A stroma szerepe a tumorok kialakulásában és                     progressziójában

Baranyi, Marcell; Lippai, Mónika; Szatmári, Zsuzsanna

doi:10.1556/650.2015.30294

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…The awareness of the tumor microenvironment (TME) has been proposed more than one hundred years ago. In the meantime, cancer research has discovered many several noteworthy roles of TME components not only in cancer metastasis, but also in cancer metabolism and development (31)(32)(33). TME consists of a web of cancer cells, stromal cells, immune cells, CAFs, exosomes, and extracellular matrix.…”

Section: Tumor-microenvironment Componentsmentioning

confidence: 99%

Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?

Mirza

Bhadresha²,

Mughal³

et al. 2023

Front. Oncol.

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Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally, with nearly half of patients detected in the advanced stages. This is due to the fact that symptoms associated with CRC often do not appear until the cancer has reached an advanced stage. This suggests that CRC is a cancer with a slow progression, making it curable and preventive if detected in its early stage. Therefore, there is an urgent clinical need to improve CRC early detection and personalize therapy for patients with this cancer. Recently, liquid biopsy as a non-invasive or nominally invasive approach has attracted considerable interest for its real-time disease monitoring capability through repeated sample analysis. Several studies in CRC have revealed the potential for liquid biopsy application in a real clinical setting using circulating RNA/miRNA, circulating tumor cells (CTCs), exosomes, etc. However, Liquid biopsy still remains a challenge since there are currently no promising results with high specificity and specificity that might be employed as optimal circulatory biomarkers. Therefore, in this review, we conferred the plausible role of less explored liquid biopsy components like mitochondrial DNA (mtDNA), organoid model of CTCs, and circulating cancer-associated fibroblasts (cCAFs); which may allow researchers to develop improved strategies to unravel unfulfilled clinical requirements in CRC patients. Moreover, we have also discussed immunotherapy approaches to improve the prognosis of MSI (Microsatellite Instability) CRC patients using neoantigens and immune cells in the tumor microenvironment (TME) as a liquid biopsy approach in detail.

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Section: Tumor-microenvironment Componentsmentioning

confidence: 99%

Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?

Mirza

Bhadresha²,

Mughal³

et al. 2023

Front. Oncol.

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“…Further on, it becomes evident that this autonomy is not complete. All neoplasias ultimately depend on the host for their nutrition and vascular supply; many forms of neoplasias require endocrine support [7,8]. Some neoplastic cells are "immortal"; they die when the host dies, which indicates the intimate and intricate neoplasia/host relationship [9,10].…”

Section: Neoplasms In Teleost Fishmentioning

confidence: 99%

Neoplasias in Fish: Review of the Last 20 Years. A Look from the Pathology

Romano

Pedrosa

2020

ARRB

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In fish there is an innumerable variety of neoplasias that arise essentially from all cell types. Neolasia here, we will focus on the neoplasias that appear spontaneously in these animals and will not cover the experimentally induced neoplasias and/or the animal models of neoplasias. As for diagnosis, in general, specialists in aquatic organism pathology are not so familiar with the diagnosis of neoplasias. Infectious pathology, as opposed to non-infectious pathology, is the predominant condition in this area and, of course, these are of greater importance because some infectious diseases generate great economic losses, while neoplasias are isolated pathologies, with some exceptions. In the last 20 years, 10 neoplasias in different species have been diagnosed in our laboratory, and we reported their characteristics in this paper. We also made a detailed bibliography review and observed how 90 neoplasias among 56 species of teleosteal fish were reported. Neoplasias in fish, unlike other diseases, do not generate great losses to aquaculture. However, the true value of neoplastic pathology compared is to better understand the histiogenesis and biological behavior of neoplasias in mammals and humans. Carcinogenesis is generally complex and in most neoplasias in both mammals and fish, the origin is unknown, and it seems that there are many factors that contribute to the onset and growth of neoplasias.

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“…Другой потенциальной мишенью, связанной со стромой опухоли, является повышенный внеклеточный рН. Было показано, что бикарбонат натрия способен тормозить переход опухоли из статуса in situ в инвазивный рост [38].…”

Section: обзоры литературыunclassified

Therapies Targeting Cancer Stem Cells of the Tumor: The One and Only Hope

Vartanyan¹,

Барышников²

2016

Rossijskij bioterapevtičeskij žurnal

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The basic problem in cancer treatment remains the identification of cells responsible for maintaining the whole population of cells in a tumor. For decades it has been considered that all transformed cells within a tumor have carcinogenic potential with unlimited proliferation capacity and metastases formation. At present, the concept of cancer stem cell was introduced indicating that tumor evolves from a small population of long-live and slow proliferating cells. These cells have the capacity to initiate the tumor formation in immunodeficient animals. Among their properties, resistance to standard oncology treatments leads to treatment failure and cancer recurrence. The management and eradication of different types cancer is completely depended on removal of this cell population. Current review presents basic information about cancer stem cell, particularly, the initiation of tumor, the peculiar properties of cancer stem cell, the role of cancer stem cell in metastasis formation and discusses therapeutic strategies targeted cancer stem cell.

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A stroma szerepe a tumorok kialakulásában és progressziójában

Cited by 5 publications

References 48 publications

Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?

Liquid biopsy approaches and immunotherapy in colorectal cancer for precision medicine: Are we there yet?

Neoplasias in Fish: Review of the Last 20 Years. A Look from the Pathology

Therapies Targeting Cancer Stem Cells of the Tumor: The One and Only Hope

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