A study of four cases of extra‐orbital giant cell angiofibroma with documentation of some unusual features

Thomas, Rebecca; Banerjee, Subrata; Eyden, Brian P; Shanks, J H; Bisset, D.L.; Hunt, Roger; Byers, Richard; Oogarah, P; Harris, Martin

doi:10.1046/j.1365-2559.2001.01227.x

Cited by 33 publications

(27 citation statements)

References 14 publications

(22 reference statements)

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“…Mitoses are infrequent and necrosis is not common in SFT. Some histological variants have been described as giant cell SFT fibroma and fat forming SFT [15,16]. Immunohistochemically SFT commonly expresses CD34, CD99 and bcl-2, epithelial membrane antigen (EMA), and smooth muscle actin (SMA) may occasionally be expressed.…”

Section: Resultsmentioning

confidence: 99%

Solitary fibrous tumor of the thigh with epithelioid features: a case report

et al. 2007

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Background: Extrapleural Solitary Fibrous tumors (SFTs) have been increasingly reported. The retroperitoneum, deep soft tissues of proximal extremities, abdominal cavity, trunk, head and neck are the most common extraserosal locations reported. Microscopically they show a wide range of morphological features, and so the differential diagnosis is extensive. Immunohistochemically, they commonly express CD34, vimentin, bcl-2 and CD99. Epithelial membrane antigen (EMA) and smooth muscle actin (SMA) may occasionally be expressed. Epithelioid morphology in extrapleural SFT has only very occasionally been described (five cases reported), some of them with biphasic pattern and others with malignant characteristics.

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Section: Resultsmentioning

confidence: 99%

Solitary fibrous tumor of the thigh with epithelioid features: a case report

et al. 2007

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“…5 GCA usually presents clinically as a slowly growing mass which sometimes can be painful. 13 CT scan and MRI help to detect the exact localization of the lesion, assessment of its extent and resectability. Grossly, giant cell angiofibromas are well circumscribed, they may be variably encapsulated, they are often a small lesion approximately 3 cm average size, however, softtissue lesions tend to be larger than those in orbitalregion, sometimes reaching up to 10 cm.…”

Section: Discussionmentioning

confidence: 99%

“…Grossly, giant cell angiofibromas are well circumscribed, they may be variably encapsulated, they are often a small lesion approximately 3 cm average size, however, softtissue lesions tend to be larger than those in orbitalregion, sometimes reaching up to 10 cm. 13 Upon cut section of these tumor, hemorrhagic and/or cystic changes may be observed. 14 Microscopically, these tumors are well circumscribed, patternless lesions composed of bland looking round to spindle-shaped cells with pale, indistinct cytoplasm set in a variably collagenous or myxoid matrix containing numerous small blood vessels (often with hyalinized vessel walls), irregularly-shaped pseudovascular spaces lined by mononuclear and multinucleate tumor cells; multinucleate giant cells are often floret type, present even in the solidly cellular areas.…”

Section: Discussionmentioning

confidence: 99%

Giant Cell Angiofibroma Scalp: A Rare Neoplasm

Jain¹,

Qadri²,

Afroz³

et al. 2015

International Journal of Head and Neck Surgery

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Giant cell angiofibroma (GCA) is a rare benign pathologic entity that shows a predilection for the mesenchymal tissue of the orbit and head and neck region. It is a highly vascular, wellcircumscribed benign soft-tissue neoplasm that may simulate a malignant or aggressive process. GCA usually presents as a painful mass that grows slowly or remains stable in size over many years. The incidence of extraorbital GCA is very rare, with only two cases of GCA of scalp reported in the literature. The GCA is characterized by a patternless spindle cell proliferation containing pseudovascular spaces, floret-like multinucleated giant cells and a richly vascularized stroma showing hyalinization or myxoid change. CD34 immunoreactivity remains an important immunohistochemical finding of potential diagnostic value. Surgical excision is often curative. We report a case of a 42 years old male with the primary complaint of a painful solitary nodule arising on the occipital region of the scalp. Complete tumor removal through surgical resection was achieved, and diagnosis of Giant cell angiofibroma was rendered on the histopathological and immunohistochemical examination. The postoperative period was uneventful.

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“…Since the original report, approximately 20 new extraorbital cases have been reported in the literature. Extraorbital GCA has been reported in patients ranging in age from 18 to 81 years, without apparent sex predilection 1,7 .…”

Section: Discussionmentioning

confidence: 99%