A Structural Model for Chemotherapy Related Cognitive Impairment and Quality of Life in Breast Cancer Patients

Lee, Jung Ran; Oh, Pok Ja

doi:10.4040/jkan.2019.49.4.375

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…More specifically, the proportion of patients indicating moderate-to-severe depression requiring medication rose from 11.6% before chemotherapy to 23.5% during chemotherapy. Such a level of depression is greater than that of 17.2% reported by Korean breast cancer patients suffering from moderate-to-severe depression in another study that used the same measurement tool as the current study (Lee, 2016), but is less than the 32.0% reported in another study on colorectal patients receiving chemotherapy (Baek and Yi, 2015) and 30.0% reported by yet another study (Oh and Lim, 2017). Viewing depression in cancer patients as behavioral side effects from the cancer diagnosis itself and treatment on the disease, the severity of depression experienced by cancer patients is thought to increase when they experience various chemotherapy-related side effects.…”

Section: Discussioncontrasting

confidence: 71%

Changes in chemotherapy-induced peripheral neuropathy, disturbance in activities of daily living, and depression following chemotherapy in patients with colorectal cancer: A prospective study

Lee²,

Kim

et al. 2020

European Journal of Oncology Nursing

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Section: Discussioncontrasting

confidence: 71%

Changes in chemotherapy-induced peripheral neuropathy, disturbance in activities of daily living, and depression following chemotherapy in patients with colorectal cancer: A prospective study

Lee²,

Kim

et al. 2020

European Journal of Oncology Nursing

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“…In the present study, the cortical thickness of the medial frontal cortex and insular regions showed positive correlations, and the CSF volume of the third ventricle was negatively correlated with the degree of tumor differentiation in the chemotherapy group. It may be that the worse the tumor differentiation and the longer the average chemotherapy cycles, the more serious the damage to the medial prefrontal lobe and insular regions, and the greater the amount of CSF in the third ventricle ( 50 , 51 ). This situation was slightly different in the paired groups, mainly because the volumes of multiple brain regions distributed in the frontal, parietal, and occipital lobes were positively correlated with the duration after chemotherapy, except that the volume of the planum temporale was positively correlated with the differentiation degree of the tumor in the paired groups.…”

Section: Discussionmentioning

confidence: 99%

Brain morphological alterations and their correlation to tumor differentiation and duration in patients with lung cancer after platinum chemotherapy

Chen

et al. 2022

Front. Oncol.

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ObjectiveChemotherapy-related brain impairments and changes can occur in patients with lung cancer after platinum chemotherapy and have a substantial impact on survivors’ quality of life. Therefore, it is necessary to understand the brain neuropathological alterations and response mechanisms to provide a theoretical basis for rehabilitation strategies. This study aimed to investigate the related brain morphological changes and clarified their correlation with clinical and pathological indicators in patients with lung cancer after platinum chemotherapy.MethodsOverall, 28 patients with chemotherapy, 56 patients without chemotherapy, and 41 healthy controls were categorized in three groups, matched for age, sex, and years of education, and included in the cross-sectional comparison of brain volume and cortical thickness. 14 matched patients before and after chemotherapy were subjected to paired comparison for longitudinal observation of brain morphological changes. Three-dimensional T1-weighted images were acquired from all participants, and quantitative parameters were calculated using the formula of the change from baseline. Correlation analysis was performed to evaluate the relationship between abnormal morphological indices and clinical information of patients.ResultsBrain regions with volume differences among the three groups were mainly distributed in frontal lobe and limbic cortex. Additionally, significant differences in cerebrospinal fluid were observed in most ventricles, and the main brain regions with cortical thickness differences were the gyrus rectus and medial frontal cortex of the frontal lobe, transverse temporal gyrus of the temporal lobe, insular cortex, anterior insula, and posterior insula of the insular cortex. According to the paired comparison, decreased brain volumes in the patients after chemotherapy appeared in some regions of the frontal, parietal, temporal, and occipital lobes; limbic cortex; insular cortex; and lobules VI-X and decreased cortical thickness in the patients after chemotherapy was found in the frontal, temporal, limbic, and insular cortexes. In the correlation analysis, only the differentiation degree of the tumor and duration after chemotherapy were significantly correlated with imaging indices in the abnormal brain regions.ConclusionsOur findings illustrate the platinum-related brain reactivity morphological alterations which provide more insights into the neuropathological mechanisms of patients with lung cancer after platinum chemotherapy and empirical support for the details of brain injury related to cancer and chemotherapy.

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“…Depression was a significant factor contributing to "extreme memory problems". In a previous study by Lee [12], depression was found to be a factor that lowered the cognitive functions of patients with breast cancer undergoing chemotherapy. Additionally, there is a significant association between depression and low cognitive function in cross-country comparative studies [27].…”

Section: Journal Of Health Informatics and Statisticsmentioning

confidence: 89%

Factors Associated with Self-reported Memory Problems of Adult Cancer Survivors Based on the Korea National Health and Nutrition Examination Survey 2019

Ko¹

2023

J Health Info Stat

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Objectives: With the development of treatment technology, the percentage of cancer survivors has continued to increase. However, the cognitive decline these patients experience has been overlooked because it is not related to survival. This study investigated factors related to memory problems in patients with cancer.Methods: Using data from the 2019 Korea National Health and Nutrition Examination Survey (KNHANES), this secondary data analysis study attempted to identify factors related to memory problems in cancer survivors. Of the 8,110 survey participants, there were 6,296 adults, aged 19 years or older. Of these, 357 were diagnosed with cancer. Four participants were excluded due to missing values for occupation, income, and body mass index (BMI). Finally, 353 subjects were included in the research analysis. The data were statistically analyzed using IBM SPSS version 28.0.Results: 218 (61.8%) of the cancer survivors reported memory problems. Having a lower-than-average individual income (odds ratio, OR = 2.16, 95% confidence interval, CI = 1.31-3.53, p= 0.003), smoking (OR = 3.19, 95% CI = 1.16-8.72, p= 0.024), and depression (OR = 6.06, 95% CI = 1.33-27.57, p= 0.020) were significant potentiating factors. In contrast, having a job (OR = 0.18, 95% CI = 0.05-0.67, p= 0.011), drinking (OR = 0.26, 95% CI = 0.09-0.81, p= 0.021), and walking three to four days per week (OR = 0.15, 95% CI = 0.03-0.81, p= 0.027) decreased memory problems.Conclusions: Our findings suggest that it is necessary to develop cognitive rehabilitation programs for cancer survivors.

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A Structural Model for Chemotherapy Related Cognitive Impairment and Quality of Life in Breast Cancer Patients

Cited by 9 publications

References 31 publications

Changes in chemotherapy-induced peripheral neuropathy, disturbance in activities of daily living, and depression following chemotherapy in patients with colorectal cancer: A prospective study

Changes in chemotherapy-induced peripheral neuropathy, disturbance in activities of daily living, and depression following chemotherapy in patients with colorectal cancer: A prospective study

Brain morphological alterations and their correlation to tumor differentiation and duration in patients with lung cancer after platinum chemotherapy

Factors Associated with Self-reported Memory Problems of Adult Cancer Survivors Based on the Korea National Health and Nutrition Examination Survey 2019

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