A Study of Correlation of High Sensitivity C - Reactive Protein With Various Components of Metabolic Syndrome at a Tertiary Centre

Abstract

BACKGROUND:The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, which includes abdominal obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Recent evidence implicates inflammation in the development of insulin resistance and MetS. Evidence has emerged demonstrating that high concentrations of high-sensitive C-reactive protein (hsCRP) are associated with MetS and may predict diabetes and cardiovascular events, independent of traditional risk factors. It has also been suggested that hsCRP may be included in the criteria for MetS. OBJECTIVES OF THE STUDY: To study the significance of high sensitivity C-reactive protein as a biochemical marker in metabolic syndrome. To correlate high sensitivity C-reactive protein titres with fasting plasma glucose, body mass index, blood pressure, waist circumference, triglyceride and high density cholesterol levels. MATERIALS AND METHODS: 50 cases and 50 controls were taken into the study. Cases were selected according to new IDF criteria. RESULTS: In the present study, there were 23 males & 27 females in each study group with mean Age distribution of 48.32±14.2 among cases and 48.12±14.1 among controls. Mean BMI in our study was 30.48±1.76 among cases and 23.42±1.52 among controls, with all cases meeting criteria for metabolic syndrome according to new IDF criteria. In our study 84% of cases were hypertensives, 10% of controls had systolic Blood. Pressure >130mmHg. 82% of cases were known diabetics on treatment. 82.6% of cases (Males) had HDL <40. All cases (females) had HDL<50. All cases had hsCRP >3, 88% of controls had hsCRP <3. Age, waist, circumference, BMI, SBP, DBP, FBS, TG levels correlated positively whereas HDL levels correlated negatively with hsCRP levels. CONCLUSIONS: There is a positive association between increasing age and the increase in prevalence of metabolic syndrome. Waist circumference and BMI correlated positively with hsCRP values, implying that obesity plays an important role in inflammation and pathogenesis of metabolic syndrome. There is a positive correlation between individual components of metabolic syndrome with increasing hsCRP titres. hsCRP titres increased significantly with increasing values of FBS, SBP, DBP, TG levels. hsCRP titres increased significantly with decreasing values of HDL. KEYWORDS: Metabolic Syndrome, high sensitivity C reactive protein, Waist circumference, Obesity, Diabetes, Hypertension, Dyslipidemia. INTRODUCTION:The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, which includes. abdominal obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. 1 Recently, several lines of evidence implicate inflammation in the development of insulin resistance and MetS. 2 Furthermore, abundant evidence has emerged demonstrating that high concentrations of high-sensitive C-reactive protein (hsCRP) are associated with MetS and may predict diabetes and cardiovascular events, independent of traditional risk factors.