2016
DOI: 10.18203/2319-2003.ijbcp20164777
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A study of antinociceptive effect of venlafaxine in albino mice

Abstract: Background: Serotonin and norepinephrine are important neurotransmitters involved in pain inhibition in descending pain inhibitory tracts. Venlafaxine being an antidepressant exerts its mechanism mainly by inhibiting reuptake of serotonin and norepinephrine like Tramadol. The objectives were to study the antinociceptive activity of Venlafaxine and its comparison with Pethidine.Methods: A total of 32 Swiss albino mice were divided into 4 groups with 8 animals in each group. Group 1 received normal saline as con… Show more

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“…Venlafaxine being an antidepressant exerts its mechanism mainly by inhibiting reuptake of serotonin and norepinephrine like tramadol [13]. In a study conducted in mice using the same two experimental models, it was seen that tramadol exhibits significant antidepressant activity and it was comparable to tricyclic antidepressant, desipramine [14].…”
Section: Discussionmentioning
confidence: 99%
“…Venlafaxine being an antidepressant exerts its mechanism mainly by inhibiting reuptake of serotonin and norepinephrine like tramadol [13]. In a study conducted in mice using the same two experimental models, it was seen that tramadol exhibits significant antidepressant activity and it was comparable to tricyclic antidepressant, desipramine [14].…”
Section: Discussionmentioning
confidence: 99%