A Study for Cytological Behavior of Colorectal Carcinoma from the Viewpoint of Histological Type and Ki-67 Labeling Index in the Infiltrated Region of Tumor.

Funahashi, Kimihiko; Tsujita, Kazunori; Miki, T; Koike, Junki; Ogai, Tadahisa; Nagasawa, Yasushige; Kobayashi, Kazuo; Yanagita, K.; Terada, Yoshio

doi:10.5833/jjgs.30.846

Cited by 4 publications

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“…The Ki-67 L.I. of AC was reported to be 43.9 ± 13.7% in the most verti- cally infiltrated region (2). Hence, the proliferative activity of colorectal carcinomas should be evaluated in the most vertically infiltrated region, and our data for AC in the control cases were similar and reliable.…”

Section: Discussionsupporting

confidence: 52%

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Advanced Colorectal Carcinomas Measuring 20 mm or Less Exhibit Markedly Higher Invasiveness Despite Their Size

et al. 2004

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To analyze the biology of small (20 mm or less) advanced colorectal carcinomas (SAC), 24 cases, 22 small early colorectal carcinomas (SEC) of similar size, and 52 advanced colorectal carcinomas (AC) were studied. The proliferative (Ki-67) labeling index for SAC was 65.9+/-17.1%, significantly higher than those for SEC (30.9+/-13.7%) or AC (43.0+/-17.1%) (P < 0.01). Matrix metalloproteinase (MMP)-9 and tissue inhibitors of metalloproteinase (TIMP)-2 expressions for SAC were 62.5 and 79.2%, respectively, significantly higher than those for SEC (4.5, 13.6%) or AC (21, 33%) (P < 0.01). Small advanced carcinomas have higher invasiveness than SEC or AC and may represent a different type of cancer.

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Section: Discussionsupporting

confidence: 52%

“…Tumor growth is dependent on cell proliferation (1,2), and invasiveness is associated with various factors such as matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) (3,4).…”

Section: Introductionmentioning

confidence: 99%

Advanced Colorectal Carcinomas Measuring 20 mm or Less Exhibit Markedly Higher Invasiveness Despite Their Size

et al. 2004

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“…Ki-67 protein is found in the nuclei of cells in the growth period from late G1 phase through the M phase, and an association between the Ki-67 LI and the clinicopathologic factors and hepatic metastasis has been reported. [13][14][15] Funabashi et al 16 determined the Ki-67 LI at the invasive front of cancers, being the site of infiltration, by immunostaining using MID-1 antibody and assessed its relationship to histologic factors. They noted a correlation with histologic grade, lymph node involvement, and Dukes' class.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Thymidine Phosphorylase Staining and the Ki-67 Labeling Index to Clinicopathologic Factors and Hepatic Metastasis in Patients with Colorectal Cancer

et al. 2002

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“…Terabe 7 reported an average Ki67 positivity rate of 38.5% in colorectal cancer. Funabashi et al 8 reported that the Ki67 positivity rates according to the histological subtype were as follows: well, 39.14 ± 13.26%; moderate, 48.83 ± 2.88%; signet, 59.85 ± 13.60%; and mucinous, 59.60%. The Ki67 antigen positivity rate is negatively correlated with the degree of differentiation.…”

Section: Discussionmentioning

confidence: 99%

A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma

et al. 2022

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A 36‐year‐old woman visited our hospital with a chief complaint of bleeding during defecation. Colonoscopy revealed a 20‐mm pedunculated polyp in the sigmoid colon, which was en bloc resected under endoscopy. The histopathological diagnosis was adenoma cancer with a depth of invasion indicating mucosal cancer, no lymphovascular invasion, and negative at the resection margin. The poorly differentiated adenocarcinoma component comprised approximately 5% of the tumor. Although there were no recurrence signs in the computed tomography scans obtained 4 months post polypectomy, the patient experienced aggressive lower back pain at 6 months post polypectomy. Local recurrence, peritoneal dissemination, and liver metastasis were confirmed. Finally, the patient died following a rapid and aggressive deterioration of her general condition. Histological examination of the local recurrence revealed a poorly differentiated adenocarcinoma (por2), with immunostaining revealing a high Ki67 positivity rate of 95%. Moreover, the poorly differentiated adenocarcinoma region of the resected polyp had a Ki67 positivity rate of 90%, which suggested that they were the same tumors. These findings suggested that the recurrence could have occurred through implantation.

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A Study for Cytological Behavior of Colorectal Carcinoma from the Viewpoint of Histological Type and Ki-67 Labeling Index in the Infiltrated Region of Tumor.

Cited by 4 publications

References 0 publications

Advanced Colorectal Carcinomas Measuring 20 mm or Less Exhibit Markedly Higher Invasiveness Despite Their Size

Advanced Colorectal Carcinomas Measuring 20 mm or Less Exhibit Markedly Higher Invasiveness Despite Their Size

Correlation of Thymidine Phosphorylase Staining and the Ki-67 Labeling Index to Clinicopathologic Factors and Hepatic Metastasis in Patients with Colorectal Cancer

A case of rapidly progressing and poorly differentiated Ip‐type early‐stage colorectal adenocarcinoma

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