A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype

Abstract

These data suggest that the presence of Dsg1 antibodies is predictive of a potentially more severe disease and that genetic factors may determine the Dsg antibody profile.

Pemphigus Vulgaris: An Insight on Conventional and Emerging Treatment Modalities

“…Pesticide exposure 9. Pregnant females 10 The demonstration by Beutner and Jordan of serum antibodies directed against the intercellular substance of stratified squamous epithelium was the first in a series of findings that suggested that PV may be an auto immune disease. 11 Pemphigus vulgaris is an autoimmune disorder in which there is deposition of mainly IgG class antibodies intracellularly, as well as damage to desmosomes by antibodies directed against the extracellular domains of cadherin-type epithelial cell adhesion molecules, particularly desmoglein 3.…”

Pemfigusta Desmoglein Antikor Serum Düzeyleri ile Direkt İmmünofloresan Bulgularının Hastalığın Klinik Aktivitesi ile İlişkisi

“…Pemfigus vulgariste anti-dsg 3 antikorlar› için tan›sal hassasiyet de¤iflik çal›flmalarda %85-100 olarak bildirilmektedir 7,[14][15][16] . Anti-dsg 1 antikorlar› ise pemfigus vulgarisli hastalarda de¤iflik oranlarda (%36-95 aras›nda) pozitif bulunmufltur 7,[15][16][17][18][19] . Bu çal›flmada klinik ve histopatolojik olarak pemfigus vulgaris tan›s› alm›fl olan 23 hastan›n hepsinde (%100) anti-dsg 3 antikorlar› pozitif saptan›rken; anti-dsg 1 pozitifli¤i ‹talya ve ‹ran'dan bildirilen oranlara yak›n (%73,9) bulunmufltur.…”

“…Bu çal›flmada klinik ve histopatolojik olarak pemfigus vulgaris tan›s› alm›fl olan 23 hastan›n hepsinde (%100) anti-dsg 3 antikorlar› pozitif saptan›rken; anti-dsg 1 pozitifli¤i ‹talya ve ‹ran'dan bildirilen oranlara yak›n (%73,9) bulunmufltur. Farkl› çal›flmalarda anti-dsg 1 otoantikorlar›nda de¤iflik s›kl›kta pozitiflik saptanmas› klinik fenotiplerde görü-lebilen ›rksal farkl›l›klara ba¤lanmaktad›r 16,18 . Ülkemizde Akdeniz bölgesi'nde yap›lan bir çal›flmada olgular›n %87'sinde, ‹ran'-da ise %69,9 oran›nda mukokütanöz hastal›k bildirilmifltir 16,20 .…”

Diagnosis and Management of Desquamative Gingivitis

“…In well developed disease almost all PV patients have circulating autoantibodies to Dsg3 Daneshpazhooh et al, 2007;Harman et al, 2000). More than 50% of PV patients also have Dsg 1 autoantibodies, the primary antigen of pemphigus foliaceus Daneshpazhooh et al, 2007;Harman et al, 2000). In some PV patients, the Dsg autoantibody profile correlates with the clinical manifestations (Daneshpazhooh et al, 2007;Endo et al, 2008c).…”

“…The main target antigen of PV is desmoglein (Dsg) 3, a constituent of the extracellular region of desmosomes on keratinocytes (Amagai, 1999). In well developed disease almost all PV patients have circulating autoantibodies to Dsg3 Daneshpazhooh et al, 2007;Harman et al, 2000). More than 50% of PV patients also have Dsg 1 autoantibodies, the primary antigen of pemphigus foliaceus Daneshpazhooh et al, 2007;Harman et al, 2000).…”