A study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis

Somani, V K

doi:10.4103/0378-6323.39689

Cited by 23 publications

(28 citation statements)

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“…Differently from other cohort studies that point to egg white (Kulig et al 1999;Nickel et al 1997), CM was the main culprit in this study, and the reason for that may lie in the fact that low-aged children and mild cases prevailed in our sample. These peculiarities probably also corroborated to the lower sensitization rate found in this study when it is compared with results reported in the literature (Kulig et al 1998;Nickel et al 1997;Somani 2008;Wahn et al 2008).…”

Section: Discussionsupporting

confidence: 76%

“…In this study, a 1.001-fold increase in the odds ratio of sensitization to foods in each added unit of IgE was observed. However, it was not possible to establish a correlation between the (Laske and Niggemann 2004;Somani 2008). The age group with 36 months of age or less showed the highest concentration of sIgE level, and over half of these infants presented this feature during their first year of life (52.6 %), indicating that sensitization really occurs in the beginning of life according to the data from the studies early treatment of the atopic child-ETAC (1998) and multicentre allergy study-MAS (Kulig et al 1998).…”

Section: Discussionmentioning

confidence: 99%

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Response of Specific Immunoglobulin E to Foods in Children with Atopic Dermatitis

Passeti

Fonseca

Wandalsen

2014

Arch. Immunol. Ther. Exp.

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Food allergy is a common condition that plays an important role in the pathogenicity and maintenance of atopic dermatitis (AD), however, must be carefully investigated before imposing a restrictive diet. The aim of this study was to evaluate the sensitivity to foods in patients with AD, correlating it with the severity of the disease and other possible associated factors. One hundred and eleven children (6-180 months of age) with AD were evaluated and later followed up at the Allergy and Clinical Immunology Division, Department of Pediatrics at FMABC. The serum concentrations of specific IgE to cow's milk (CM), egg, soy, wheat, corn, peanut and fish were measured using an enzymatic fluorescence method (ImmunoCAP TM ). In order to identify the clinical reactivity, the open oral provocation test was performed when specific IgE was positive to CM, egg and wheat and in all those who related symptoms after the intake of such foods regardless of the presence or absence of sensitization. In total, 40.5 % of the studied population was sensitized to at least one food allergen, especially those between 73 and 180 months of age. There was a higher prevalence of sensitization in children with more severe AD, and foods like CM, egg and wheat were the most involved, but with low clinical reactivity. We observed increased severity of AD in cases that initiated symptoms earlier and who had shorter duration of exclusive breastfeeding as well as a linear increase in sensitization in the most serious cases. Serum-specific immunoglobulin E was the only factor associated with the relationship that showed sensitization. The occurrence of sensitization to foods was frequent, mainly in the age group of 6-9 years and in patients with severe AD; however, the validation of the clinical reactivity was negative in most of the provocations performed, which agrees with the need to prove the same before the imposition of restrictive diets, often unnecessary and complex.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Response of Specific Immunoglobulin E to Foods in Children with Atopic Dermatitis

Passeti

Fonseca

Wandalsen

2014

Arch. Immunol. Ther. Exp.

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“…This study also noted an age dependence in the pattern of sensitizations. Sixty-five percent of the children under the age of 10 were positive to one or more food allergens; sensitivity to food allergens was more common in those below 10, while that to aeroallergens was more common in the older age children [12].…”

Section: Prevalence Of Allergic Sensitization In Patients With Atopicmentioning

confidence: 99%

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

Liu

Goodarzi

Chen

2011

Clinic Rev Allerg Immunol

386

307

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Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.

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“…5 Allergic rhinitis along with bronchial asthma, atopic dermatitis and allergic conjunctivitis is included in atopic group of diseases. 7 Allergic rhinitis/conjunctivitis and allergic asthma are characterized by a T(H) 2-dominated immune response associated with increased serum IgE levels in response to inhaled allergens. Because IgE is a key player in the induction and maintenance of allergic inflammation, it represents a prime target for therapeutic intervention.…”

Section: Discussionmentioning

confidence: 99%

A clinical study of inhalant allergens in patients with allergic rhinitis

Choudhari

Sangavi

2017

Int J Otorhinolaryngol Head Neck Surg

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INTRODUCTIONImmunoglobulin E (IgE) predominantly mediates immunity and immune responses against parasitic infections, but it is also an essential component of type I hypersensitivity reaction, which can cause anaphylaxis, asthma, atopic dermatitis, and allergic rhinitis.1 Allergic rhinitis was defined in 1929, it is a symptomatic disorder of the nose induced after allergen exposure by an immunoglobulin E (IgE)-mediated inflammation of the membranes lining the nose. It is a global health problem that causes major illness and disability worldwide. The three cardinal symptoms in nasal reactions occurring in allergy are sneezing, nasal obstruction and mucous discharge.2 It is the cause, coexisting disorder or predisposing factor in many cases of chronic sinusitis, serous otitis, increased susceptibility to upper and lower respiratory infections and orthodontic disorders such as overbite and maldeveloped dental archs. 3The basis of any diagnosis of allergy requires a good history and examination, which should then provide a certain degree of confidence as to whether or not allergy is present. However, the diagnosis cannot be confirmed on the basis of symptoms alone, because both allergic and non-allergic conditions can present with similar symptoms. Hence, allergy testing in the form of specific IgE (sIgE) measurement is an important aid in demonstrating both the presence and severity of such an allergy. 4 ABSTRACT Background:The basis of diagnosis of allergy requires a good history and examination, however, the diagnosis cannot be confirmed on the basis of symptoms alone, because both allergic and non-allergic conditions can present with similar symptoms. Hence, allergy testing in the form of specific IgE (sIgE) measurement is an important aid in demonstrating both the presence and severity of such an allergy. The present study was undertaken to find out the common environmental allergens prevailing in Raichur causing allergic rhinitis, using carbohydrate cross reactive determinants (CCD), an in vitro test with high degree of sensitivity.Methods: The present prospective study was conducted among 30 patients with allergic rhinitis. A detailed general and ENT examination were done, X-ray of PNS, CT scan of PNS, diagnostic nasal endoscopy and nasal smear examination for eosinophils, absolute eosinophil count and serum IgE levels using Euroimmun system of in vitro assay of specific IgE antibodies. Results: Allergy to dust mite, D. faranie, corn, carnation flower, sunflower, sheep wool and straw dust were the most frequent allergens causing allergic symptoms among patients in Raichur area. Total serum IgE was elevated in all the patients, 60% were allergic to dust mite as found by anti CCD specific IgE. Conclusions: Antibodies to dust mite D. faranie, rye, T. mothy grass was the commonest finding. Identification of inhalant allergens is an important factor in prevention and treatment of allergic rhinitis.

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A study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis

Cited by 23 publications

References 0 publications

Response of Specific Immunoglobulin E to Foods in Children with Atopic Dermatitis

Response of Specific Immunoglobulin E to Foods in Children with Atopic Dermatitis

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

A clinical study of inhalant allergens in patients with allergic rhinitis

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