A study of affecting the recovery of Chinese patients with Bell palsy

Abstract

We explored the risk factors for preventing recovery of Bell palsy (BP) in Chinese inpatients. Five hundred thirteen patients were included. The two end-points of assessment were the discharge and final follow-up results. Relationship between discharge and baseline: long patients delay (unhealed 4.03 ± 1.16 d vs improved 2.24 ± 1.0 d, P < .001), combined diseases (yes 77.06% vs no 86.71%, P = .01), and early use of acupuncture (yes 47.46% vs no 97.62%, P < .001) were bad factors. Therapeutic factors and discharge: only use of steroids was a positive factor (yes 92.54% vs no 57.30%, P < .001). Binary logistic regression found that early use of steroids was a favorable factor (P = .001), while early use of acupuncture (P < .001) and long patient delay (P < .001) were adverse factors. Subgroups analysis showed early use of steroids plus antivirals (steroids + antivirals vs antivirals + mecobalamin, P < .001) and early use of steroids plus mecobalamin were good choices (steroids + antivirals vs steroids + mecobalamin, P = .745), while early use of antivirals plus mecobalamin was a bad choice (vs other 2 groups, P < .001). Effect of drug dose and treatment course on discharge: long time use of steroids didn’t mean good efficacy (unhealed 10.80 ± 1.53 d vs improved 10.38 ± 1.21 d, P = .026). Final follow-up results: improved patients were better than that of unhealed at discharge (P < .001). Risk factors of discharge included long patient delay, combined diseases, and early use of acupuncture. Steroids plus antivirals or steroids plus mecobalamin were good choices for treatment. Long time use of steroids didn’t mean good effect. Improved patients at discharge had better results finally.

Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection

“…Today, multiple treatments and drugs have no significant effect on Bell's palsy, the most common form of peripheral facial palsy (Gronseth and Paduga, 2012 ; Zandian et al, 2014 ; Newadkar et al, 2016 ; Zhang et al, 2019 ). Antivirals and steroids were the most commonly prescribed medications in the early days of Bell's palsy (Jalali et al, 2021 ).…”

Bell’s Palsy: A Review

“…(21)(22)(23) (The use of steroids plus antivirals and the use of steroids plus mecobalamin are 2 good choices.) (24) MIRE therapy in which infrared light of wavelength 890nm, is used on the area anterior and posterior to the ear, the temporal and lower jaw area of the affected side for the half-anhour cycle. (25,26) When a case of facial palsy comes to a dentist,the following can be followed: thorough history taking and physical examination to exclude all possible causes for facial palsy, routine laboratory testing, and diagnostic imaging should be avoided if it is a new case of Bell's palsy, oral steroids (prednisolone) can be given within 72 hours of the appearance of symptoms,(For adults who come within 72 hours of onset treatment recommendations are " Corticosteroids: Prednisone 50 mg orally daily for 5 days, followed by 10 mg less each day for 5 days, Prednisolone 50 mg OD for 10 days, Antivirals: Valacyclovir 1 g TID for 7 days, Acyclovir 400 mg OD five times daily for 7 days)."…”