A Study of Elastic Arteries in Irradiated Mice of Different Ages.

Smith, Charles Saumarez; Loewenthal, Lois A.

doi:10.3181/00379727-75-18369

Cited by 38 publications

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“…Radiation-induced injury either causing or accelerating atherosclerotic changes in the carotid arteries has been well-documented in both experimental animal and human subjects. [8][9][10][11][12][13][14][15][16][17] Thus the possibility of post-irradiation intracranial arterial stenosis due to atherosclerosis is a particular concern. Intracranial atherosclerotic stenosis is a significant risk factor for stroke and is postulated to cause approximately 15% of all ischaemic events.…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy for Nasopharyngeal Carcinoma as a Risk Factor for Extracranial Carotid Stenosis. Is It Also a Risk Factor for Intracranial Arteries? A Retrospective Case-control Study

Chu¹,

Tsang²,

Wong³

et al. 2015

Hong Kong J Radiol

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Objective: Carotid duplex ultrasound has revealed that radiotherapy is associated with stenosis of the extracranial carotid arteries in patients with nasopharyngeal carcinoma (NPC). The objective of the study was to determine the relationship between intracranial and extracranial arterial stenosis and radiation therapy using computed tomographic angiography (CTA) in patients with NPC and a history of symptomatic cerebral ischaemia. Methods: This was a retrospective case-control study conducted in Pok Oi Hospital, Hong Kong. All consecutive CTA scans of the head and neck from January 2008 to December 2009 in patients with a history of transient ischaemic attack or ischaemic stroke were included. Intracranial arterial (including intracranial internal carotid artery, M1 segment of middle cerebral artery, and intracranial vertebral artery) and extracranial arterial stenosis was defined as a diameter reduction of ≥50%. Patient demographics, history of radiotherapy for NPC, smoking history, medical history of diabetes mellitus, hypertension, and hyperlipidaemia were recorded. Results: A total of 152 patients (105 men and 47 women; mean [standard deviation] age, 64.9 [11.6] years) were enroled. Of them, 19 (12.5%) had a history of NPC and treatment by radiotherapy; 133 (87.5%) patients did not receive any head and neck radiotherapy. A statistically significantly increased risk of common carotid artery stenosis (p < 0.001; adjusted odds ratio = 34.510) and extracranial arterial stenosis (p = 0.001; adjusted odds ratio = 6.607) was observed in patients with NPC treated with radiotherapy compared with those without irradiation. Radiotherapy did not increase the risk of intracranial arterial stenosis (10/19 [52.6%] vs. 75/133 [56.4%]; p = 0.710). Conclusion: Radiotherapy for NPC is associated with an increased risk for stenosis of the extracranial arteries, particularly the common carotid artery. Radiotherapy for NPC was not shown to increase the risk of intracranial artery stenosis based on CTA findings in patients with symptomatic cerebral ischaemia.

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Section: Introductionmentioning

confidence: 99%

Radiotherapy for Nasopharyngeal Carcinoma as a Risk Factor for Extracranial Carotid Stenosis. Is It Also a Risk Factor for Intracranial Arteries? A Retrospective Case-control Study

Chu¹,

Tsang²,

Wong³

et al. 2015

Hong Kong J Radiol

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Carotid Artery Occlusive Disease Following External Cervical Irradiation

Levinson¹,

Close²,

Ehrenfeld³

et al. 1973

Arch Surg

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Delayed cerebrovascular consequences of therapeutic radiation.A clinicopathologic study of a stroke associated with radiation-related carotid arteriopathy

Conomy

Kellermeyer

1975

Cancer

144

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A young woman, successfully treated for Hodgkin's disease with radiation and MOPP chemotherapy, incurred a devastatiq stroke months after radiation therapy to the neck and other areas. There was no premonitory clinical history of cerebrovascular attacks. Autopsy showed unilateral thrombotic occlusion of the internal carotid artery unassociated with neoplastic or fibrotic annular constriction of the vessel. There was medial thickening and fibroblastic proliferation within the carotid artery. Areas of focal elastic membrane degeneration involved the cervical portions of the carotid. Thrombus was organized to the damaged vessel wall and was propagated into the intracranial vessels. Aneurysm formation and arterial hemorrhages were absent. These vascular changes occurred in an area of extensive radiation (7200 rads). Pathoanatomical studies in this patient indicate that radiation-induced vascular changes were associated with a "delayed" stroke.

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A Study of Elastic Arteries in Irradiated Mice of Different Ages.

Cited by 38 publications

References 0 publications

Radiotherapy for Nasopharyngeal Carcinoma as a Risk Factor for Extracranial Carotid Stenosis. Is It Also a Risk Factor for Intracranial Arteries? A Retrospective Case-control Study

Radiotherapy for Nasopharyngeal Carcinoma as a Risk Factor for Extracranial Carotid Stenosis. Is It Also a Risk Factor for Intracranial Arteries? A Retrospective Case-control Study

Carotid Artery Occlusive Disease Following External Cervical Irradiation

Delayed cerebrovascular consequences of therapeutic radiation.A clinicopathologic study of a stroke associated with radiation-related carotid arteriopathy

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