A Study of 135 Cases of Carcinoma in Situ of the Cervix at the Free Hospital for Women

Younge, Paul A.; Hertig, Arthur T.; Armstrong, Dorothy

doi:10.1097/00006254-195008000-00040

Cited by 6 publications

(7 citation statements)

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“…9,16 Younge reported a prospective experiment on the natural history of CIS which was terminated in 1938 on account of the number of women who were observed to progress to cervical cancer. 17 This was followed by Petersen's classic precytology study of 127 untreated Danish women diagnosed in the years 1930-1950 with cervical precancerosis (usually designated CIS). Petersen reported 34 (26%) women developed invasive cancer during a 15 year follow-up.…”

Section: Natural History Studiesmentioning

confidence: 99%

Microscopes, microbes and molecules: Evolution of our understanding of the cause and natural history of the precursor lesions of squamous lower genital tract neoplasia*

Jones¹

2006

J of Obstet and Gynaecol

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Remarkable advances in cancer prevention, early diagnosis and treatment occurred during the second half of the 20th century, particularly in the field of cervical cancer. Increasingly, progress in the field of cervical cancer has been in molecular medicine, in particular the association between the human papilloma virus (HPV) and lower genital tract cancers. Sadly, however, disparities in health care between rich and poor communities continue to increase. Half a million new cases of cervical cancer occur in the world each year, of which more than 80% are in less developed countries. It is our challenge to address these inequalities. This paper will address the development of our knowledge and understanding of the cause, natural history and prevention of the common lower genital tract cancers. The clinical observations and techniques that provided the basis of our past knowledge and practice may, in low resource settings, provide methods which have a place in cervical cancer prevention today.Most papers on the epidemiology of cervical cancer mention the work of Rigoni-Stern, a mid-19th century Padua surgeon who noted that the ratio of deaths from breast cancer to deaths from cancer of the womb was far greater in nuns (and single women) than in other women.

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Section: Natural History Studiesmentioning

confidence: 99%

Microscopes, microbes and molecules: Evolution of our understanding of the cause and natural history of the precursor lesions of squamous lower genital tract neoplasia*

Jones¹

2006

J of Obstet and Gynaecol

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“…These, it will be realized, will be performed on women mainly in the reproductive age; the mean age of patients with changes in the portio mucosa, as far as can be gathered, is about one decade below the mean age of patients with manifest cancer of the uterine cervix (7,16,26). Even with the present improvements in anaesthetic and operative technic, the operative mortality in total hysterectomy can hardly be expected to be less than about 0.5-1 yo; this figure cannot be ignored when, after all, we are concerned with changes the possible malignancy of which is uncertain, or a t any rate unclarified.…”

Section: O L a F P E T E R S E Nmentioning

confidence: 99%

Some Clinical and Histologic Observations on »Precanceroses» of the Portio Vaginalis Uteri

Petersen

1952

Acta Radiologica

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“…The relationship between intra-epithelial and invasive cervical cancer is generally accepted, but a number of recent clinical, cytological and histological studies have been concerned with whether chronic irritative and inflammatory cervical lesions showing basal-cell hyperplasia and advancing grades of squamous-cell dysplasia could be 2 -712861 premalignant. Such a spectrum of epithelial abnormalities may represent a chronological progression to carcinoma (2,4,11,22,23,27,28,30,40).…”

mentioning

confidence: 99%

Cancer of the Uterine Cervix in a Korean Biopsy Series: With a Study of the Age Distribution in 1889 Cases of Chronic Cervicitis, Dysplasia, Intra‐epithelial and Invasive Epidermoid Carcinoma

Wetteland¹

1971

Acta Obstet Gynecol Scand

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Invasive cervical carcinoma is the most commonly observed primary form of cancer in Korean females. This tumour constituted 37.6% of 1820 malignant tumours of known primary site encountered in a Korean surgical series at the Scandinavian‐sponsored National Medical Center in Seoul from December 1958 to August 1967. The age at diagnosis of invasive cervical cancer averaged 43.6 years, and the estimated population peak incidence was also within the fifth decade. Ninety‐five per cent of the cases were of the epidermoid type; the range of age among patients with adenocarcinoma was significantly greater than in those with epidermoid cancer. The age distribution of 1889 cases of simple chronic cervicitis, squamous‐cell dysplasia, intra‐epithelial neoplasia and invasive epidermoid carcinoma is presented and discussed. The observations in 1033 cases of progressive epithelial abnormalities are consistent with a linear regression of age at diagnosis on histological grade of epithelial alterations ranging from slight dysplasia to late invasive epidermoid cancer. Such an interrelation constitutes one among several circumstantial pieces of evidence that the morphological evolution of invasive epidermoid carcinoma passes through a spectrum of epithelial abnormalities. The present results support this concept of a step‐wise progression in epidermoid cervical carcinogenesis.

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A Study of 135 Cases of Carcinoma in Situ of the Cervix at the Free Hospital for Women

Cited by 6 publications

References 0 publications

Microscopes, microbes and molecules: Evolution of our understanding of the cause and natural history of the precursor lesions of squamous lower genital tract neoplasia*

Microscopes, microbes and molecules: Evolution of our understanding of the cause and natural history of the precursor lesions of squamous lower genital tract neoplasia*

Some Clinical and Histologic Observations on »Precanceroses» of the Portio Vaginalis Uteri

Cancer of the Uterine Cervix in a Korean Biopsy Series: With a Study of the Age Distribution in 1889 Cases of Chronic Cervicitis, Dysplasia, Intra‐epithelial and Invasive Epidermoid Carcinoma

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