A Study of Epidemiologic and Recurrence Factors of Oral Cancer

Wang, Wei; Han, Sheng; Zhanpeng, Yao; Li, Xin; Huang, Ping; Zhang, Ming; Yan, Chen‐Hua; He, Jianjun

doi:10.1016/j.joms.2011.09.040

Cited by 25 publications

(29 citation statements)

References 21 publications

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“…Otherwise, the remainder of our results are comparable to past research findings. For example, smoking has been consistently shown to be disproportionately higher in rural populations . We confirmed this observation in our study cohort, where we found that patients living in a RA were more likely to have a smoking history than patients residing in non‐RA areas.…”

Section: Discussionmentioning

confidence: 51%

“…Using data from the British Columbia Cancer Agency and its provincial cancer registry, we evaluated the impact of urban and rural place of residence on outcomes of non‐nasopharyngeal HNC in a real‐world setting. This study represents one of the largest retrospective population‐based cohort analysis of HNC patients treated in British Columbia, Canada over a 10‐year timeframe, and improves on previously published work from other groups that have largely focused on a single HNC etiology across only a few specific institutions …”

Section: Introductionmentioning

confidence: 99%

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Urban and rural differences in outcomes of head and neck cancer

et al. 2017

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Urban and rural differences in outcomes of head and neck cancer

et al. 2017

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“…Prognosis is poor for most untreated patients with head and neck cancer (36) and these patients are likely to have a high chance of recurrence or distant metastases. There is limited evidence that smoking may increase risk of recurrence or distant metastases (37)(38)(39), and this could explain our findings. However, large, robust, population-based studies are required to better clarify the magnitude of the relationships between smoking and recurrence and distant metastases and how this evolves over time from diagnosis, before firmer conclusions can be reached Patients with head and neck cancer have a 36% cumulative risk of being diagnosed with a second primary cancer over 20 years, and the most common sites are the head and neck and lung (40).…”

Section: Smoking Recurrence and Second Primariesmentioning

confidence: 60%

Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study

Sharp

McDevitt

Carsin

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Some studies suggest smoking may result in poorer clinical outcomes in head and neck cancer, but the evidence is heterogeneous and some of it is poor quality. In a large, population-based, study we investigated: (i) whether smoking at diagnosis is an independent prognostic factor for cancer-specific survival in head and neck cancer; and (ii) whether the association varies by site and treatment.Methods: Head and neck cancers (ICD10 C01-C14, and C30-32) diagnosed from 1994 to 2009 were abstracted from the National Cancer Registry Ireland, and classified by smoking status at diagnosis. Follow-up was for 5 years or until December 31, 2010. Multivariate Cox proportional hazards models were used to compare cancerspecific death rates in current, ex-, and never smokers. Subgroup analyses by site and treatment were conducted.Results: In total, 5,652 head and neck cancers were included. At diagnosis, 24% were never smokers, 20% exsmokers, and 56% current smokers. Compared with never smokers, current smokers had a significantly raised death rate from cancer [multivariate HR, 1.36; 95% confidence interval (CI), 1.21-1.53]. The association was similar after restriction to squamous cell tumors. A significantly increased cancer-related death rate was seen for current smokers with oral cavity, pharyngeal, and laryngeal cancers. The association was stronger in surgically treated patients [HR, 1.49; 95% CI, 1.25-1.79; P(interaction) ¼ 0.01]. Neither radiotherapy nor chemotherapy modified the effect of smoking.Conclusions: Patients with head and neck cancer who smoke at diagnosis have a significantly increased cancer death rate.Impact: Greater efforts are needed to encourage and support smoking cessation in those at risk of, and diagnosed with, head and neck cancer. Cancer Epidemiol Biomarkers Prev; 23(11); 2579-90. Ó2014 AACR.

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“…Recurrence can be local, regional, locoregional or second primaries. Recurrence rates vary between 25-40% after a follow-up period of 2-4 years (Hakeem et al, 2012;Priya et al, 2012;Wang et al, 2012). Most recurrences are local (Hakeem et al, 2012;Priya et al, 2012).…”

Section: Recurrencementioning

confidence: 99%

“…A considerable proportion of cases (34%) in Japan presented with second primaries (Shiga et al, 2011). The clinicopathological factors that influence the treatment outcome and likelihood of recurrence are use of tobacco, advanced T stage or stage III-IV disease at diagnosis, including local regional nodal involvement, positive resection margins or the resection margins being very close to the tumour and thickness of tumour ≥7mm (Battoo et al, 2012;Hakeem et al, 2012;Priya et al, 2012;Wang et al, 2012). Patients who are pathologically negative for local regional nodal involvement could present with regional metastasis later due to occult metastasis (Liu et al, 2010).…”

Section: Recurrencementioning

confidence: 99%

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rao¹,

Mejía²,

Roberts‐Thomson³

et al. 2013

Asian Pacific Journal of Cancer Prevention

396

256

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The prevalence of oral cancers (OC) is high in Asian countries, especially in South and Southeast Asia. Asian distinct cultural practices such as betel-quid chewing, and varying patterns of tobacco and alcohol use are important risk factors that predispose to cancer of the oral cavity. The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012. A literature search for this review was conducted on Medline for articles on OC from Asian countries. Some of the articles were also hand searched using Google. High incidence rates were reported from developing nations like India, Pakistan, Bangladesh, Taiwan and Sri Lanka. While an increasing trend has been observed in Pakistan, Taiwan and Thailand, a decreasing trend is seen in Philippines and Sri Lanka. The mean age of occurrence of cancer in different parts of oral cavity is usually between 51-55 years in most countries. The tongue is the leading site among oral cancers in India. The next most common sites in Asian countries include the buccal mucosa and gingiva. The 5 year survival rate has been low for OC, despite improvements in diagnosis and treatment. Tobacco chewing, smoking and alcohol are the main reasons for the increasing incidence rates. Low socioeconomic status and diet low in nutritional value lacking vegetables and fruits contribute towards the risk. In addition, viral infections, such as HPV and poor oral hygiene, are other important risk factors. Hence, it is important to control OC by screening for early diagnosis and controlling tobacco and alcohol use. It is also necessary to have cancer surveillance at the national-level to collect and utilise data for cancer prevention and control programs.

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A Study of Epidemiologic and Recurrence Factors of Oral Cancer

Cited by 25 publications

References 21 publications

Urban and rural differences in outcomes of head and neck cancer

Urban and rural differences in outcomes of head and neck cancer

Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

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