A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group 
Utility of direct immunofluorescence

Hrabovska, Z; Jautová, J; Hrabovsky, V

doi:10.4149/bll_2017_048

Cited by 8 publications

(12 citation statements)

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Characteristic histopathological findings of PV are acantholysis with rounding up of keratinocytes, and a suprabasilar cleft [111]. The basal keratinocytes remain attached to the basement membrane, and line the blister floor, resulting in a typical tombstone appearance.…”

Section: Diagnostic Algorithm In Patients With Oral Blistersmentioning

confidence: 99%

Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm

et al. 2019

View full text Add to dashboard Cite

Autoimmune bullous diseases are a group of chronic inflammatory disorders caused by autoantibodies targeted against structural proteins of the desmosomal and hemidesmosomal plaques in the skin and mucosa, leading to intra-epithelial or subepithelial blistering. The oral mucosa is frequently affected in these diseases, in particular, in mucous membrane pemphigoid, pemphigus vulgaris, and paraneoplastic pemphigus. The clinical symptoms are heterogeneous and may present with erythema, blisters, erosions, and ulcers localized anywhere on the oral mucosa, and lead to severe complaints for the patients including pain, dysphagia, and foetor. Therefore, a quick and proper diagnosis with adequate treatment is needed. Clinical presentations of autoimmune bullous diseases often overlap and diagnosis cannot be made based on clinical features alone. Immunodiagnostic tests are of great importance in differentiating between the different diseases. Direct immunofluorescence microscopy shows depositions of autoantibodies along the epithelial basement membrane zone in mucous membrane pemphigoid subtypes, or depositions on the epithelial cell surface in pemphigus variants. Additional immunoserological tests are useful to discriminate between the different subtypes of pemphigoid, and are essential to differentiate between pemphigus and paraneoplastic pemphigus. This review gives an overview of the clinical characteristics of oral lesions and the diagnostic procedures in autoimmune blistering diseases, and provides a diagnostic algorithm for daily practice.

show abstract

Section: Diagnostic Algorithm In Patients With Oral Blistersmentioning

confidence: 99%

Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Of the remaining papers and their references, 58 documented at least one case of PE, corresponding to 226 total patients. Eight of the papers reported case‐series for a total 139 patients without providing the individual patient data 7‐14 . Those papers are briefly mentioned but were not included in statistical analyses of the demographic, clinical, and serological data reported below.…”

Section: Resultsmentioning

confidence: 99%

Pemphigus erythematosus: A case series from a tertiary academic center and literature review

et al. 2021

View full text Add to dashboard Cite

Background Pemphigus erythematosus (PE) is a rare autoimmune skin condition with clinical, histopathological, and serological features that show overlap between lupus erythematosus and pemphigus foliaceus. It typically presents with erythematous, scaly plaques and has a female predominance. Methods After Institutional Review Board (IRB) approval, we searched the internal pathology database for “pemphigus erythematosus” in the diagnostic line between 1 January 2000 and 30 July 2020. A comprehensive chart review was performed to collect patient demographics, clinical presentation, and treatment course. We performed a review of the literature and clinical, histopathological, and serological features were collected for comparison to our case series. Results Five patients in the case series and 87 patients in the literature were diagnosed with PE. Clinical, histopathological, and serological features were consistent with what has been reported in the literature, although our cohort demonstrated a younger age at presentation, along with a higher proportion (80%) of Black patients. Of the 25 patients in the literature whose race was reported, only five patients (20%) were reported to be Black. Conclusion This is the first case series of PE that has shown an increased prevalence among middle‐aged Black patients. No specific trend in regards to race was seen in the review of the literature.

show abstract

“…To make a definitive diagnosis of any immunobullous disorder including the pemphigus variants, the clinical, pathologic, and immunologic features all must correlate with the diagnosis of that particular immunobullous disorder. Therefore, studies of PH were excluded if they did not present adequate information of the clinical, pathologic, or immunologic findings . The most common clinical, pathologic, and immunologic features were then considered as potential diagnostic criteria, in order to maintain a high sensitivity and specificity.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, studies of PH were excluded if they did not present adequate information of the clinical, pathologic, or immunologic findings. [35][36][37] The most common clinical, pathologic, and immunologic features were then considered as potential diagnostic criteria, in order to maintain a high sensitivity and specificity. From included studies, we gathered the following patient variables: gender, age at diagnosis, clinical presentation of PH, comorbid conditions, pathologic findings, immunologic findings, treatment, and follow-up course.…”

Section: Methodsmentioning

confidence: 99%

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria

2019

View full text Add to dashboard Cite

Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria. Through a comprehensive review of Medline and PubMed databases, 96 publications and 158 cases were identified. After reviewing the reported characteristics of PH, we suggest the following diagnostic criteria: Clinical: 1) pruritic herpetiform intact blisters with/without erosions; and/or 2) pruritic annular or urticarial erythematous plaques with/without erosions; Pathologic: 1) intraepidermal eosinophils or neutrophils, or both; and/or 2) intraepidermal split with/without acantholysis; Immunologic: 1) direct immunofluorescence showing immunoglobulin G with/without C3 intercellular deposits; and/or 2) indirect immunofluorescence showing immunoglobulin G to epithelial cell surface; and/or 3) detection of serum autoantibodies against desmogleins (1,3) or desmocollins (1,2,3), or both. Diagnosis requires one clinical, one pathologic, and one immunologic feature. We also report three new cases diagnosed at our institution to demonstrate the applicability of the suggested criteria.

show abstract

A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence

Cited by 8 publications

References 9 publications

Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm

Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm

Pemphigus erythematosus: A case series from a tertiary academic center and literature review

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria

Contact Info

Product

Resources

About