A study of correlation between molecular subtypes of breast cancer and site of metastasis

Chauhan, Akashdeep Singh; Sachan, Praveendra Kumar; Chauhan, Neena

doi:10.4103/2278-0513.197864

Cited by 1 publication

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“…A number of studies have looked at the relationship between receptor status and metastatic site. 8,14-16 Most studies reported that bone was the most common site of breast cancer metastasis. They also found that bone metastases were associated with ER-positive and/or PR-positive, HER2-negative and with ER-positive/HER2-positive tumors; that HER2-positive tumors were strongly associated with liver metastases; and that triple-negative tumors were associated with brain metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…7 The development of metastatic disease is often unpredictable but has been associated with the initial stage at diagnosis and with other tumor characteristics, including receptor status. 8 All subtypes of breast cancer on the basis of hormonal and human epidermal growth factor receptor 2 (HER2) receptor status have the potential to become metastatic. 7 Other risk factors for metastases include age, nodal status, tumor grade, and size.…”

Section: Introductionmentioning

confidence: 99%

“…10-13 High-income countries have documented metastatic disease patterns in relation to receptor status and molecular subtype of breast cancer. 8,14-16 No studies from sub-Saharan Africa have specifically described patterns of metastatic breast cancer with patient and tumor characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Metastatic Breast Cancer in Kenya: Presentation, Pathologic Characteristics, and Patterns—Findings From a Tertiary Cancer Center

Ekpe

Shaikh

Shah

et al. 2019

JGO

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PURPOSE The purpose of this research was to describe the sociodemographic and clinical characteristics of Kenyan women with metastatic breast cancer diagnosed and treated at Aga Khan University Hospital in Nairobi, Kenya from 2012 to 2018. PATIENTS AND METHODS We reviewed charts of Kenyan women with metastatic breast cancer and analyzed sociodemographic data, breast cancer risk factors, and tumor characteristics associated with stage at diagnosis, receptor status (ie, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 [HER2]), and site of metastasis using χ2, analysis of variance, two-sample t tests, and logistic regressions. RESULTS A total of 125 cases with complete medical records were included in the analysis. Forty women (32%) had metastases at diagnosis. Of the others, those diagnosed in stage III developed metastases sooner than those diagnosed in stage II ( P < .001). Fifty-eight percent of patients had metastases to bone, 14% to brain, 57% to lungs, and 50% to liver. Seventy-four percent of patients presented with more than one metastatic site. Metastases to bone were associated with greater age at diagnosis ( P = .02) and higher parity ( P = .04), and metastases to the brain were associated with early menopause ( P = .04), lower parity ( P = .04), and lack of breastfeeding ( P = .01). Patients whose tumors were triple negative (estrogen receptor-negative, progesterone receptor-negative, and HER2 negative) were more likely to develop brain metastases ( P = .01), and those whose tumors were HER2 positive were more likely to develop liver metastases ( P = .04). CONCLUSION Although our data on patterns of metastases and pathologic subtypes are similar to those in published literature, some unique findings concerning hormonal risk factors of women with metastatic breast cancer and specific metastatic sites need additional exploration in larger patient populations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%