A study of human colonic motility in healthy and constipated subjects using the wireless capsule

Lü, Li; Yan, Guozheng; Sun, Jingjing

doi:10.1016/j.compbiomed.2015.07.011

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…One limitation of this technique, however, is that the patient is required to wear a radiofrequency receiver for 5 days or until the capsule has been defecated. 6,46 Nuclear scintigraphy is a less widely available method of studying colonic transit time and is more costly than traditional radiopaque marker ingestion; however, scintigraphy requires only 24 to 48 hours to complete. 4,8 Typically the radionucleotide 111-diethylenetriamine pentaacetic acid ( 111 In-DTPA) is given in a resin-coated capsule which dissolves in the distal ileum at a pH of 7.4.…”

Section: Workup and Diagnostic Modalitiesmentioning

confidence: 99%

“…As discussed earlier, a variety of methods including radiopaque marker studies, nuclear scintigraphy, barium suspension ingestion tests, and wireless motility capsule studies may be used to diagnose segmental areas of inertia. 4,6,43,44,46 Reports concerning outcomes after segmental colectomy in individuals with proven discrete areas of colonic inertia are conflicting. 72,81,84 Lundin et al found that 23 out of 28 patients who underwent segmental resection were "pleased with their outcome."…”

Section: Surgical Managementmentioning

confidence: 99%

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Functional Disorders: Slow-Transit Constipation

Tillou

Poylin

2016

Clinics in Colon and Rectal Surgery

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Constipation is a very common complaint, with slow-transit constipation (STC) accounting for a significant proportion of cases. Old age, female gender, psychiatric illness, and history of sexual abuse are all associated with STC. The exact cause of STC remains elusive; however, multiple immune and cellular changes have been demonstrated. Diagnosis requires evidence of slowed colonic transit which may be achieved via numerous modalities. While a variety of medical therapies exist, these are often met with limited success and a minority of patients ultimately require operative intervention. When evaluating a patient with STC, it is important to determine the presence of concomitant obstructed defecation or other forms of enteric dysmotility, as this may affect treatment decisions. Although a variety of surgical procedures have been reported, subtotal colectomy with ileorectal anastomosis is the most commonly performed and well-studied procedure, with the best track record of success.

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Section: Workup and Diagnostic Modalitiesmentioning

confidence: 99%

Section: Surgical Managementmentioning

confidence: 99%

Functional Disorders: Slow-Transit Constipation

Tillou

Poylin

2016

Clinics in Colon and Rectal Surgery

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Minimally invasive wireless motility capsule to study canine gastrointestinal motility and pH

Warrit

Boscán

Ferguson

et al. 2017

The Veterinary Journal

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Analysis of the Chaotic Characteristics of Human Colonic Activities and Comparison of Healthy Participants to Costive Subjects

Lü

Yan

Zhao

et al. 2016

IEEE J. Biomed. Health Inform.

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Constipation is a common yet distressing disease that has high rates of morbidity and impacts patients' quality of life. However, there is no perfect method to distinguish costive patients from healthy subjects. Is there chaos in human colonic activities? Are there any differences for the chaos indicators of colonic activities between healthy and costive subjects? Can these indicators distinguish patients with constipation from healthy subjects? To answer these questions, colonic pressure data from 16 healthy subjects and 48 patients with constipation were analyzed using the chaos theory. Three chaotic indicators [i.e., the largest Lyapunov exponent (LyE), correlation dimension (CorDim), and Kolmogorov entropy (KoEn)] were calculated and compared between groups with the Wilcoxon rank sum test. As a result, the LyE was greater than zero and the CorDim was fractioned, which showed that human colonic activities have clear chaotic characteristics. Statistically significant differences were observed between groups for CorDim (p < 0.05), whereas LyE did not show statistically significant differences between groups. The chaotic indicator of CorDim was able to differentiate between patients with constipation and healthy subjects. The chaos theory provides a new method for learning the nonlinear dynamics of human gastrointestinal activities.

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A study of human colonic motility in healthy and constipated subjects using the wireless capsule

Cited by 5 publications

References 41 publications

Functional Disorders: Slow-Transit Constipation

Functional Disorders: Slow-Transit Constipation

Minimally invasive wireless motility capsule to study canine gastrointestinal motility and pH

Analysis of the Chaotic Characteristics of Human Colonic Activities and Comparison of Healthy Participants to Costive Subjects

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