A structurally precise Ag_xAu_25−x nanocluster based cancer theranostic platform with tri-targeting/in situ O₂-generation/aggregation enhanced fluorescence imaging/photothermal–photodynamic therapies

Abstract

The photothermal and photodynamic performances of structurally precise oil-soluble AgxAu25−x (x=1-13) nanoclusters were firstly explored and they were solubilized into new assemblies to form versatile cancer theranostic platform with tri-targeting/in-situ...

A multi-responsive Au NCs@PMLE/Ca2+ antitumor hydrogel formed in situ on the interior/surface of tumors for PT imaging-guided synergistic PTT/O2-enhanced PDT effects

“…Nevertheless, improving the tumor hypoxic microenvironment and enhance the PDT effect of Au NCs is rarely considered. Our group previously prepared the intelligent core-shell cancer therapeutic nanoplatform of Fe 3+ @Au 1 Ag 24 @PbP ( polyethylene glycol block grafted polyketal) 23 and Ag x Au 25−x @FHO (folic acid, hyaluronic acid, and octadecylamine)-Fe 3+ , 24 which possessed excellent responsive abilities to TME and enhanced PDT effect because the Fe 3+ ions added could catalyze the endogenic hydrogen peroxide (H 2 O 2 ) in the TME to generate oxygen (O 2 ). In addition, hydrogels have also attracted considerable attention because they play a role in inhibiting drug diffusion and cancer cell proliferation as well as provide locoregional therapy to the tumor.…”

Fused-Ring Small-Molecule-Based Bathochromic Nano-agents for Tumor NIR-II Fluorescence Imaging-Guided Photothermal/Photodynamic Therapy

“…Cancer theranostics that employ diagnostic imaging to study the heterogeneity of tumor and cellular phenotypes before initiating therapy have attracted extensive attention, which can achieve higher therapeutic effects guided by diagnostic imaging for more precision treatment. − Compared to traditional imaging techniques, fluorescence imaging with non-invasive, non-ionizing, and non-destructive features have promising potential in clinical applications, which generates a photoluminescent signal with intrinsic high spatial resolution and great sensitivity . Especially, the recently developed second near-infrared (NIR-II, 900–1700 nm) fluorescence imaging reduces much more autofluorescence and photon scattering from biological tissues and allows further tissue penetration depth and superior spatial resolution compared to the traditional NIR (780–900 nm) window in living bodies. − NIR-II fluorescence imaging has stimulated a widespread focus for tumor diagnostic imaging and has been applied for guiding the clinical resection of liver cancer using the weak fluorescence from the Food and Drug Administration-approved indocyanine green (ICG) .…”

Synthesis of Silica Nanoparticles with Physical Encapsulation of Near-Infrared Fluorescent Dyes and Their Tannic Acid Coating

“…For observing individual biological phenomena happening in vivo directly, fluorescence imaging is widely used because this method has noninvasive, nonionizing, and nondestructive features with intrinsic high spatial resolution and great sensitivity. 1 Especially, near-infrared (NIR) fluorescence imaging reduces much more autofluorescence from biological tissues and allows further tissue penetration depth compared to the imaging with visible light. 2 However, common NIR fluorescent dyes have some inherent problems such as poor solubility and low chemical stability.…”

“…Understanding biological activities properly has been a difficult task even today due to the very complexity and high diversity of organic living materials. For observing individual biological phenomena happening in vivo directly, fluorescence imaging is widely used because this method has noninvasive, nonionizing, and nondestructive features with intrinsic high spatial resolution and great sensitivity . Especially, near-infrared (NIR) fluorescence imaging reduces much more autofluorescence from biological tissues and allows further tissue penetration depth compared to the imaging with visible light .…”