A study of factors contributing to the development of osteoradionecrosis of the jaws

Kluth, Edwin V.; Jain, Pushpa R.; Stuchell, Robert N.; Frich, John C.

doi:10.1016/0022-3913(88)90015-7

Cited by 129 publications

(75 citation statements)

References 11 publications

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“…This is similar to the pattern of osteoradionecrosis, of which the mandible is also more often affected. This observation had been explained by the more critical blood perfusion of the mandible compared with the maxilla 25 and the antiangiogenetic effect of the bisphosphonates. 26 In 2 of the patients, a previous tooth extraction shortly preceded the onset of BP-ONJ, a phenomenon that has been described as a risk factor several times.…”

Section: Discussionmentioning

confidence: 99%

Incidence of bisphosphonate‐associated osteonecrosis of the jaws in breast cancer patients

Walter

Al‐Nawas

Bois

et al. 2009

Cancer

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BACKGROUND:Bisphosphonate‐associated osteonecrosis of the jaws (BP‐ONJ) is a relatively new disease. The aim of this study was to evaluate the prevalence of BP‐ONJ in breast cancer patients with osseous metastasis and bisphosphonate therapy.METHODS:A retrospective study was conducted in a EUSOMA accredited breast unit in Germany. All patients treated from January of 2000 to March of 2006 with metastatic breast cancer and bisphosphonate therapy were reviewed. All patients were contacted, and missing data were completed through structured interviews with their dentists and physicians (n = 75). Primary outcome was the development of BP‐ONJ and the detection of possible additional trigger factors for the development of BP‐ONJ.RESULTS:A total of 117 patients with breast cancer fulfilled the inclusion criteria, and data for 75 still living patients were included. Of these 75, 4 patients developed a BP‐ONJ, resulting in a prevalence of 5.3%: 3 patients received zoledronate only; 1 patient had first pamidronate followed by zoledronate and ibandronate. A tooth extraction could be identified as an additional trigger factor for 2 patients.CONCLUSIONS:With a prevalence of 5.3%, BP‐ONJ in breast cancer patients has become a relevant disease that should be discussed with patients for whom bisphosphonates have been recommended. Appropriate dental care before bisphosphonate therapy commences has been advised to reduce the occurrence of BP‐ONJ. Cancer 2009. © 2009 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Incidence of bisphosphonate‐associated osteonecrosis of the jaws in breast cancer patients

Walter

Al‐Nawas

Bois

et al. 2009

Cancer

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“…However, many etiologic factors of ORN have been reported in the Conservative treatment of osteoradionecrosis literature. According to Kluth et al 23 ORN can occur through a combination of factors such as tumor site, extraction site, denture irritation, and/or surgery. Oh et al 11 reported that 43% of ORN cases occurred spontaneously or through unknown causes.…”

Section: Case Reportmentioning

confidence: 99%

Successful in a conservative treatment of osteoradionecrosis of the jaw: a case report and review of literature

Moraes

Thomaz

Silva

et al. 2016

RGO, Rev. Gaúch. Odontol.

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Osteoradionecrosis of jaws is one of the most serious complications of radiation therapy for head and neck malignancies. RESUMOOsteorradionecrose dos maxilares é uma das complicações mais sérias da radioterapia para o tratamento de tumores de cabeça e pescoço. O manejo da osteorradionecrose continua sendo discutido e há poucos relatos de casos descrevendo modalidades de tratamento conservadoras. Este artigo apresenta um caso de osteorradionecrose na mandíbula de um paciente de 58 anos de idade, após a realização de exodontia e explora uma modalidade de tratamento conservador com um follow-up de três anos. Foram combinadas antibioticoterapia e irrigação diária utlizando clorexidina. Após três anos é possível observar a resolução do caso em imagens de tomografia computadorizada de feixe cônico e reconstruções 3D. As imagens evidenciam remodelação óssea após este período de acompanhamento e sem a presença de osso exposto. Pode-se concluir que a terapia proposta resultou em sucesso e o paciente continua em acompanhamento periódico.

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“…Many authors of articles on ORN either failed to mention antibiotics at all, or made only a brief comment about their general application. 1,5,8,11,12,[28][29][30] The purpose of this investigation was to determine prescribing for exodontia and minor oral surgery following radiotherapy by surveying current opinion amongst consultant oral and maxillofacial surgeons.…”

Section: N B R I E Fmentioning

confidence: 99%

A survey of antibiotic prescribing by maxillofacial consultants for dental extractions following radiotherapy to the oral cavity

Kanatas¹,

Rogers

Martín

2002

Br Dent J

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Objectives To analyse the antibiotic prescribing trends for exodontia and minor oral surgery in patients with a history of radiotherapy. Also, to evaluate the use of hyperbaric oxygen as a separate modality in the prevention of osteoradionecrosis. Design A survey of antibiotic prescribing involving the analysis of a questionnaire which included the management of three patients with a history of head and neck malignancy. Method The heads of the departments in each unit in the UK were sent a closed-response questionnaire. Antibiotic prescribing was assessed in three case scenarios. Case one referred to a patient that had surgery alone as part of the management of head and neck cancer, who needed the surgical removal of second molar roots. Case two referred to a patient that had surgery and adjuvant radiotherapy as part of the management of head and neck cancer, and needed the same procedure as in case one. Case three included a patient with a history of surgery and adjuvant radiotherapy, who required the extraction of three mobile and periodontally-involved lower incisors. Consultants were also asked about the use of hyperbaric oxygen in the patients who had radiotherapy as part of their treatment strategy. Results A total of 109 questionnaires were sent to all the Maxillofacial Units in the UK. The response rate was 73%. In patients with a history of radical surgery alone for the management of head and neck cancer, 20% of the surgeons advocated pre-operative antibiotics for the surgical removal of lower posterior teeth. In contrast, in the patient with a history of adjuvant radiotherapy 86% supported pre-operative antimicrobial use for the surgical removal of the same teeth. In the extraction of mobile and periodontally involved lower incisors in the previously irradiated patient, 63% of the clinicians supported pre-extraction antibiotics. Postoperative antibiotics were advocated in 52% in the first case, 89% in the second case and 71% in the third case. 34% of the clinicians advocated hyperbaric oxygen for surgical removal of posterior teeth and 15% for the extraction of mobile anterior teeth.

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A study of factors contributing to the development of osteoradionecrosis of the jaws

Cited by 129 publications

References 11 publications

Incidence of bisphosphonate‐associated osteonecrosis of the jaws in breast cancer patients

Incidence of bisphosphonate‐associated osteonecrosis of the jaws in breast cancer patients

Successful in a conservative treatment of osteoradionecrosis of the jaw: a case report and review of literature

A survey of antibiotic prescribing by maxillofacial consultants for dental extractions following radiotherapy to the oral cavity

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