A Study of 500 Cases of Acute Renal Failure (1978-1991)

Firmat, J; Zucchini, A; Martín, Raquel Barba; Aguirre, Cristina

doi:10.3109/08860229409044850

Cited by 19 publications

(4 citation statements)

References 4 publications

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“…There is paucity of data on epidemiology of AKI in Latin America. Some studies were performed in tertiary level hospitals from large cities [6,7,8]. Others have focused on specific conditions such as tropical disease, envenomation by snakebites, spiders, bees, and pregnancy complications [9–12].…”

Section: Discussionmentioning

confidence: 99%

EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

et al. 2019

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IntroductionEpidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding.MethodsObservational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model.ResultsFifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50–74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%.ConclusionsAKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.

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Section: Discussionmentioning

confidence: 99%

EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

et al. 2019

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“…As such, it has numerous causes, occurs in a wide range of patients, and continues to have a poor prognosis despite the development of modern techniques for treatment [1,6,12]. Several attempts have been made to derive prognostic factors for adult patients with AKI, and various risk factors have been proposed [2,3,5,[12][13][14][15][16][17][18][19][20][21][22][23][24][25]. This prospective study was undertaken with the goal of identifying factors which predict outcome and mortality rate of AKI for children in the pediatric intensive care unit.…”

Section: Discussionmentioning

confidence: 99%

Prognosis for children with acute kidney injury in the intensive care unit

et al. 2009

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To define factors of prognostic importance for critically ill infants and children with acute kidney injury (AKI), we have studied 110 children, ages from 1 month to 180 months, admitted between March 1, 2002 and September 30, 2004 to the intensive care unit of Joana de Gusmão Children's Hospital. These patients represent 8% of all intensive care unit admissions during the entire study period. The diagnosis at admission was primary renal parenchyma disease (eight patients, 7.2%) and secondary renal disease (102 patients, 92.8%). Thirty-seven patients (33.6%) died, all of whom had secondary renal insufficiency; six patients (5.4%) died as a result of septic shock, and 31 (28.2%) patients died from multiple organ failure (MOF). The variables were analyzed using Fisher's exact test for qualitative variables and Student's t-test for quantitative variables. Stratified analysis was performed to assess the relative importance of variables using the Mantel-Haenszel technique. Among the variables analyzed, the following were found to be significantly related to mortality: anuria, oliguria, arterial hypotension, need for pressor drugs, need for mechanical ventilation, need for dialysis, the association with MOF, and high values of lactic acid.

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“…[112][113][114][115][116][117] Septic abortion is the cause of AKI in 52% of patients in Ethiopia, 118 and in Argentina and Nigeria, gynaecological and obstetric complica tions still account for about onethird of patients with AKI. 112,113,119 In one hospital in Pakistan, of 100 patients with obstetric AKI seen over a 3year period, over 90% needed dialysis, 7% died in h ospital, and only 44% were off dialysis at discharge. 114…”

Section: Obstetric Complicationsmentioning

confidence: 99%

Community-acquired acute kidney injury in tropical countries

Jha¹,

Parameswaran

2013

Nat Rev Nephrol

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Community-acquired acute kidney injury (AKI) in developing tropical countries is markedly different from AKI in developed countries with a temperate climate, which exemplifies the influence that environment can have on the epidemiology of human diseases. The aetiology and presentation of AKI reflect the ethnicity, socioeconomic factors, climatic and ecological characteristics in tropical countries. Tropical zones are characterized by high year-round temperatures and the absence of frost, which supports the propagation of infections that can cause AKI, including malaria, leptospirosis, HIV and diarrhoeal diseases. Other major causes of AKI in tropical countries are envenomation; ingestion of toxic herbs or chemicals; poisoning; and obstetric complications. These factors are associated with low levels of income, poor access to treatment, and social or cultural practices (such as the use of traditional herbal medicines and treatments) that contribute to poor outcomes of patients with AKI. Most causes of AKI in developing tropical countries are preventable, but strategies to improve the outcomes and reduce the burden of tropical AKI require both improvements in basic public health, achieved through effective interventions, and increased access to effective medical care (especially for patients with established AKI).

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A Study of 500 Cases of Acute Renal Failure (1978-1991)

Cited by 19 publications

References 4 publications

EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America

Prognosis for children with acute kidney injury in the intensive care unit

Community-acquired acute kidney injury in tropical countries

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