A Study of an Ocular Infection Induced Experimentally with Bacterium Monocytogenes

Morris, Marion C.; Julianelle, L. A.

doi:10.1016/s0002-9394(35)93550-4

Cited by 17 publications

(6 citation statements)

References 4 publications

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“…When cultures of L. monocytogenes are instilled into the conjunctival sac of rabbits, guinea pigs, or mice by means of a Pasteur pipette without scarifying the conjunctiva, a marked purulent conjunctivitis usually develops in 24 to 36 hr. This reaction was discovered independently and almost simultaneously by Anton (5) in Austria and Morris and Julianelle (161) in the United States. It is generally known as the "Anton reaction" even though Julianelle and Pons (118) were first to suggest this specific reaction as a rapid means of identifying suspect cultures.…”

Section: Characteristics Aiding Identification Ofmentioning

confidence: 87%

“…After the fifth postexposure day, the proportion of polymorphonuclear leukocytes increased until, by the tenth day, these cells predominated, giving the appearance of a purulent reaction. Congested capillaries, some of which showed proliferation of the endothelial lining, gave the appearance of pannus of the cornea (161). Occasionally there was hyperemia of the iris.…”

Section: Pathogenicity For Laboratory Animals Male or Nonpregnant Animentioning

confidence: 99%

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Listeria monocytogenes and listeric infections.

Gray¹,

Killinger²

1966

Bacteriological Reviews

530

309

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Section: Characteristics Aiding Identification Ofmentioning

confidence: 87%

Section: Pathogenicity For Laboratory Animals Male or Nonpregnant Animentioning

confidence: 99%

Listeria monocytogenes and listeric infections.

Gray¹,

Killinger²

1966

Bacteriological Reviews

530

309

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“…Remarkably but consistent with observations from naturally infected animals, in some instances bacteria can be isolated from experimentally inoculated animals in the absence of clinical symptoms or pathological lesions, albeit bacterial concentrations are likely low since cultures had to be kept at refrigerated temperatures for several weeks to culture L. monocytogenes from the animal tissues, thereby hampering the growth of background microflora and allowing the psychotropic bacteria to reach numbers sufficient for detection [ 23 , 117 ]. Ocular inoculation produces conjunctivitis and other eye infections in non-pregnant animals of various species including rabbits, guinea pigs and non-human primates, and exposed animals occasionally develop septicemia, meningitis or meningoencephalitis [ 23 , 118 - 120 ]. Non-human primates mostly develop mild and transient ocular symptoms while guinea pigs and rabbits develop severe symptoms and occasionally succumb to systemic infection [ 120 ].…”

Section: Experimental Infections Before Recognition As Foodborne Dmentioning

confidence: 99%

Animal models of listeriosis: a comparative review of the current state of the art and lessons learned

Hoelzer

Pouillot

Dennis

2012

Vet Res

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Listeriosis is a leading cause of hospitalization and death due to foodborne illness in the industrialized world. Animal models have played fundamental roles in elucidating the pathophysiology and immunology of listeriosis, and will almost certainly continue to be integral components of the research on listeriosis. Data derived from animal studies helped for example characterize the importance of cell-mediated immunity in controlling infection, allowed evaluation of chemotherapeutic treatments for listeriosis, and contributed to quantitative assessments of the public health risk associated with L. monocytogenes contaminated food commodities. Nonetheless, a number of pivotal questions remain unresolved, including dose-response relationships, which represent essential components of risk assessments. Newly emerging data about species-specific differences have recently raised concern about the validity of most traditional animal models of listeriosis. However, considerable uncertainty about the best choice of animal model remains. Here we review the available data on traditional and potential new animal models to summarize currently recognized strengths and limitations of each model. This knowledge is instrumental for devising future studies and for interpreting current data. We deliberately chose a historical, comparative and cross-disciplinary approach, striving to reveal clues that may help predict the ultimate value of each animal model in spite of incomplete data.

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“…Closely associated with virulence is a diagnostic test which has been studied in this laboratory and which is considered valuable for purposes of identification, since all 24 strains studied induced a similar response. The reaction already reported upon (Morris and Julianelle, 1935;Julianelle and Pons, 1939a) is essentially an infection of the conjunctiva and cornea of rabbits, guinea-pigs, and mice, but apparently not of the monkey (M. rhesus). The test is best performed by the instillation of one or two drops of a young broth culture into the conjunctival sac in one eye, while in the other eye, inoculation is effected by gentle massage of the conjunctiva of the everted lid with a swab previously moistened in the same culture.…”

Section: Biological Experimentsmentioning

confidence: 85%

Biological and Immunological Studies of Listerella

Julianelle

1941

J Bacteriol

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have dealt summarily with different aspects of the biological and immunological characteristics of the genus Listerella. The data now available after several years of intermittent study bring this phase of the work to a stage of completion, and it is desirable, therefore, to consolidate the information acquired into a single communication containing in extenso both the observations preliminarily reported upon, and the results of certain experiments hitherto unpublished. CULTURES AND METHODS Strains of Listerella employed. The strains utilized in this study conformed to the type description originally supplied by Murray, Webb, and Swann (1926). The chief distinctions adopted were colonial and microscopic size, ca. 1 to 2 mm. and ca. 0.5 X 1 IA respectively; retention of the gram stain, hemolytic activity, and motility; virulence for rabbit, guinea-pig, and mouse, and capacity to stimulate in susceptible animals an increase in the mononuclear elements of the blood. These characteristics will be amplified later in this report. There were 24 strains in all, and they were collected from different laboratories where they I Conducted under a grant from the Commonwealth Fund of New York. 2 Cultures of Listerella were obtained from Drs.

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A Study of an Ocular Infection Induced Experimentally with Bacterium Monocytogenes

Cited by 17 publications

References 4 publications

Listeria monocytogenes and listeric infections.

Listeria monocytogenes and listeric infections.

Animal models of listeriosis: a comparative review of the current state of the art and lessons learned

Biological and Immunological Studies of Listerella

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