“…Mutations in genes directly involved in pigmentation (c‐kit, tyrosinase, TRP‐1, MATP or P gene) have been identified in hypopigmented diseases such as piebaldism and albinism, while mutations in cytoskeletal proteins (keratin 5, 14) have been identified in hyperpigmented diseases such as DDD (Liao et al, ), Galli–Gali disease (Reisenauer et al, ), epidermolysis bullosa associated with mottled pigmentation (EBS‐MP) (Geller, Kristal, & Morel, ; Horiguchi et al, ; Irvine, McKenna, Jenkinson, & Hughes, ), Naegeli–Franceschetti–Jadassohn syndrome, and dermatopathia pigmentosa reticularis (Lugassy et al, ). Interestingly, Grosshans and colleagues and Zhang and Zhu (Grosshans, Geiger, Hanau, Jelen, & Heid, ; Zhang & Zhu, ) using electron microscopy observed a large number of single melanosomes characteristic of phototype VI skin in the lesional skin of patients with DDD.…”