A Study of Changes in Serum Concentration of Sodium, Potassium, Chloride and Magnesium in Pre and Post Cisplatin and 5-Flourouracil Chemotherapy in Head and Neck Cancer Patients

Das, Uma; Devi, Bharati; Bhattacharyya, Kailash; Bora, Keshab; Gupta, Pratim

doi:10.21474/ijar01/2684

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“…Besides the effect on survival, there were studies assessing the influence of cisplatin on serum ion concentration and trace elements [ 21 , 22 ]. However, rare studies focus on the effect of TMZ chemotherapy on serum ion concentration in patients with glioma.…”

Section: Introductionmentioning

confidence: 99%

Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma

et al. 2022

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Background Adjuvant temozolomide (TMZ) chemotherapy with standard regimen remarkably improves survival in patients with high-grade glioma (HGG). However, the influence of long-term TMZ chemotherapy on serum ions concentration is unclear. Methods One hundred and thirty-eight patients with HGG were included. Their blood samples were collected for blood biochemistry and routine test. The alteration in serum ions concentration, total protein, albumin, globin, and blood cells counts were used to identify the impact of long-term TMZ chemotherapy. Results Through the comparation of quantitative value of diverse parameters among different chemotherapy cycles, we identified that serum potassium concentration had a downward trend after TMZ administration (1st vs. 6th, p < 0.001; 1st vs. 12th, p < 0.001). Additionally, the correlation analysis showed that platelets was negatively correlated with chemotherapy cycles (r = − 0.649, p = 0.023). The hematological adverse events mainly centered on grade 1 to 2. Conclusion Long-term administration of TMZ may lead to serum ions disturbance. Besides the myelosuppression, we should pay attention to the alteration in serum ions concentration, and give patients proper symptomatic treatment when necessary.

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Section: Introductionmentioning

confidence: 99%