A structure-activity study on the influence of phenolic compounds and bioflavonoids on rat renal prostaglandin synthetase

Baumann, J.; Bruchhausen, Franz von; Wurm, G.

doi:10.1007/bf00506554

Cited by 63 publications

(18 citation statements)

References 24 publications

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“…Phloretin also inhibits several membrane transport mechanisms [30]. Flavonoids have been shown to inhibit prostaglandin synthetase [31,32]. Nevertheless, possible inhibition of platelet cyclo-oxygenase by flavonoids cannot be implied as the mechanism of inhibition of aggregation by ADP or thrombin, because it has been demonstrated that washed human platelets aggregate in the presence of ADP or thrombin independently of the formation of prostaglandin endoperoxide and thromboxane A 2 [33].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: Structure-activity relationships

Beretz

Cazenave

Anton³

1982

Agents and Actions

121

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Quercetin and 12 other natural flavonoid aglycones inhibit washed human platelet aggregation and secretion of serotonin induced by ADP, collagen or thrombin. The inhibitory effect of flavonoids is of the same order of magnitude as IBMX and dipyridamole. The structural features required for a flavonoid to inhibit human platelet function are similar to those previously reported by us to inhibit cyclic nucleotide phosphodiesterase. The inhibitory effect of flavonoids on human platelet function was diminished by saturation of the C-2, C-3 double bond, lack of the C-4 carbonyl, glycosylation at C-3 and a high number of hydroxyl substituents.

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Section: Discussionmentioning

confidence: 99%

Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: Structure-activity relationships

Beretz

Cazenave

Anton³

1982

Agents and Actions

121

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“…Figure 5 shows (14). However, the possibility that norepinephrine induces PG synthesis in dog renomedullary slices simply by its participation as a phenolic cofactor in the cyclooxygenation can be disregarded because much a higher concen tration (0.5-1 mM) of phenolic compounds seems to be required for this reaction (24,25) than for the stimulation of PG synthesis in our system (5 ,uM).…”

Section: Resultsmentioning

confidence: 94%

Different mode of action between norepinephrine and phenylephrine on prostaglandin synthesis by dog renal inner medullary slices.

1983

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Abstract-The dog renal inner medullary slices synthesized and released prostaglandin (PG) E2, PGF21, PGI2 (measured as 6-keto-PGF,.) and thromboxane (TX) A2 (measured as TXB2). When incubated in the presence of norepinephrine, the synthesis of these arachidonic acid metabolites were stimulated about 2-fold. The norepinephrine effect could be antagonized by the addition of an a-adrenoceptor blocking agent, phenoxy benzamine, but not by a Q-adrenoceptor blocking drug, propranolol. Phenoxybenzamine at concentrations that block norepinephrine stimulation of prostaglandin biosynthesis did not suppress the increase in prostaglandins synthesized by exogenous arachidonic acid. By contrast, phenylephrine caused only PGI2 production without producing other prostaglandins and thromboxane. This phenylephrine effect could not be antagonized by either a or 8-adrenoceptor blocking agents, but it was abolished by the specific PGI2 synthetase inhibitors 15-hydroperoxy arachidonic acid and tranylcypromine. These results suggest that norepinephrine-induced prostaglandin synthesis is mediated via an a-adrenergic receptor mechanism, whereas phenylephrine stimulation is primarily occurring at the step which follows the cyclooxygenase reaction in the metabolism of arachidonic acid.

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“…The hydrogen-donating ability of antioxidants is responsible for the reduction of DPPH radical to DPPHH [32,33]. In hydrazides and their metal complexes, a-or bhydrazinic nitrogen could be the site for removal of hydrogen radical required for the reduction of DPPH.…”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

Chemistry and antioxidant properties of titanium(IV) complexes

Shaikh

Ashiq

Jamal

et al. 2015

Transition Met Chem

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The synthesis of titanium(IV) complexes with biologically active hydrazide ligands has been carried out. The complexes were characterized by spectroscopic methods (IR, 1 H NMR and 13 C NMR), elemental analysis and conductivity studies. These studies suggest bidentate coordination of the ligands through carbonyl oxygen and primary amine nitrogen, resulting in octahedral geometries. Hydrazides with pyridyl substituents displayed 1:2 metalto-ligand ratio, and hydrazides with imino substituents exhibited 1:3 metal-to-ligand ratio resulting in an outer sphere complex. The remaining complexes displayed inner sphere coordination with 1:1 metal-to-ligand ratio. These complexes exhibit varying degrees of radical scavenging properties against DPPH, superoxide and nitric oxide free radicals. The free ligands showed inhibition against DPPH but were inactive against superoxide and nitric oxide free radicals. The structure-activity relationships of the complexes are discussed.

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A structure-activity study on the influence of phenolic compounds and bioflavonoids on rat renal prostaglandin synthetase

Cited by 63 publications

References 24 publications

Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: Structure-activity relationships

Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: Structure-activity relationships

Different mode of action between norepinephrine and phenylephrine on prostaglandin synthesis by dog renal inner medullary slices.

Chemistry and antioxidant properties of titanium(IV) complexes

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