A study of angiographic severity in patients with coronary artery disease and hyperuricemia

Abstract

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

Correlation between Serum Uric Acid Level and Severity of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome

“…The systematic review of the five articles showed a positive correlation between uric acid level and severity of coronary artery stenosis (Gensini score) in ACS patients. 6,[9][10][11][12] the relationship between SUA and severity of coronary atherosclerosis evaluated via endothelial dysfunction using peripheral arterial tone (PAT The secondary outcome demostrated that compared to normouricemia, hyperuricemia in ACS patients was associated with severity, wound area, and total occlusion number. 6,10-number of diseased vessels, critical lesions and total occlusions on coronary angiogram.…”

Korelasi Kadar Asam Urat Serum dengan Keparahan Stenosis Arteri Koroner Pasien Sindrom Koroner Akut: Studi Meta-Analisis

“…Berdasarkan hasil telaah sistematis dari kelima artikel, didapatkan adanya korelasi positif antara kadar asam urat serum dengan keparahan stenosis arteri koroner (skor Gensini) pada pasien SKA. 4,9,[16][17][18] Hasil luaran lain dari telaah sistematis ini menunjukkan bahwa normourisemia pasien dengan hiperuresemia pada pasien SKA berhubungan dengan keparahan, luas lesi dan jumlah oklusi total arteri koroner. 9,[16][17][18] Hasil telaah sistematis didapatkan lima penelitian yang layak untuk dianalisis menggunakan program CMA3, untuk melihat korelasi kadar asam urat serum dengan skor Gensini.…”

“…Masingmasing penelitian mencantumkan data karakteristik dasar faktor risiko kardiovaskular termasuk hipertensi, diabetes melitus, dislipidemia, 4,9,17 dan merokok. 4,9,16,17 Namun, pada penelitian lain mengeklusi diabetes melitus 16,18 ataupun hipertensi 16 dalam penelitiannya. Masing-masing penelitian juga menunjukkan perbedaan persentase tipe klinis pasien SKA baik UAP, NSTEMI, dan STEMI, 9,[16][17][18] sedangkan satu penelitian lainnya hanya meneliti pasien SKA dengan tipe klinis UAP dan NSTEMI.…”

“…4,9,16,17 Namun, pada penelitian lain mengeklusi diabetes melitus 16,18 ataupun hipertensi 16 dalam penelitiannya. Masing-masing penelitian juga menunjukkan perbedaan persentase tipe klinis pasien SKA baik UAP, NSTEMI, dan STEMI, 9,[16][17][18] sedangkan satu penelitian lainnya hanya meneliti pasien SKA dengan tipe klinis UAP dan NSTEMI. 4 Perbedaan karakteristik partisipan yang meliputi faktor risiko kardiovaskular termasuk usia, jenis kelamin pria, hipertensi, dislipidemia maupun diabetes melitus dan adanya perbedaan tipe klinis pasien SKA dari masingmasing studi, tentunya akan menyebabkan adanya heterogenitas dalam penelitian ini.…”

Effect Of Dragon Fruit Juice (Hylocereus Polyrhizus) On Xanthine Oxidase Activity And Blood Nitric Oxide Levels On Rats With Hyperuricemia

“…Hyperuricemia is a metabolic disease with increased serum uric acid levels as a result of increased uric acid formation or reduced uric acid excretion by the kidneys, or both ratiwi (Maruhashi T, 2013) (Thottam et al, 2017). Hyperuricemia is not only a risk factor for gout, but also a major determinant of hypertension, diabetes mellitus, chronic kidney disease, and cardiovascular disease (Kim et al, 2018) (Pramanik et al, 2015). Several studies have shown a significant role of hyperuricemia in the occurrence of vascular endothelial dysfunction which is the main mechanism in triggering atherosclerosis.…”