A Study of Glycemic Response to Corinthian Raisins in Healthy Subjects and in Type 2 Diabetes Mellitus Patients

Kanellos, P.; Kaliora, Andriana C.; Liaskos, Christos; Tentolouris, Nikolaοs; Perrea, Despina; Karathanos, Vaios Τ.

doi:10.1007/s11130-013-0348-y

Cited by 31 publications

(26 citation statements)

References 16 publications

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“…When the GI was investigated in three different groups (sedentary, aerobically trained or pre-diabetic subjects), no significant differences were found among groups, even though the GI (55–69) it seemed moderate for aerobically trained adults, and low (GI, ≤55) for the other groups [ 110 ]. Kanellos and collaborators found a moderate GI of raisins in healthy and T2D subjects [ 111 ], whereas Esfahani et al found that raisins were low-GI and glycaemic load (GL) foods in healthy subjects [ 112 ]. Recently, researchers have found that even though the same available CHO content from raisins and glucose generated a similar postprandial response, raisins significantly modulated the levels of GIP, ghrelin and ghrelin/obestatin ratio, with important implications in terms of appetite regulation and overall insulin secretion [ 113 ].…”

Section: Human Clinical Trialsmentioning

confidence: 99%

Nuts and Dried Fruits: An Update of Their Beneficial Effects on Type 2 Diabetes

et al. 2017

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Nuts and dried fruit are essential foods in the Mediterranean diet. Their frequent consumption has been associated with the prevention and/or the management of such metabolic conditions as type 2 diabetes (T2D), metabolic syndrome and cardiovascular diseases. Several previous reviews of epidemiological studies and clinical trials have evaluated the associations of nuts and/or dried fruit with various metabolic disorders. However, no reviews have focused on the mechanisms underlying the role of nuts and/or dried fruit in insulin resistance and T2D. This review aims to report nut and dried-fruit nutritional interventions in animals and humans, and to focus on mechanisms that could play a significant role in the prevention and treatment of insulin resistance and T2D.

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Section: Human Clinical Trialsmentioning

confidence: 99%

Nuts and Dried Fruits: An Update of Their Beneficial Effects on Type 2 Diabetes

et al. 2017

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“…Dried fruits show promising potential for blood glucose management. Previous trials conducted in individuals with and without diabetes have shown dried fruits (including dates, apricots, raisins, and sultanas) to have a low (≤55) to medium (56–69) glycemic index (GI) 1–7 and to have beneficial effects on postprandial glucose 3,6,8–11 and insulin 3,6,11 levels, as well as HbA 1c 8 compared to high GI foods (e.g., crackers, cookies, white bread, glucose solution). However, the effect of combining dried fruits with high GI foods has not been adequately addressed.…”

Section: Introductionmentioning

confidence: 99%

Effect of dried fruit on postprandial glycemia: a randomized acute-feeding trial

et al. 2018

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Background/ObjectivesTo investigate the effect of dried fruit in modifying postprandial glycemia, we assessed the ability of 4 dried fruits (dates, apricots, raisins, sultanas) to decrease postprandial glycemia through three mechanisms: a glycemic index (GI) effect, displacement effect, or ‘catalytic’ fructose effect.Subjects/MethodsWe conducted an acute randomized, multiple-crossover trial in an outpatient setting in 10 healthy adults. Participants received 3 white bread control meals and 12 dried fruit test meals in random order. The test meals included each of 4 dried fruits (dates, apricots, raisins, sultanas) alone (GI effect), 4 of the dried fruits displacing half the available carbohydrate in white bread (displacement effect), or 4 of the dried fruits providing a small ‘catalytic’ dose (7.5 g) of fructose added to white bread (‘catalytic’ fructose effect). The protocol followed the ISO method for the determination of GI (ISO 26642:2010). The primary outcome was mean ± SEM GI (glucose scale) for ease of comparison across the three mechanisms.ResultsTen healthy participants (7 men, 3 women; mean ± SD age and BMI: 39 ± 12 years and 25 ± 2 kg/m2) were recruited and completed the trial. All dried fruit had a GI below that of white bread (GI = 71); however, only dried apricots (GI = 42 ± 5), raisins (GI = 55 ± 5), and sultanas (51 ± 4) showed a significant GI effect (P < 0.05). When displacing half the available carbohydrate in white bread, all dried fruit lowered the GI; however, only dried apricots (GI = 57 ± 5) showed a significant displacement effect (P = 0.025). None of the dried fruits showed a beneficial ‘catalytic’ fructose effect.ConclusionsIn conclusion, dried fruits have a lower GI and reduce the glycemic response of white bread through displacement of half of the available carbohydrate. Longer-term randomized trials are needed to confirm whether dried fruit can contribute to sustainable improvements in glycemic control.Trial registrationClinicalTrials.gov identifier, NCT02960373

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“…This increase persisted in both the sensitivity and per-protocol analyses. Dried fruits have a low to moderate glycaemic index, and the acute glycaemic response to carbohydrate-rich meals is attenuated by replacement of refined starches with dried fruits (46)(47)(48)(49)(50) . The lower postprandial glycaemic response is likely due to partial glucose replacement by fructose, which does not contribute substantially to blood glucose and may even stimulate hepatic glucose uptake (51) .…”

Section: Discussionmentioning

confidence: 99%

Dried fruit consumption and cardiometabolic health: a randomised crossover trial

2020

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Fruit intake is associated with lower risk of cardiometabolic diseases. However, effects of dried fruits on cardiometabolic health are not well researched. We investigated the effect of daily dried fruit consumption compared with a carbohydrate-rich snack on cardiometabolic disease risk factors in adults with increased cardiometabolic risk. A two-period randomised crossover trial was conducted in adults (n 55) with elevated BMI and at least one additional risk factor for cardiometabolic disease to compare the effects of consuming 3/4 cup/d mixed dried fruits (plums, figs, dates and raisins) or an energy- and carbohydrate-matched control snack for 4 weeks. The primary outcome was LDL-cholesterol; secondary outcomes included other lipids and lipoproteins, glucose and insulin, C-reactive protein, blood pressure and vascular stiffness. Linear mixed models were used for data analysis. Lipid and lipoprotein concentrations did not differ between conditions; however, dried fruit increased LDL-cholesterol (0·10 mmol/l, 95 % CI 0·01, 0·20) compared with baseline. Compared with the control, dried fruit increased mean fasting glucose (0·08 mmol/l, 95 % CI 0·005, 0·16; P = 0·038). Vascular outcomes, fasting insulin and C-reactive protein did not differ between conditions. Mean weight changes did not differ (P = 0·55) but tended to increase after both conditions (dried fruit 0·3 kg, 95 % CI –0·09, 0·65; control 0·4 kg, 95 % CI 0·01, 0·75). Thus, short-term daily consumption of a large portion of mixed dried plums, figs, dates and raisins, without structured dietary guidance, did not improve cardiometabolic risk factors, compared with carbohydrate-rich snacks, in adults with increased baseline cardiometabolic risk.

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A Study of Glycemic Response to Corinthian Raisins in Healthy Subjects and in Type 2 Diabetes Mellitus Patients

Cited by 31 publications

References 16 publications

Nuts and Dried Fruits: An Update of Their Beneficial Effects on Type 2 Diabetes

Nuts and Dried Fruits: An Update of Their Beneficial Effects on Type 2 Diabetes

Effect of dried fruit on postprandial glycemia: a randomized acute-feeding trial

Dried fruit consumption and cardiometabolic health: a randomised crossover trial

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