A Study of Corneal Biomechanics in Delayed-Onset Mustard Gas Keratopathy Compared to Cases With Corneal Scarring and Normal Corneas

Jadidi, Khosrow; Mohazzab-Torabi, Saman; Pirhadi, Shiva; Naderi, Mostafa; Yekta, Abbasali; Sardari, Sara; Khabazkhoob, Mehdi

doi:10.1097/icl.0000000000000536

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…We know that mustard gas damages the cornea, and to the best of our knowledge, up until the present, some studies have been evaluated the structure of cornea with DMGK. Corneal biomechanical parameters were measured in two studies by Jadidi et al [15] and Naderi et al [22]. As well as, clinical and confocal microscopic findings have been reported in these veterans [12,16,[23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…Which, in this keratitis, recurrent infections cause fibrosis and neovascularization and this condition eventually leads to corneal scarring and opacity [17]. This study followed a study conducted by Jadidi et al [15]. That, they evaluated the corneal biomechanical parameters in eyes with corneal scarring due to herpes simplex and eyes with severe DMGK using Corvis ST.…”

Section: Introductionmentioning

confidence: 99%

“…There are about 100,000 individuals who have been chemically injured in Iran, and approximately 0.5% of them suffer from DMGK [10,11]. Although there have been several studies of DMGK in terms of signs and symptoms, surgical procedures, pharmacology, and biomechanical parameters [12,15], the pathophysiology of progressive ocular changes in this keratopathy is not well known [16]. To reach a better knowledge of corneal structure in patients with severe DMGK, we evaluated the densitometric values and also topographic patterns of the cornea using the Pentacam high resolution (HR) (OCULUS, Wetzlar, Germany) in these rare patients.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of corneal topographic patterns and densitometric parameters in patients with severe delayed-onset mustard gas keratopathy and patients suffered from corneal scarring

Bagheri¹,

Jadidi²

2022

J Clin Images Med Case Rep

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Purpose: This study was performed to evaluate the densitometric values and the type of corneal topographic pattern extracted from Pentacam HR (OCULUS, Wetzlar, Germany) in two groups of severe delayed-onset mustard gas keratopathy (DMGK) and old herpes simplex corneal scarring. Materials and methods: Twenty eyes of each group were enrolled to the study and were examined using the Pentacam HR. Total corneal densitometry was measured over a 12 mm diameter area, divided by annular concentric regions and depths. Also, the corneal topographic pattern from the axial curvature map of the anterior corneal surface was determined in all patients. Results: The most common observed patterns in severe DMGK and old corneal scarring were superior steepening and irregular pattern, respectively. Densitometry measurement in 10 to 12 mm in diameter in DMGK was significantly higher than old corneal scarring. There were not any significant differences in other densitometry values between the groups. Conclusion: It seems that clinical evaluation of corneal structure using Pentacam can improve our knowledge about this rare mustard gas keratopathy. Keywords: Delayed-onset mustard gas keratopathy; Corneal scarring; Pentacam HR; Densitometry; Corneal pattern.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of corneal topographic patterns and densitometric parameters in patients with severe delayed-onset mustard gas keratopathy and patients suffered from corneal scarring

Bagheri¹,

Jadidi²

2022

J Clin Images Med Case Rep

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“…Corneal biomechanical properties in MGK indicate reduced corneal stiffness. 42 Corneal melt secondary to limbal infiltration has a similar appearance to Mooren ulcer 22 (Fig. 2).…”

Section: Delayed-onset Ocular Manifestationmentioning

confidence: 93%

Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management

Soleimani

Momenaei

Baradaran‐Rafii

et al. 2022

Cornea

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Purpose: Mustard gas (MG) is a potent blistering and alkylating agent that has been used for military and terrorism purposes. Ocular surface injuries are common after exposure to MG. This review provides an update on the pathophysiology, ocular surface complications, and treatment options for MG-related ocular injuries.Methods: Required information was obtained by reviewing various databases such as Cochrane Library, Google Scholar, and PubMed until March 2022. Data were collected by using keywords: "mustard gas" OR "sulfur mustard" AND "eye" OR "cornea" OR "ocular complication" OR "keratitis" OR "keratopathy" OR "limbal stem cell deficiency" OR "dry eye."Results: Chronic intracellular toxicity, inflammation, and ischemia have been shown to play an essential role in the pathogenesis of MG injury. Ocular surface injuries can have acute, chronic, and most distinctly a delayed-onset presentation leading to various degrees of limbal stem cell deficiency. To date, no treatment has been agreed on as the standard treatment for chronic/delayed-onset MG keratopathy. Based on the authors' experience, we propose a management algorithm for MG-related ocular surface injuries involving optimization of ocular health, anti-inflammatory therapy, and if needed surgical interventions. The management of chronic and delayedonset presentation remains challenging.Conclusions: MG keratopathy is a unique form of chemical injury which can lead to a range of ocular surface pathologies. Long-term anti-inflammatory therapy even in patients with seemingly mild disease may potentially reduce the likelihood of the development of more severe delayed-onset disease.

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Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure

Sinha

Tripathi

Balne

et al. 2022

Experimental Eye Research

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A Study of Corneal Biomechanics in Delayed-Onset Mustard Gas Keratopathy Compared to Cases With Corneal Scarring and Normal Corneas

Cited by 5 publications

References 16 publications

Assessment of corneal topographic patterns and densitometric parameters in patients with severe delayed-onset mustard gas keratopathy and patients suffered from corneal scarring

Assessment of corneal topographic patterns and densitometric parameters in patients with severe delayed-onset mustard gas keratopathy and patients suffered from corneal scarring

Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management

Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure

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