A study of gastric secretion and blood flow in the anaesthetized dog

Gastric secretion in relation to mucosal blood flow studied by a clearance technic.

“…There are, however, other reports that present evidence against such a relationship, namely that known secretory stimuli did not increase gastric blood flow and known inhibitors of secretion failed to decrease blood flow to the stomach (7)(8)(9)(10)(11). In four of these reports (7)(8)(9)(10) anesthetized and even hypotensive animals were used, which may account for some of the discrepancies among these papers: histamine was observed to increase (11), to decrease (8), and not to alter gastric blood flow (7,10); epinephrine was found to increase (10,11) and to decrease (7,8) Our results strongly support a positive relationship between gastric secretion and blood flow. In a large number of experiments with seven different drugs that affect gastric secretion, we consistently observed this relationship: as gastric secretion changed, gastric mucosal blood flow (as estimated by clearance) changed correspondingly.…”

“…There is a considerable body of evidence suggesting that secretion and blood flow in the stomach vary together (1)(2)(3)(4)(5)(6) and an equally impressive array of studies that speaks against such a relationship (7)(8)(9)(10)(11). In attempting to evaluate a possible relationship between gastric blood flow and secretion we are confronted with problems that are basically methodological (12).…”

Fluid Transfer in the Everted Human Gallbladder *

“…Norepinephrine increased secretion and permeability of the submaxillary glands of the cat (25) but inhibited gastric secretion in dogs (26,27).…”

“…Of the 47 gallbladders studied, 27 (Figure 1). Thus, fluid movement rather than the weighing procedure per se was responsible for the observed weight changes, and in the everted gallbladder, this weight gain represented movement of fluid from mucosal to serosal surface.…”

Proceedings of the Physiological Society, 17‐18 March 1967, University College Meeting: Communications

“…During all recordings the eyes, though intact, were in complete darkness, and no bursts of activity could be recorded from the electrode in the optic chiasma. PROCEEDINGS OF THE venous outflow measured, by methods previously described (Cumming et al 1963). Simultaneous recordings of blood flow and secretions were made in seven experiments.…”