A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…These materials have been extensively studied; they appear to be the only synthetic and biodegradable polymers with an extensive FDA approval history [46,105,[121][122][123][124][125]. They are biocompatible, mostly non-inflammatory, as well as degrade in vivo through hydrolysis and possible enzymatic action into products that are removed from the body by regular metabolic pathways [45,100,105,[125][126][127][128][129][130]. Besides, they might be used for drug-delivery purposes [131].…”

“…The combination of calcium orthophosphates and polymers into biocomposites has a twofold purpose. The desirable mechanical properties of polymers compensate for a poor mechanical behavior of calcium orthophosphate bioceramics, while in turn the desirable bioactive properties of calcium orthophosphates improve those of polymers, expanding the possible uses of each material within the body [127][128][129][228][229][230][231]. Namely, polymers have been added to calcium orthophosphates in order to improve their mechanical strength [127,228] and calcium orthophosphate fillers have been blended with polymers to improve their compressive strength and modulus, in addition to increase their osteoconductive properties [48,129,137,[232][233][234][235][236].…”

“…Another group used processing conditions to achieve a better adhesion of the filler to the matrix. Ignjatovic et al [127,128,259] prepared poly(L-lactic acid) (PLLA)/HA composites by pressing blends of varying PLLA and HA content at different temperatures and pressures. They found that maximum compressive strength was achieved at *15 wt% of PLLA.…”

Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

“…This indicates that the osteoconductive effect of the biomaterial, similar to the examined ones, is necessary for higher levels of osteogenesis and complete healing. In the subgroup where HAp-PLLA composite was implanted, 24 weeks after implantation, besides intensive formation of a new bone, increased binding, as well as migration and distribution of vascular and osteogenic cells within remnants of implanted material were noticed, which confirmed the osteoconductive effect of that biocomposite [9][10][11][12][13][14].…”

The Formation and Characterization of Nanocrystalline Phases by Mechanical Milling of Biphasic Calcium Phosphate/Poly-L-Lactide Biocomposite

“…7(a) shows all characteristic bands for PLLA. [37][38][39][40][41] The stretching mode of C=O group at 1755 cm À1 is detected. The bending modes of CH 3 group at 1381 and 1451 cm À1 and stretching modes of C-H group at 2994 and 2943 cm À1 are also present.…”