A study of idiopathic generalised epilepsy in an Irish population

Mullins, Gerard; O’Sullivan, Sean S.; Neligan, Aidan; McCarthy, Andréa; McNamara, Brian; Galvin, R.; Sweeney, Brian

doi:10.1016/j.seizure.2006.12.007

Cited by 30 publications

(18 citation statements)

References 11 publications

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“…Our results showed that more females complained of more than one seizure type and the same results were shown by Mullins and his colleagues [27]; however, they reported multi-seizure (> 2) type to be equal in both sexes, an observation that we recommend to be further studied. They also found that idiopathic generalized epilepsy (IGE) is more common in females; in our cohort, this was true for JME, IGTC, and TLE, but juvenile absence epilepsy (JAE) was more common in males (p = 0.02).…”

Section: Seizure Types and Epilepsy Classificationsupporting

confidence: 90%

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Kishk

Mourad

Ibrahim

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: Epilepsy is one of the most common neurological conditions. We aimed to identify sex differences in the demographic, clinical features, and treatment strategies in epileptic patients. Objectives: To analyze and compare the differences in the impact of epilepsy on the socio-demographic characteristics of male and female patients along with gender differences in various types of epilepsies and treatment strategies. Material and methods: A record-based study for 1000 individuals attending the epilepsy outpatient clinic. The medical records were reviewed through a predesigned questionnaire to obtain all relevant data. Statistical analysis: Data was summarized using range, mean, standard deviation, and median interquartile range for quantitative variable or frequency and percentage for the qualitative ones. Comparison between groups was done using chi-square test. Results: Females were more illiterate and unemployed compared to males. Tonic-clonic seizures were more frequent in males. Specific epileptic syndromes as juvenile myoclonic epilepsy (JME) were more frequent in females (p = 0.01). More males had an underlying secondary etiology (p = 0.001). The most common drug used was valproate (51.2%) which was more utilized by males. Conclusions: Significant differences between both sexes were observed in certain social impacts in addition to seizure syndromes, etiology, and drug utilization.

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Section: Seizure Types and Epilepsy Classificationsupporting

confidence: 90%

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Kishk

Mourad

Ibrahim

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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“…In this large cohort of patients, we observed that IGE‐GTCS is the most common seizure type among patients with IGE syndromes. This is consistent with that in previous studies . In our study, 86% of the patients reported experiencing GTCSs at some time during their disease; this rate was 73% in an Irish study .…”

Section: Discussionsupporting

confidence: 93%

“…This is consistent with that in previous studies . In our study, 86% of the patients reported experiencing GTCSs at some time during their disease; this rate was 73% in an Irish study . In the current study, we showed that the chance of experiencing GTCSs is a function of the duration of disease in patients with IGEs; therefore, the observed difference between our study and that Irish study could be due to the different durations of disease between the study populations.…”

Section: Discussionsupporting

confidence: 91%

Tonic‐clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome

Asadi‐Pooya

Homayoun

2020

Acta Neurol Scand

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Purpose We investigated the prevalence of generalized tonic‐clonic seizures (GTCSs) in patients with idiopathic generalized epilepsy (IGE) and the risk factors associated with them. We also studied the seizure outcome in patients with IGEs. Methods In this retrospective study, all patients with a diagnosis of IGE were recruited at the epilepsy clinic at Shiraz University of Medical Sciences, from 2008 through 2019. Age, gender, age at seizure onset, seizure type(s), EEG findings, and seizure outcome of all patients were registered. Results A total of 601 patients with IGE were studied; 516 patients (86%) had GTCSs. The ROC curve showed that reporting GTCSs was significantly associated with the time since the start of the disease (P = .0001; area under the curve = 0.71 [95% CI: 0.66‐0.76]; a cutoff point of 4 years [sensitivity = 61% and specificity = 76%]). Age at onset was 3.3 years later in patients with GTCSs compared with that in patients without GTCSs. Generalized spike‐wave complexes during interictal EEG recording were more frequently observed among patients without GTCSs. Generalized tonic‐clonic seizures were significantly associated with experiencing seizure‐related injuries. Valproate reduced the risk of experiencing GTCSs significantly (OR: 0.58; 95% CI: 0.34‐0.99; P = .04). Conclusion Generalized tonic‐clonic seizures do not affect the seizure outcome in patients with IGEs per se, but how we manage them significantly affects the seizure outcome in these patients. Failure to prescribe valproate for women with IGE, particularly when another first‐line treatment has failed, may not be in a patient's best interests.

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“…The diagnosis of IGE is based on strict clinical guidelines and electroencephalogram (EEG) as proposed by the International League Against Epilepsy (ILAE). IGE is more common in the first or second decade of life; although, it may be present in any ages (3,4). The patients suffer from epilepsy, might return to normal life situation after surgical operations on the seizure foci resistant against drug treatment.…”

Section: Introductionmentioning

confidence: 99%

Exploring Changes in Thalamus Metabolites as Diagnostic Biomarkers in Idiopathic Generalised Epilepsy Patients Using Magnetic Resonance Spectroscopy

Abedi-Firouzjah

Rostamzadeh

Banaei

et al. 2020

MJMS

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Introduction: Idiopathic generalised epilepsy (IGE) refers to a group of epilepsies resulting from the activation of neurons in the whole brain. This study aimed to evaluate the metabolite changes in thalamus as diagnostic biomarkers in IGE patients compared to healthy individuals using magnetic resonance spectroscopy (MRS) technique.Methods: The MRS was performed on 35 IGE patients (26 women and 11 men) with average age of 32 (ranged from 18 to 43) and 35 healthy individuals (13 women and 22 men) with average age of 31 (ranged from 21 to 50) as the control group. The levels of N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) were measured using MRS. The NAA/Cr and NAA/Cho ratios were calculated for all participants. These values were statistically compared using t-test between the groups.Results: The NAA had significant lower values in IGE patients, 9.6 (SD = 0.8) and 9.9 (SD = 0.7) for right and left thalamus, respectively, compared to 10.9 (SD = 0.9) and 10.7 (SD = 0.9) in control group. The Cr values in the left side of thalamus were significantly higher in IGE patients (6.7 [SD = 0.8] versus 5.8 [SD = 0.5]); however, there was no difference in right thalamus. Measurements showed no difference for amounts of Cho between the groups in both sides of thalamus. The NAA/Cr ratio was 1.48 (SD = 0.14) and 1.48 (SD = 0.16) for right and left thalamus, respectively, in IGE patients in comparison with 1.83 (SD = 0.2) and 1.86 (SD = 0.26) in controls. There was no meaningful variation between the NAA/Cho ratio of the right and left thalamus among the groups.Conclusion: Thalamic NAA, Cr and NAA/Cr ratio values in IGE patients showed statistical differences compared to healthy individuals. Evaluating metabolites variations in thalamus using MRS is suggested for differentiating IGE patients from healthy individuals.

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A study of idiopathic generalised epilepsy in an Irish population

Cited by 30 publications

References 11 publications

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Tonic‐clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome

Exploring Changes in Thalamus Metabolites as Diagnostic Biomarkers in Idiopathic Generalised Epilepsy Patients Using Magnetic Resonance Spectroscopy

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