A study of best positive predictors for sustained virologic response to interferon alpha plus ribavirin therapy in naive chronic hepatitis C patients

Idrees, Muhammad; Riazuddin, Sheikh

doi:10.1186/1471-230x-9-5

Cited by 62 publications

(66 citation statements)

References 19 publications

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“…Due to awareness programs at the public level, sterilized surgical procedures and equipment are now used for these procedures and that may be an important reason in limiting its further spread. Secondly, a highly probable reason for the complete eradication of genotype 2a may be due to the high sustained virological response rates seen for this particular genotype (36). The results of a systematic review of HCV epidemiology in Asia, Australia and Egypt corresponds well with our observations (7).…”

Section: Discussionsupporting

confidence: 86%

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Zhang

Fan

Wang³

et al. 2012

Hepat Mon

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Background:The changing pattern of hepatitis C virus (HCV) infection could have a significant impact on future medical prevention practices and therapies. Objectives: The purpose of this study was to describe the changing pattern of HCV infection in southwest China using clinical epidemiology, and to assess the association between the genotypes distribution and certain potential risk factors. Patients and Methods: A retrospective analysis which included 1208 subjects with chronic HCV registered at the Southwest Hospital (Chongqing, Southwest China) was performed. The information was reviewed and the data collected from clinical records and short telephone interviews when necessary. HCV genotypes were determined by nucleotide sequencing of the CE1 regions followed by phylogenic analysis with the published HCV genotype. HCV genotype distribution was analyzed according to the patients' age, gender, risk exposure, and the initial risk exposure. Results: Among the 1 208 patients, the HCV subtype 1b was the most prevalent (32.9%), followed by subtype 3b (18.9%), 6a (18.0%), 3a (12.8%) and 2a (10.4%), while subtypes 1a and 6k accounted for cases of HCV infection in only 9 and 3 cases respectively. Individuals older than 40 years were mainly infected with subtypes 1b and 2a, whereas younger patients were predominantly infected with genotypes 3 and 6. Subtypes 1b and 2a were observed more frequently among 44.4% and 16.0% patients respectively, with a history of invasive operations. Subtypes 3b and 6a constituted the majority of HCV infections among intravenous drug users (IDUs) (28.7% and 34.9%, respectively). A significant difference (P < 0.001) was observed between the HCV genotype distributions, according to the potential route of infection. Conclusion: In southwest China, the most common remaining subtype is the 1b genotype, but this has declined significantly among young patients. This is followed by subtype 3b and 6a which has increased significantly, especially among young patients. The distribution of such genotypes was also variable according to gender and age. The changing pattern of HCV infection was associated with changes in the modes of HCV acquisition, which raises an alarm signal concerning the major steps that need to be taken in order to reduce such infections in southwest China.

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Section: Discussionsupporting

confidence: 86%

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Zhang

Fan

Wang³

et al. 2012

Hepat Mon

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“…The fact that older patients displayed lower rates of SVR is likely related to impaired cellular, humoral, and innate immunity, supporting earlier findings [15,16].…”

Section: Discussionsupporting

confidence: 82%

Relation of interleukin-1β gene to treatment response in chronic patients infected with HCV genotype 4

Omran

Ibrahim

Youssef

et al. 2013

J Infect Dev Ctries

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Introduction: Hepatitis C virus (HCV) infection results in chronic hepatitis in more than 70% of infected patients, while 20-30% of patients recover spontaneously. This strengthens the role of the host genetic factors in either spontaneous or drug-induced viral clearance. The aim of this study was to investigate the relationship between interleukin-1β +3953 gene polymorphism and the response to interferon therapy in chronic HCV patients infected with genotype 4. Methodology: The interleukin-1β (+3953 C/T) (rs1143634) gene was amplified in 115 chronic HCV patients. Interleukin-1β single nucleotide polymorphism (SNP) plus several clinical and pathological factors were statistically analyzed in correlation with response to therapy. Results: Genotypes C/T and T/T had a significant association with non-response to treatment compared to genotype C/C, which had a strong association with response to treatment (95% confidence; 6.4884-48.5818, p = 0.0001). Furthermore, analysis of allele frequency in this cohort revealed that the T allele is associated with non-response, higher fibrosis, and higher hepatic activity, while the C allele had a significant association with sustained virologic response lower fibrosis, and lower hepatic activity (p value = 0.0001). Conclusion: This is the first study to examine the correlation between interleukin-1β (+3953 C/T) (rs1143634) gene polymorphism and the response of interferon therapy in genotype 4 HCV-infected patients. The results encourage further assessment of this SNP as a marker to predict response to therapy and disease progression, which can have major implications in saving money, time, and in avoiding unnecessary adverse effects.

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“…A younger patients less than 40 years of age, were found to have a higher SVR rate compared with the older ones. This however, is an agreement with other studies, who reported that SVR rate in older patients was remarkably low at 17.4% compared to SVR rate in all patients included in study which was 36.0% these results were in disagreement with other studies carried in Pakistan where a significant relationship between age group and SVR as they found younger patients had higher SVR [31,32].…”

Section: Discussionsupporting

confidence: 79%

The role of hepatitis C virus genotyping in evaluating the efficacy of INF-based therapy used in treating hepatitis C infected patients in Libya

Daw¹,

Elasifer²,

Dau³

et al. 2013

Virol Discov

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Background: Hepatitis C virus (HCV) therapy has been evolved over years and many parameters were used to evaluate such therapy particularly genotyping. In North Africa and Eastern Mediterranean the genotypes vary from most of world and rarely studies were conducted to assess the influence of such genotypes on the HCV therapy. Aims: This study was designed to determine; the role of HCV genotyping in assessing the efficacy of interferon therapy and to analyze the rates of sustained virological response (SVR) in INF and PegIFN-based regimens according on HCV genotype infecting Libyan patients with chronic hepatitis C infection. Methods: A total of 479 patients with chronic HCV registered at Tripoli Medical Centre were treated with 'INF alfa or PEG-INF-Pegylated INF alfa 2a in combination with ribavirin' for a five year period. These patients were registered and followed up from January 2007 to October 2012. The information were reviewed and data were collected from each patient regarding age, gender, ALT level, and viral load, viral genotype using qualitative PCR. The statistical analysis were carried using SPSS version 11.5. Results: Of the patients studied 86 patients were treated with INF based regimen, only 54% of them had end treatment response (ETR) and 28% had SVR. Off 143 patients treated with peg-INF alfa 2a based therapy; 69% had ETR and 36% had SVR. The SVR of Peg-INF based regimen was higher than INF based regimen in all genotypes except for genotype 4. The relationship between SVR and gender was significant in patients who were given INF based therapy comparable to PEG INF based regimen, though the relationship between SVR and age, basal viral load and basal ALT were also reported in both regimens. Conclusions: HCV genotyping has been found to play an important valuable role in determining the efficacy of Hepatitis C therapy. SVR vary according to the HCV genotype involved. HCV genotype 1 and 4 were found to be the prevalent resistant genotypes infecting Libyan patients. Such findings are particularly important in guiding the clinical therapy of patients infected with hepatitis C virus.

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A study of best positive predictors for sustained virologic response to interferon alpha plus ribavirin therapy in naive chronic hepatitis C patients

Cited by 62 publications

References 19 publications

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Changing Pattern of Clinical Epidemiology on Hepatitis C Virus Infection in Southwest China

Relation of interleukin-1β gene to treatment response in chronic patients infected with HCV genotype 4

The role of hepatitis C virus genotyping in evaluating the efficacy of INF-based therapy used in treating hepatitis C infected patients in Libya

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