2020
DOI: 10.1016/j.jmb.2019.12.016
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A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine

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Cited by 14 publications
(10 citation statements)
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“…Additionally, it was recently communicated that the I34-A3 base-pair is tightly dependent on the anticodon loop conformation and the modification state of neighboring bases ( Vangaveti et al, 2020 ). Alltogether, these observations highlight the role of base tautomerism in base pairing schemes related to the steric and geometric constraints imposed by the ribosome as originally discussed by Topal & Fresco ( Topal and Fresco, 1976 ).…”
Section: Possible Clues For the Absence Of Trna Genesmentioning
confidence: 99%
“…Additionally, it was recently communicated that the I34-A3 base-pair is tightly dependent on the anticodon loop conformation and the modification state of neighboring bases ( Vangaveti et al, 2020 ). Alltogether, these observations highlight the role of base tautomerism in base pairing schemes related to the steric and geometric constraints imposed by the ribosome as originally discussed by Topal & Fresco ( Topal and Fresco, 1976 ).…”
Section: Possible Clues For the Absence Of Trna Genesmentioning
confidence: 99%
“…Inactivation of ttcA results in hypersensitivity towards hydrogen peroxide and hypochlorite treatments [ 68 ]. TtcA catalyzes the thiolation of C32 on tRNA Arg1 (s 2 C32), a rare modification that restricts codon recognition and improves aminoacylation [ 69 ]. The [4Fe-4S] cluster of TtcA is critical for its function and highly susceptible to damage by ROS.…”
Section: Stress Factors Modulating Trna Modificationsmentioning
confidence: 99%
“…The largest variety and the highest density of nucleobase modifications occur in the ASL domain, which have been suggested to play important roles in maintaining the structural integrity of the anticodon region (Machnicka et al 2014;Schweizer et al 2017). More specifically, some modifications have been proposed to help preorder the structure of the ASL loop to facilitate tRNA accommodation in the ribosome and optimize codonanticodon interactions (Auffinger and Westhof 1999;Sundaram et al 2000;Stuart et al 2003;Agris 2008;Vendeix et al 2008;Denmon et al 2011;Vangaveti et al 2020). The conserved purine at position 37 undergoes a wide assortment of modifications that are phylogenetically distributed among the three domains of life (bacteria, archaea, and eukarya) (Machnicka et al 2014).…”
Section: Introductionmentioning
confidence: 99%