A Stratum corneum lipid model as a platform for biophysical profiling of bioactive chemical interactions at the skin level

Fernandes, Eduarda; López-Sicilia, Irene; Martín-Romero, Maria Teresa; Giner-Casares, Juan; Lúcio, Marlene

doi:10.1016/j.molliq.2024.124513

Cited by 1 publication

(1 citation statement)

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“…Vibrational changes in the lipid layer, specifically symmetric and asymmetric CH 2 stretching at approximately 2850 and 2920 cm −1 , respectively, are attributed to the structural disorganization of the SC layer [51,52]. The SC layer separated from YMP skin was treated with SP-4098 and SP-4287, FTIR measurements were conducted, and the results were compared with those for a non-treated SC sheet as a control.…”

Section: Effect Of Il-s/o Patches On the Sc Layermentioning

confidence: 99%

Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

Islam,

Nabila,

Wakabayashi

et al. 2024

Molecules

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Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O nanodispersion and a PSA were first mixed at an equal weight ratio, then coated onto a release liner, and covered with a support film. To evaluate the effect of the PSA, three types of PSAs, DURO-TAK 87-4098, DURO-TAK 87-4287, and DURO-TAK 87-235A, were used to obtain the corresponding IL-S/O patches SP-4098, SP-4287, and SP-235A, respectively. The prepared IL-S/O patches were characterized for surface morphology, viscoelasticity, and moisture content. In vitro skin penetration and in vivo immunization studies of the IL-S/O patches were performed using Yucatan micropig skin and the C57BL/6NJc1 mice model, respectively. The SP-4098 and SP-4287 delivered 5.49-fold and 5.47-fold higher amounts of drug compared with the aqueous formulation. Although both patches delivered a similar amount of drug, SP-4287 was not detached fully from the release liner after 30 days, indicating low stability. Mice immunized with the OVA-containing SP-4098 produced a 10-fold increase in anti-OVA IgG compared with those treated with an aqueous formulation. These findings suggested that the IL-S/O patch may be a good platform for the transdermal delivery of antigen molecules.

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Section: Effect Of Il-s/o Patches On the Sc Layermentioning

confidence: 99%