A study of 32 food-related deaths from anaphylaxis: Ontario; 1986–2000

Mehra, Saral; Salter, Jane; Sussman, Gordon; Cairns, Jim; Vadas, Peter

doi:10.1016/s0091-6749(02)81673-6

Cited by 3 publications

(2 citation statements)

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“…Failure to use epinephrine, or to use it promptly is considered to be an important and avoidable factor in fatal reactions [ 5 , 17 – 21 ]. Combining the data of Bock and Pumphrey in cases of fatal food anaphylaxis, only 5 of 80 patients had administered epinephrine appropriately [ 2 , 3 ].…”

Section: Reviewmentioning

confidence: 99%

“…Asthma is probably the most significant risk factor for death from food allergy anaphylaxis, with case series finding 69–100 % of patients having pre-existing asthma [ 2 , 3 , 5 , 13 , 18 – 21 , 25 ]. Summers and colleagues reported that allergic burden contributes to the severity of allergic reactions in patients with nut anaphylaxis [ 26 ].…”

Section: Reviewmentioning

confidence: 99%

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Risk multipliers for severe food anaphylaxis

Smith

Hourihane

Lieberman

2015

World Allergy Organization Journal

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Anaphylaxis is a severe, life threatening allergic reaction. In most fatal cases of food anaphylaxis, the fatality is not due merely to a simple, linear relationship between the allergen and exposure in a sensitized individual. Compounding factors such as the allergic disease burden—particularly the presence of asthma; comprehension of the potential severity of an event, training in the appropriate use of epinephrine, and emerging metabolic factors should be considered when assessing risk and establishing management strategies. This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Risk multipliers for severe food anaphylaxis

Smith

Hourihane

Lieberman

2015

World Allergy Organization Journal

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Managing Risks and Preventing Food Allergy Incidents: A Regulator's Perspective

Godefroy¹,

Dubois²,

Vieille³

2010

Allergen Management in the Food Industry

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Use of epinephrine in the treatment of anaphylaxis

Lieberman

2003

Current Opinion in Allergy and Clinical Immunology

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Several major themes have emerged from this review of the recent literature. The finding that the intramuscular route of administration for epinephrine is superior has now been recognized by the guidelines, and because the site of choice has been found to be the lateral aspect of the thigh, the needle used for injection must be long enough to penetrate the vastus lateralis muscle. The reasons for the underutilization of epinephrine in the treatment of anaphylaxis are also discussed. Other important findings include the fact that outdated EpiPens can usually be administered safely, and alternative routes of administration, which may be more acceptable to patients, may be on the horizon as a result of preliminary studies assessing the administration of sublingual epinephrine by wafer. Finally, it is now understood that epinephrine prescription data may be one of our best tools to study the epidemiology and incidence of anaphylactic episodes.

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A study of 32 food-related deaths from anaphylaxis: Ontario; 1986–2000

Cited by 3 publications

References 0 publications

Risk multipliers for severe food anaphylaxis

Risk multipliers for severe food anaphylaxis

Managing Risks and Preventing Food Allergy Incidents: A Regulator's Perspective

Use of epinephrine in the treatment of anaphylaxis

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