarities in the immunological effects of these two different diseases of the central nervous system. A longitudinal analysis of the CSF is requested.

Soluble adhesion molecule levels, neuropsychiatric Lupus and Lupus-related damage

“…We found elevated levels of ICAM-1, VCAM-1 and E-selectin in our cohort of SLE patients as compared to normal control values. Others studies have also detected elevated levels of one or more of these when compared to controls (16,18,20,21,23,24,(32)(33)(34)(35)(36). High levels of all soluble adhesion molecule levels were found in Mexican American lupus patients, as compared with Caucasian and African American lupus patients and Mexican American control subjects.…”

“…These findings support two other small studies that found a relationship between soluble adhesion molecule levels and neurological disease. Baraczka and colleagues previously described the appearance of new neurological symptoms in association with an increase in serum sVCAM-1 levels (18). Spronk and colleagues also found elevated levels of sVCAM-1 in 7 patients with some type of CNS involvement (22).…”

“…Adhesion molecules are crucial for cellular communication between immunocompetent cells, and play a key role in cellular activation and adhesion (18). ICAM-1 supports the adhesion of all leukocytes and is expressed in activated endothelial cells, smooth muscle cells and in human atherosclerotic lesions.…”

“…The expression of adhesion proteins on endothelial cells appears to up-regulate, and facilitate lymphocyte entry into the CNS in many autoimmune diseases (10)(11)(12)(13)(14)(15)(16)(17). Shedding of the active from of these molecules occurs, and soluble levels can be measured in both serum and cerebrospinal fluid (CSF) (18,19). Although adhesion molecules have been implicated as serological markers in SLE patients with skin disease (20), renal disease (21,22) and other non-nervous system organ involvement (22)(23)(24), few other studies have evaluated soluble adhesion molecule levels in relationship to NPSLE manifestations.…”

Vascular cell adhesion molecule 1 (CD106): A multifaceted regulator of joint inflammation

“…Because VCAM-1-deficient mice die during embryogenesis (77,78), it is impossible to perform experiments using gene knockout animals. Increased sVCAM-1 is found in the serum and synovial fluid of patients with RA (79)(80)(81), the serum of patients with primary antiphospholipid syndrome (APS) or APS in conjunction with systemic lupus erythematosus (SLE) (82), and the cerebrospinal fluid of patients with SLE and multiple sclerosis (83). Elevated serum concentrations of sVCAM-1 correlate strongly with disease activity in lupus nephritis (84,85).…”