A Study of Illness in a Group of Cleveland Families

Jordan, William S.; Denny, Floyo W.; Badger, George F.; Curtiss, Constance; Dingle, John H.; Oseasohn, Robert; Stevens, David A.

doi:10.1093/oxfordjournals.aje.a119962

Cited by 50 publications

(36 citation statements)

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“…Excluded studies and reasons for exclusion are listed in Data S2. Overall risk of bias was minimal in two studies [37], [39], low in 17 studies [5], [15], [16], [19]–[25], [29]–[31], [33], [38], [40], [41], moderate in eight studies [9], [17], [26], [27], [32], [34]–[36], and high in two studies (Table S4) [18], [28].…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies (38 influenza seasons, 13,373 participants) assessed influenza rates in HCWs [9], [19], [20], [27]–[29], [36], [40], [41], seven studies (20 influenza seasons, 3,642 participants) enrolled families with children [5], [21]–[24], [26], [31], and 14 studies (39 influenza seasons, 41,230 participants) assessed influenza rates in adults not working in healthcare settings and irrespective of family status [15]–[18], [20], [25], [30], [32]–[35], [37]–[39]. From these, one study provided data for both HCWs and non-HCWs without comparison [20].…”

Section: Resultsmentioning

confidence: 99%

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Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

et al. 2011

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BackgroundWorking in healthcare is often considered a risk factor for influenza; however, this risk has not been quantified. We aimed to systematically review evidence describing the annual incidence of influenza among healthy adults and healthcare workers (HCWs).Methods and FindingsWe searched OVID MEDLINE (1950 to 2010), EMBASE (1947 to 2010) and reference lists of identified articles. Observational studies or randomized trials reporting full season or annual influenza infection rates for healthy, working age adult subjects and HCWs were included. Influenza infection was defined as a four-fold rise in antibody titer, or positive viral culture or polymerase chain reaction.From 24,707 citations, 29 studies covering 97 influenza seasons with 58,245 study participants were included. Pooled influenza incidence rates (IR) (95% confidence intervals (CI)) per 100 HCWs per season and corresponding incidence rate ratios (IRR) (95% CI) as compared to healthy adults were as follows. All infections: IR 18.7 (95% CI, 15.8 to 22.1), IRR 3.4 (95% CI, 1.2 to 5.7) in unvaccinated HCWs; IR 6.5 (95% CI, 4.6 to 9.1), IRR 5.4 (95% CI, 2.8 to 8.0) in vaccinated HCWs. Symptomatic infections: IR 7.5 (95% CI, 4.9 to 11.7), IRR 1.5 (95% CI, 0.4 to 2.5) in unvaccinated HCWs, IR 4.8 (95% CI, 3.2 to 7.2), IRR 1.6 (95% CI, 0.5 to 2.7) in vaccinated HCWs.ConclusionsCompared to adults working in non-healthcare settings, HCWs are at significantly higher risk of influenza.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

et al. 2011

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“…The excesses for 5-14 year old males, 25 and five per 10,000 for high-risk and non-high-risk categories respectively, reached statistical significance. The small excesses experienced by [5][6][7][8][9][10][11][12][13][14] year old females were not statistically significant. Three of the children with influenza-related discharges died during the hospitalization.…”

Section: Resultsmentioning

confidence: 99%

“…The pediatric population, especially [5][6][7][8][9][10][11][12][13][14] year old males, experienced excess influenza-related hospitalizations, primarily for bronchitis and pneumonia, during epidemic periods compared with non-epidemic periods. The higher influenza-related hospitalization rate in boys than in girls is consistent with the sex differences reported for respiratory illness incidence. "…”

Section: Discussionmentioning

confidence: 99%

Impact of type A influenza on children: a retrospective study.

Mullooly¹,

Barker²

1982

Am J Public Health

115

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Excess morbidity was studied during influenza A epidemics among children in a large prepaid group practice program. Excess rates of hospitalization for influenza-related conditions, primarily pneumonia and bronchitis, ranged from 5 per 10,000 (95 per cent confidence limits (CL): 1 to 9) for non-high-risk children to 29 per 10,000 (95 per cent CL: 5 to 53) for children with high-risk conditions. The relative increases in hospitalization rates were greatest for 5-14 year old boys: 278 per cent and

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“…We owe a large debt to those investigators, including Dr. William S. Jordan (with whom Epstein conferred), who conducted the careful prospective surveillance of the Cleveland Family Study and left a legacy of invaluable archived specimens and data [3].…”

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confidence: 99%

Influenza Immunity: New Insights from Old Studies

Kilbourne

2006

J INFECT DIS

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A Study of Illness in a Group of Cleveland Families

Cited by 50 publications

References 0 publications

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

Impact of type A influenza on children: a retrospective study.

Influenza Immunity: New Insights from Old Studies

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