According to widely accepted sequence stratigraphic and fill-and-spill models, sedimentary cyclicity along continental margins is modulated by relative sea-level change, whereas smaller-scale intraslope accommodation is controlled by the filling of pre-existing bathymetric depressions. Although these concepts are presumed to apply to shelf-to-slope settings regardless of grain size, we have tested both hypotheses in the mud-prone lower Pliocene to Holocene of offshore Louisiana, Gulf of Mexico, and reach different conclusions. We determine that over the last ~3.7 Myr, differential accumulation and accompanying salt tectonism dislocated the fine-grained shelf and slope, prevented the development of sedimentary reciprocity at 10-100 kyr time scales,