A Study of Calcium Dynamics in Infected Erythrocytes of Nigerian Children with Plasmodium falciparum Malaria

Iwalokun, BA; Olukosi, Yetunde A.; Oduro, K.K.; ., E. Iyamu

doi:10.3923/jms.2007.565.571

J. of Medical Sciences

2007

DOI: 10.3923/jms.2007.565.571

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A Study of Calcium Dynamics in Infected Erythrocytes of Nigerian Children with Plasmodium falciparum Malaria

BA Iwalokun¹,

Yetunde A. Olukosi²,

K.K. Oduro³

et al.

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2021

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“…Hypomagnesemia impairs the release of parathormone by the parathyroid gland and blunt the tissue response to parathormone. 7 This in turn results in hypocalcemia. Many studies found out that hypocalcemia has prognostic value in malaria as it may indicate complicated malaria or heavy parasitemia and its return to normal serum level may indicate clinical recovery and parasite clearance.…”

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confidence: 99%

A study of serum calcium level in cases of malaria in a tertiary care hospital

Parikh¹,

Shah²,

Doctor³

et al. 2021

Int J Adv Med

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Background: Malaria is a tropical disease caused by Plasmodium species, commonly P. falciparum and P. vivax. Carpopedal spasm has been noted in many patients presenting with malarial fever. Most of the patients are later found to have hypocalcaemia. Hypocalcaemia associated with malaria can cause many clinical manifestations, including life threatening conditions such as arrhythmias, convulsions etc.Methods: A cross-sectional study was conducted with the aim to determine the prevalence and clinical profile of hypocalcaemia in different types of malarial fever. 88 patients of malarial fever were studied. Patients were stratified according to the species of plasmodium and into complicated and uncomplicated malaria. Total serum calcium level and QTc interval were analysed in each patient. Data collected were analysed.Results: Prevalence of hypocalcaemia in malaria was found to be 54.45% in our study. Hypocalcaemia was more prevalent in complicated malaria than uncomplicated malaria. Complicated falciparum malaria showed highest prevalence of hypocalcaemia. Status of complexity of malaria was not found to be related to occurrence of hypocalcaemia in any types of malaria. Prevalence of QTc prolongation in malaria was found to be 48.46%. Prevalence of QTc prolongation was found to be more in complicated malaria than uncomplicated malaria. QTc prolongation was most prevalent in complicated falciparum malaria. 83.3% of those with QTc prolongation had hypocalcaemia.Conclusions: Hypocalcemia and QTc prolongation were more prevalent in complicated malaria than in uncomplicated malaria. Both Hypocalcaemia and QTc prolongation were most prevalent in complicated falciparum malaria.

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confidence: 99%

A study of serum calcium level in cases of malaria in a tertiary care hospital

Parikh¹,

Shah²,

Doctor³

et al. 2021

Int J Adv Med

View full text Add to dashboard Cite

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A Study of Calcium Dynamics in Infected Erythrocytes of Nigerian Children with Plasmodium falciparum Malaria

Cited by 1 publication

References 33 publications

A study of serum calcium level in cases of malaria in a tertiary care hospital

A study of serum calcium level in cases of malaria in a tertiary care hospital

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